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Genotype and Haplotype Reconstruction from Low-Coverage Short Sequencing Reads

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Bioinformatics and Computational Biology (BICoB 2009)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 5462))

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Abstract

Recent advances in high-throughput sequencing (HTS) technologies have led to orders of magnitude higher throughput compared to classic Sanger sequencing (see [3] for a review). Coupled with continuously decreasing sequencing costs, HTS data provides opportunities to study genome structure, function, and evolution at an unprecedented scale, and is profoundly transforming biomedical research.

Work supported in part by NSF awards IIS-0546457 and DBI-0543365.

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References

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Author information

Authors and Affiliations

  1. Department of Computer Science & Engineering, University of Connecticut, 371 Fairfield Rd., Unit 2155, Storrs, CT 06269-2155, USA

    Ion Măndoiu

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  1. Ion Măndoiu
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Editor information

Editors and Affiliations

  1. Department of Computer Science and Engineering, University of Connecticut, 257 ITE Building, 371 Fairfield Way, CT 06269-2155, Storrs, USA

    Sanguthevar Rajasekaran

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© 2009 Springer-Verlag Berlin Heidelberg

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Măndoiu, I. (2009). Genotype and Haplotype Reconstruction from Low-Coverage Short Sequencing Reads. In: Rajasekaran, S. (eds) Bioinformatics and Computational Biology. BICoB 2009. Lecture Notes in Computer Science(), vol 5462. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00727-9_7

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  • DOI: https://doi.org/10.1007/978-3-642-00727-9_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-00726-2

  • Online ISBN: 978-3-642-00727-9

  • eBook Packages: Computer ScienceComputer Science (R0)

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