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Wirkungen und Stoffwechsel der wichtigsten natürlichen Sexualsteroide der Frau

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Klinische Endokrinologie für Frauenärzte

Zusammenfassung

Die sog. Sexualsteroide der Frau lassen sich den Hormongruppen der Östrogene, der Gestagene und der Androgene zuordnen. Sie werden im weiblichen Organismus gebildet und sind an der Regulation zahlreicher physiologischer Prozesse beteiligt. Bei der Frau unterliegen essenzielle biologische Prozesse wie die Embryonalentwicklung, die neuroendokrine Steuerung des weiblichen Zyklus, die Vorbereitung des Fortpflanzungstrakts für Fertilisation und Implantation sowie wichtige Vorgänge im Kohlenhydrat-, Eiweiß- und Fettstoffwechsel der Kontrolle durch Sexualsteroide. Auch das geschlechtsspezifische Verhalten wird durch die genannten Steroidhormone wesentlich mitgeprägt.

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Literatur

  • Aranda A, Pascual A (2001) Nuclear hormone receptors and gene expression. Physiol Rev 81: 1269

    PubMed  CAS  Google Scholar 

  • Arpino G, Wiechmann L, Osborne CK, Schiff R (2008) Cross-talk between estrogen receptor and HER tyrosine kinase receptor family: molecular mechanisms and clinical implications for endocrine therapy resistance. Endocr Rev 29: 217–233

    PubMed  CAS  Google Scholar 

  • Bentley P (1980) The adrenal glands. In: PJB (ed) Endocrine pharmacology. Cambridge University Press, Cambridge, p 149

    Google Scholar 

  • Bondy PK (1985) Disorders of the adrenal cortex. In: Wilson JD, Foster DW (ed) Williams textbook of endocrinology. Saunders, Philadelphia, p 816

    Google Scholar 

  • Briggs MH, Briggs M (1985) Pharmacology of hormonal contraceptives. In: Shearman RP (ed) Clinical reproductive endocrinology. Churchill Livingstone, Edinburgh, p 656

    Google Scholar 

  • Brzozowski AM, Pike AC, Dauter Z et al. (1997) Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389: 753

    PubMed  CAS  Google Scholar 

  • Campos H, Sacks FM, Walsh BW et al. (1993) Differential effects of estrogen on low-density lipoprotein subclasses in healthy postmenopausal women. Metabolism 42: 1153

    PubMed  CAS  Google Scholar 

  • Carani C, Qin K, Simoni M et al. (1997) Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 337: 91

    PubMed  CAS  Google Scholar 

  • Carson-Jurica MA, Schrader WT, O’Malley BW (1990) Steroid receptor family: structure and function. Endocr Rev 11: 201

    PubMed  CAS  Google Scholar 

  • Castoria G, Barone MV, Di Domenico M et al. (1999) Non-transcriptional action of oestradiol and progestin triggers DNA synthesis. EMBO J 18: 2500

    PubMed  CAS  Google Scholar 

  • Cato AC, Nestl A, Mink S (2002) Rapid actions of steroid receptors in cellular signaling pathways. Sci STKE 2002: RE9

    PubMed  Google Scholar 

  • Chwalisz K, Garg R, Brenner RM et al. (2002) Selective progesterone receptor modulators (SPRMs): a novel therapeutic concept in endometriosis. Ann NY Acad Sci 955: 373

    PubMed  CAS  Google Scholar 

  • Ciocca DR, Roig LM (1995) Estrogen receptors in human nontarget tissues: biological and clinical implications. Endocr Rev 16: 35

    PubMed  CAS  Google Scholar 

  • Clark BJ, Soo SC, Caron KM et al. (1995) Hormonal and developmental regulation of the steroidogenic acute regulatory protein. Mol Endocrinol 9: 1346

    PubMed  CAS  Google Scholar 

  • Clarke CL, Sutherland RL (1990) Progestin regulation of cellular proliferation. Endocr Rev 11: 266

    PubMed  CAS  Google Scholar 

  • Cleland WH, Mendelson CR, Simpson ER (1985) Effects of aging and obesity on aromatase activity of human adipose cells. J Clin Endocrinol Metab 60: 174

    PubMed  CAS  Google Scholar 

  • Conneely OM, Mulac-Jericevic B, DeMayo F et al. (2002) Reproductive functions of progesterone receptors. Recent Prog Horm Res 57: 339

    PubMed  CAS  Google Scholar 

  • Couse JF, Korach KS (1999) Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 20: 358

    PubMed  CAS  Google Scholar 

  • Daughaday WH (1985) The anterior pituitary. In: Wilson JD, Foster DW (eds) Williams textbook of endocrinology. Saunders, Philadelphia, p 568

    Google Scholar 

  • Delmas PD (2002) Treatment of postmenopausal osteoporosis. Lancet 359: 2018

    PubMed  CAS  Google Scholar 

  • Ebeling P, Koivisto VA (1994) Physiological importance of dehydroepiandrosterone. Lancet 343: 1479

    PubMed  CAS  Google Scholar 

  • Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240: 889

    PubMed  CAS  Google Scholar 

  • Fernandes MS, Brosens JJ, Gellersen B (2008) Honey, we need to talk about the membrane progestin receptors. Steroids 73: 942–952

    PubMed  CAS  Google Scholar 

  • Friedman CI, Kim MH (1985) Obesity and its effect on reproductive function. Clin Obstet Gynecol 28: 645

    PubMed  CAS  Google Scholar 

  • Gambacciani M, Ciaponi M, Cappagli B et al. (1997) Body weight, body fat distribution, and hormonal replacement therapy in early post-menopausal women. J Clin Endocrinol Metab 82: 414

    PubMed  CAS  Google Scholar 

  • Giguere V (1999) Orphan nuclear receptors: from gene to function. Endocr Rev 20: 689

    PubMed  CAS  Google Scholar 

  • Godsland IF (1996) The influence of female sex steroids on glucose metabolism and insulin action. J Intern Med 738 (Suppl): 1

    CAS  Google Scholar 

  • Godsland IF, Crook D, Simpson R et al. (1990) The effects of different formulations of oral contraceptive agents on lipid and carbohydrate metabolism. N Engl J Med 323: 1375

    PubMed  CAS  Google Scholar 

  • Godsland IF, Walton C, Felton C et al. (1992) Insulin resistance, secretion, and metabolism in users of oral contraceptives. J Clin Endocrinol Metab 74: 64

    PubMed  CAS  Google Scholar 

  • Grazzini E, Guillon G, Mouillac B, Zingg HH (1998) Inhibition of oxytocin receptor function by direct binding of progesterone. Nature 392: 509

    PubMed  CAS  Google Scholar 

  • Griekspoor A, Zwart W, Neefjes J, Michalides R (2007) Visualizing the action of steroid hormone receptors in living cells. Nucl Receptor Signal 5: 1

    Google Scholar 

  • Gruber CJ, Tschugguel W, Schneeberger C, Huber JC (2002) Production and actions of estrogens. N Engl J Med 346: 340

    PubMed  CAS  Google Scholar 

  • Hall JM, McDonnell DP (1999) The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 140: 5566

    PubMed  CAS  Google Scholar 

  • Hall JM, McDonnell DP (2005) Coregulators in nuclear estrogen receptor action. Mol Interventions 5: 343

    Google Scholar 

  • Hammes SR, Levin ER (2007) Extra-nuclear steroid receptors: nature and actions. Endocr Rev 28: 726

    PubMed  CAS  Google Scholar 

  • Hammond GL, Bocchinfuso WP (1996) Sex hormone-binding globulin: gene organization and structure/function analyses. Horm Res 45: 197

    PubMed  CAS  Google Scholar 

  • Haning RV Jr, Hackett RJ, Flood CA et al. (1993) Testosterone, a follicular regulator: key to anovulation. J Clin Endocrinol Metab 77: 710

    PubMed  CAS  Google Scholar 

  • Heinlein CA, Chang C (2002) Androgen receptor (AR) coregulators: an overview. Endocr Rev 23: 175

    PubMed  CAS  Google Scholar 

  • Hofbauer LC, Khosla S, Dunstan CR et al. (2000) The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 15: 2

    PubMed  CAS  Google Scholar 

  • Johnson MD, Bebb RA, Sirrs SM (2002) Uses of DHEA in aging and other disease states. Ageing Res Rev 1: 29

    PubMed  CAS  Google Scholar 

  • Jones ME, Boon WC, Proietto J, Simpson ER (2006) Of mice and men: the evolving phenotype of aromatase deficiency. Trends Endocrinol Metab 17: 55

    PubMed  Google Scholar 

  • Kirschner MA, Samojlik E, Drejka M et al. (1990) Androgen-estrogen metabolism in women with upper body versus lower body obesity. J Clin Endocrinol Metab 70: 473

    PubMed  CAS  Google Scholar 

  • Koh KK, Horne MK 3rd, Csako G et al. (1999) Relation of fibrinolytic potentiation by estrogen to coagulation pathway activation in post-menopausal women. Am J Cardiol 83: 466

    PubMed  CAS  Google Scholar 

  • Kol S, Adashi EY (1995) Intraovarian factors regulating ovarian function. Cur Opin Obstet Gynecol 7: 209

    CAS  Google Scholar 

  • Korach KS (2000) Estrogen receptor knock-out mice: molecular and endocrine phenotypes. J Soc Gynecol Investig 7: S16

    PubMed  CAS  Google Scholar 

  • Kousteni S, Bellido T, Plotkin LI et al. (2001) Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104: 719

    PubMed  CAS  Google Scholar 

  • Kuiper GG, Carlsson B, Grandien K et al. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138: 863

    PubMed  CAS  Google Scholar 

  • Kuiper GG, Enmark E, Pelto-Huikko M et al. (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93: 5925

    PubMed  CAS  Google Scholar 

  • La Spada AR, Wilson EM, Lubahn DB et al. (1991) Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 352: 77

    PubMed  Google Scholar 

  • Lejeune-Lenain C, van Cauter E, Desir D et al. (1987) Control of circadian and episodic variations of adrenal androgens secretion in man. J Endocrinol Invest 10: 267

    PubMed  CAS  Google Scholar 

  • Liehr JG (2000) Role of DNA adducts in hormonal carcinogenesis. Regul Toxicol Pharmacol 32: 276

    PubMed  CAS  Google Scholar 

  • Lin D, Sugawara T, Strauss JF 3rd et al. (1995) Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267: 1828

    PubMed  CAS  Google Scholar 

  • Lobo RA (1991) Clinical review 27: effects of hormonal replacement on lipids and lipoproteins in postmenopausal women. J Clin Endocrinol Metab 73: 925

    PubMed  CAS  Google Scholar 

  • Longcope C (1995) Metabolism of dehydroepiandrosterone. Ann NY Acad Sci 774: 143

    PubMed  CAS  Google Scholar 

  • MacDonald PC, Edman CD, Hemsell DL et al. (1978) Effect of obesity on conversion of plasma androstenedione to estrone in postmenopausal women with and without endometrial cancer. Am J Obstet Gynecol 130: 448

    PubMed  CAS  Google Scholar 

  • MacDonald PC, Siiteri PK (1974) The relationship between the extraglandular production of estrone and the occurrence of endometrial neoplasia. Gynecol Oncol 2: 259

    PubMed  CAS  Google Scholar 

  • McDonnell DP, Chang CY, Norris JD (2001) Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM. Ann NY Acad Sci 949: 16

    Article  PubMed  CAS  Google Scholar 

  • McDonnell DP, Norris JD (2002) Connections and regulation of the human estrogen receptor. Science 296: 1642

    PubMed  CAS  Google Scholar 

  • McEwen B (2002) Estrogen actions throughout the brain. Recent Prog Horm Res 57: 357

    PubMed  CAS  Google Scholar 

  • McEwen BS, Coirini H, Schumacher M (1990) Steroid effects on neuronal activity: when is the genome involved? Ciba Found Symp 153: 3

    PubMed  CAS  Google Scholar 

  • McPhaul MJ, Griffin JE (1999) Male pseudohermaphroditism caused by mutations of the human androgen receptor. J Clin Endocrinol Metab 84: 3435

    PubMed  CAS  Google Scholar 

  • Mellon SH, Griffin LD, Compagnone NA (2001) Biosynthesis and action of neurosteroids. Brain Res Brain Res Rev 37: 3

    PubMed  CAS  Google Scholar 

  • Mendel CM (1989) The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev 10: 232

    PubMed  CAS  Google Scholar 

  • Migliaccio A, Castoria G, Di Domenico M et al. (2000) Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation. Embo J 19: 5406

    PubMed  CAS  Google Scholar 

  • Miller WL (2007) Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter. Biochim Biophys Acta 1771: 663

    PubMed  CAS  Google Scholar 

  • Nair KS, Rizza RA, O’Brien P et al. (2006) DHEA in elderly women or testosterone in elderly men. N Engl J Med 355: 1647

    PubMed  CAS  Google Scholar 

  • Nakamura T, Imai Y, Matsumoto T et al. (2007) Estrogen prevents bone loss via estrogen receptor α and induction of Fas ligand in osteoclasts. Cell 130: 811

    PubMed  CAS  Google Scholar 

  • Negro-Vilar A (1999) Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium. J Clin Endocrinol Metab 84: 3459

    PubMed  CAS  Google Scholar 

  • Nimrod A, Ryan KJ (1975) Aromatization of androgens by human abdominal and breast fat tissue. J Clin Endocrinol Metab 40: 367

    PubMed  CAS  Google Scholar 

  • Nippoldt TB, Nair KS (1998) Is there a case for DHEA replacement? Baillieres Clin Endocrinol Metab 12: 507

    PubMed  CAS  Google Scholar 

  • Ottosson UB, Nilsson B, Sodergard R, von Schoultz B (1985) Effects of progesterone, progestogens, and danazol on the specific cortisol binding in human plasma. Fertil Steril 43: 856

    PubMed  CAS  Google Scholar 

  • Penning TM (1997) Molecular endocrinology of hydroxysteroid dehydrogenases. Endocr Rev 18: 281

    PubMed  CAS  Google Scholar 

  • Polderman KH, Stehouwer CD, van Kamp GJ et al. (1993) Influence of sex hormones on plasma endothelin levels. Ann Intern Med 118: 429

    PubMed  CAS  Google Scholar 

  • Prior JC (2006) FSH and bone — important physiology or not? Trends Mol Med 13: 1

    PubMed  Google Scholar 

  • Prossnitz ER, Arterburn JB, Smith HO, Oprea TI, Sklar LA, Hathaway HJ (2008) Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol 70: 165

    PubMed  CAS  Google Scholar 

  • Randall VA (1994) Role of 5α-reductase in health and disease. Baillieres Clin Endocrinol Metab 8: 405

    PubMed  CAS  Google Scholar 

  • Revelli A, Massobrio M, Tesarik J (1998) Nongenomic actions of steroid hormones in reproductive tissues. Endocr Rev 19: 3

    PubMed  CAS  Google Scholar 

  • Riggs BL, Melton LJ 3rd (1992) The prevention and treatment of osteoporosis. N Engl J Med 327: 620

    PubMed  CAS  Google Scholar 

  • Rosner W (1990) The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances. Endocr Rev 11: 80

    PubMed  CAS  Google Scholar 

  • Rosner W, Hryb DJ, Khan MS et al. (1999) Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane. J Steroid Biochem Mol Biol 69: 481

    PubMed  CAS  Google Scholar 

  • Ross GT (1985) Disorders of the ovary and female reproductive tract. In: Wilson JD, Foster DW (eds) Textbook of endocrinology, 7th edn. Saunders, Philadelphia, p 206

    Google Scholar 

  • Rupprecht R, DiMichele F, Hermann B et al. (2001) Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology. Brain Res Brain Res Rev 37: 59

    PubMed  CAS  Google Scholar 

  • Sack MN, Rader DJ, Cannon RO 3rd (1994) Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet 343: 269

    PubMed  CAS  Google Scholar 

  • Schaefer M, Hofmann T, Schultz G, Gudermann T (1998) A new prostaglandin E receptor mediates calcium influx and acrosome reaction in human spermatozoa. Proc Natl Acad Sci USA 95: 3008

    PubMed  CAS  Google Scholar 

  • Serafini P, Lobo RA (1985) Increased 5 alpha-reductase activity in idiopathic hirsutism. Fertil Steril 43: 74

    PubMed  CAS  Google Scholar 

  • Shumaker SA, Legault C, Kuller L et al. (2004) Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women’s Health Initiative Memory Study. JAMA 291: 2947

    PubMed  CAS  Google Scholar 

  • Simpson ER, Davis SR (2001) Aromatase and the regulation of estrogen biosynthesis — some new perspectives. Endocrinology 142: 4589

    PubMed  CAS  Google Scholar 

  • Simpson ER, Mahendroo MS, Means GD et al. (1994) Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev 15: 342

    PubMed  CAS  Google Scholar 

  • Smith DF, Toft DO (1993) Steroid receptors and their associated proteins. Mol Endocrinol 7: 4

    PubMed  CAS  Google Scholar 

  • Smith EP, Boyd J, Frank GR et al. (1994) Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331: 1056

    PubMed  CAS  Google Scholar 

  • Stocco DM, Clark BJ (1996) Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 17: 221

    PubMed  CAS  Google Scholar 

  • Sun L, Peng Y, Sharrow AC et al. (2006) FSH directly regulates bone mass. Cell 125: 247

    PubMed  CAS  Google Scholar 

  • Tilley WD, Buchanan G, Hickey TE, Bentel JM (1996) Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence. Clin Cancer Res 2: 277

    PubMed  CAS  Google Scholar 

  • The Writing Group for the PEPI Trial (1995) Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA 273: 199

    Google Scholar 

  • Tseng L, Liu HC (1981) Stimulation of arylsulfotransferase activity by progestins in human endometrium in vitro. J Clin Endocrinol Metab 53: 418

    PubMed  CAS  Google Scholar 

  • Turgeon JL, Carr MC, Maki PM, Mendelsohn ME, Wise PM (2006) Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studies. Endocr Rev 27: 575

    PubMed  CAS  Google Scholar 

  • Turgeon JL, McDonnell DP, Martin KA, Wise PM (2004) Hormone therapy: Physiological complexity belies therapeutic simplicity. Science 304: 1269

    PubMed  CAS  Google Scholar 

  • Valverde MA, Rojas P, Amigo J et al. (1999) Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. Science 285: 1929

    PubMed  CAS  Google Scholar 

  • Walsh BW, Schiff I, Rosner B et al. (1991) Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med 325: 1196

    PubMed  CAS  Google Scholar 

  • Webb R, Campbell BK (2007) Development of the dominant follicle: mechanisms of selection and maintenance of oocyte quality. Soc Reprod Fertil 64 (Suppl): 141

    CAS  Google Scholar 

  • Wijayaratne AL, Nagel SC, Paige LA et al. (1999) Comparative analyses of mechanistic differences among antiestrogens. Endocrinology 140: 5828

    PubMed  CAS  Google Scholar 

  • Wilson JD (1999) The role of androgens in male gender role behavior. Endocr Rev 20: 726

    PubMed  CAS  Google Scholar 

  • Yager JD, Davidson NE (2006) Mechanisms of disease: Estrogen carcinogenesis in breast cancer. N Engl J Med 354: 270

    PubMed  CAS  Google Scholar 

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Gudermann, T. (2009). Wirkungen und Stoffwechsel der wichtigsten natürlichen Sexualsteroide der Frau. In: Leidenberger, F., Strowitzki, T., Ortmann, O. (eds) Klinische Endokrinologie für Frauenärzte. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89760-6_2

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