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Cough Sensors. II. Transient Receptor Potential Membrane Receptors on Cough Sensors

  • Chapter
Pharmacology and Therapeutics of Cough

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 187))

Abstract

The transient receptor potential (TRP) family of channels is represented by at least six members in primary sensory neurons. These include the TRP vanilloid subtypes 1 (TRPV1), 2, 3, and 4, the cold and menthol receptor TRPM8, and TRPA1. Much interest has been directed to the study of the TRPV1, because capsaicin has been instrumental in discovering the unique role of a subset of primary sensory neurons in causing nociceptive responses, in activating reflex pathways including cough, and in producing neurogenic inflammation. TRPV1 is now regarded as an integrator of diverse sensory modalities because it undergoes marked plasticity and sensitization through a variety of mechanisms, including activation of G-protein-coupled or tyrosine kinase receptors. Evidence in experimental animals and in patients with airway diseases indicates a marked hypersensitivity to cough induced by TRPV1 agonists. Recent studies with newly developed high-affinity and selective TRPV1 antagonists have revealed that TRPV1 inhibition reduces cough induced by citric acid or antigen challenge.

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Authors and Affiliations

  1. Department of Critical Care Medicine and Surgery, University of Florence, Viale Pieraccini, 6, Florence, 50139, Italy

    S. Materazzi, R. Nassini, R. Gatti, M. Trevisani & P. Geppetti

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  1. S. Materazzi
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  2. R. Nassini
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  3. R. Gatti
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  4. M. Trevisani
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Editors and Affiliations

  1. National Heart & Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK

    Kian Fan Chung

  2. University of London, 116 Pepys Road, London, SW20 8NY, UK

    John Widdicombe

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Materazzi, S., Nassini, R., Gatti, R., Trevisani, M., Geppetti, P. (2009). Cough Sensors. II. Transient Receptor Potential Membrane Receptors on Cough Sensors. In: Chung, K.F., Widdicombe, J. (eds) Pharmacology and Therapeutics of Cough. Handbook of Experimental Pharmacology, vol 187. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79842-2_3

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