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Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity

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Synaptic Plasticity and the Mechanism of Alzheimer's Disease

Part of the book series: Research and Perspectives in Alzheimer's Disease ((ALZHEIMER))

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Abstract

AMPA-type glutamate receptors are among the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses lead to long-lasting forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD). In addition, AMPA receptors (AMPARs) reach their synaptic targets after a complicated journey involvingmultiple transport steps through different membrane compartments. This chapter summarizes our current knowledge of the trafficking pathways of AMPARs and their relation to synaptic function and plasticity.

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Authors and Affiliations

  1. Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA

    José A. Esteban

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  1. José A. Esteban
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Editors and Affiliations

  1. Center for Neurologic Diseases, Brigham andWomen’s Ho, Harvard Medical School, 02115, Boston, MA, USA

    Dennis J. Selkoe

  2. Laboratoire de Biologie Cellulaire de la Synapse, Institut National de la Santé et de la Recherche, Médicale Unite 789, 46 rue d’Ulm, 75005, Paris, France

    Antoine Triller

  3. Pour la Recherche Thérapeutique, Fondation IPSEN, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Yves Christen

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Esteban, J. (2008). Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity. In: Selkoe, D., Triller, A., Christen, Y. (eds) Synaptic Plasticity and the Mechanism of Alzheimer's Disease. Research and Perspectives in Alzheimer's Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76330-7_2

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