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Studies on α-Aminophosphonates with Antiviral Activity

  • Chapter
Environment-Friendly Antiviral Agents for Plants

Abstract Introduction

As a kind of natural amino acid analogue, α-aminophosphonates constitute an important class of compounds with diverse biological activities and potential to be employed as enzyme inhibitors, antibiotics, and anticancer agents. They also have a wide range of antiviral and antifungal properties and are extensively used as insecticides and herbicides.1–6 The importance of chiral α-aminophosphonates emanates from their increased industrial applications and evident from overwhelming rise in the number of reports on enantioenriched α-aminophosphonic acid derivatives.7–9 Some racemic a-aminiophosphonates containing fluorine or heterocycle moieties such as thiophene, pyrrole, 1,3,4-thiadiazole and benzothiazole are reported to have potential anticancer properties, with the later one displaying excellent fungicidal activity in addition to antitumour activity.10–13 However, further studies are necessary to identify chiral α-aminiophosphonates containing fluorine or heterocycle moieties with potent antitumour activities. Although, diasteroselective addition of phosphite derivatives to chiral imines, enantioselective addition of phosphites to imines in the presence of chiral metal complexes and other methods have been reported for the preparation of optically active α-aminiophosphonates,14–25 the need to develop a general practical asymmetric route for their synthesis from achiral acyclic imine and simple dialkyl phosphites still remains.

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  1. Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China

    Baoan Song, Linhong Jin, Song Yang & Pinaki S. Bhadury

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Song, B., Jin, L., Yang, S., Bhadury, P.S. (2010). Studies on α-Aminophosphonates with Antiviral Activity. In: Environment-Friendly Antiviral Agents for Plants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03692-7_2

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