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Large-Scale Analyses of Positive Selection Using Codon Models

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Evolutionary Biology

Abstract

Positive selection is the mechanism of adaptation to the environment, as well as the main source of novelty in evolution and thus it is of great interest to find its trace in genomes. During the last decade, different evolutionary models have been developed to detect positive selection at the gene level, based on divergence between species. Most recently, these models have been applied to large-scale comparisons of genomes. We present in this chapter some strengths and limitations of such genomic scans for positive selection and discuss the main recent large-scale studies, as well as relevant databases. We particularly discuss our recent results concerning the impact of genome duplication in vertebrate evolution and our related database Selectome.

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Author information

Authors and Affiliations

  1. Department of Ecology and Evolution, Biophore, Lausanne University, CH-1015, Lausanne, Switzerland

    Romain A. Studer & Marc Robinson-Rechavi

  2. Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland

    Romain A. Studer & Marc Robinson-Rechavi

Authors
  1. Romain A. Studer
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  2. Marc Robinson-Rechavi
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Correspondence to Marc Robinson-Rechavi .

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Editors and Affiliations

  1. CNRS UMR 6632, Université d'Aix-Marseille, place Victor Hugo 3, Marseille CX 03, 13331, France

    Pierre Pontarotti

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© 2009 Springer-Verlag Berlin Heidelberg

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Studer, R.A., Robinson-Rechavi, M. (2009). Large-Scale Analyses of Positive Selection Using Codon Models. In: Pontarotti, P. (eds) Evolutionary Biology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00952-5_13

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