Abstract
The software treatment planning for particles (TRiP) was extended by the functionality to calculate the clinically relevant RBE-weighted dose for scanned ion beams in the presence of motion. Calculations are based on 4D-CT and deformable registration. The underlying biological model is the local effect model. To validate the dose calculation algorithm experimentally a dedicated motion phantom for biological dosimetry was developed. In-vitro cell survival measurements were performed with a target dose of 9 Gy (RBE). The mean dose difference between the calculation and the measurement and its standard deviation was obtained to be 155±400 mGy (RBE). This validates the calculation within the measurement error of 519 mGy (RBE).
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© 2009 Springer-Verlag Berlin Heidelberg
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Gemmel, A. et al. (2009). 4D calculation and biological dosimetry of the RBE-weighted dose for scanned carbon ion beam therapy. In: Dössel, O., Schlegel, W.C. (eds) World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. IFMBE Proceedings, vol 25/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03474-9_106
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DOI: https://doi.org/10.1007/978-3-642-03474-9_106
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-03472-5
Online ISBN: 978-3-642-03474-9
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