Abstract
Computational models of myocardial perfusion in normal as well as pathological conditions have contributed to recent advances in the personalized diagnosis and treatment of cardiovascular disease.. For the coronary circulation we attempt to develop a vascular tree model based on realistic replicas from the intramural vessels in hearts from animals and man. These virtual replicas are obtained by means of a novel imaging cryomicrotome producing a stack of 4000 images of 2000x2000 pixels. This paper describes the methods developed for segmentation of the images resulting in a 3D virtual vascular model. Also the methods for fluorescent microsphere detection are described used to validate the models in prediction of flow distribution over the walls of the heart chambers. Special attention is provided to the detection of collaterals and collateral flow.
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References
Molin, D., Post, M.J.: Therapeutic angiogenesis in the heart: protect and serve. Curr. Opin. Pharmacol. 7, 158–163 (2007)
Kern, M.J., Lerman, A., Bech, J.W., De Bruyne, B., Eeckhout, E., Fearon, W.F., Higano, S.T., Lim, M.J., Meuwissen, M., Piek, J.J., Pijls, N.H., Siebes, M., Spaan, J.A.E.: Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology. Circulation 114, 1321–1341 (2006)
Siebes, M., Verhoeff, B., Meuwissen, M., de Winter, R.J., Spaan, J.A.E., Piek, J.J.: Single-wire pressure and flow velocity measurement to quantify coronary stenosis hemodynamics and effects of percutaneous interventions. Circulation 109(6), 756–762 (2004)
Verhoeff, B.J., Siebes, M., Meuwissen, M., Atasever, B., Voskuil, M., de Winter, R.J., Koch, K.T., Tijssen, J.G., Spaan, J.A., Piek, J.J.: Influence of percutaneous coronary intervention on coronary microvascular resistance index. Circulation 111, 76–82 (2005)
Spaan, J.A.E., Piek, J.J., Hoffman, J.I.E., Siebes, M.: Physiological basis of clinically used coronary hemodynamic indices. Circulation 113(3), 446–455 (2006)
Spaan, J.A.E., ter Wee, R., van Teeffelen, J.W.G.E., Streekstra, G., Siebes, M., Kolyva, C., Vink, H., Fokkema, D.S., VanBavel, E.: Visualisation of intramural coronary vasculature by an imaging cryomicrotome suggests compartmentalisation of myocardial perfusion areas. Med. Biol. Eng. Comput. 43, 4 (2005)
Kelly, J.J., Ewen, J.R., Bernard, S.L., Glenny, R.W., Barlow, C.H.: Regional blood flow measurements from fluorescent microsphere images using an Imaging Cryomicrotome. Rev. Sci. Int. 71, 1 (2000)
Rolf, M.P., ter Wee, R., van Leeuwen, T.G., Spaan, J.A.E., Streekstra, G.J.: Diameter measurements from images of fluorescent cylinders embedded in tissue. Med. Biol. Eng. Comput. 46, 589–596 (2008)
Dougherty, R.P.: Extensions of DAMAS and benefits and limitations of deconvolution in beamforming, AIAA Paper 2005-2961 (2005)
Palágyia, K., Tschirren, J., Hoffman, E.A., Sonka, M.: Quantitative analysis of pulmonary airway tree structures. Computers in Biology and Medicine 36, 974–996 (2006)
Lee, J., Beighley, P., Ritman, E., Smith, N.: Automatic segmentation of 3D micro-CT coronary vascular images. Medical Image Analysis 11, 630–647 (2007)
Palágyi, A., Kuba, A.: 3D 6-subiteration thinning algorithm for extracting medial lines. Pattern Recognition Letters 19, 613–627 (1998)
Buckberg, G.D., Fixler, D.E., Archie, J.P., Hoffman, J.I.: Experimental Subendocardial Ischemia in Dogs with Normal Coronary Arteries. Circ. Res. 30, 67–81 (1972)
Lindeberg, T.: Feature detection with automatic scale selection. Int. J. of Computer Vision 30, 2 (1998)
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van Horssen, P. et al. (2009). Extraction of Coronary Vascular Tree and Myocardial Perfusion Data from Stacks of Cryomicrotome Images. In: Ayache, N., Delingette, H., Sermesant, M. (eds) Functional Imaging and Modeling of the Heart. FIMH 2009. Lecture Notes in Computer Science, vol 5528. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01932-6_52
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DOI: https://doi.org/10.1007/978-3-642-01932-6_52
Publisher Name: Springer, Berlin, Heidelberg
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