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Genetics and Molecular Biology of Mesothelioma

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Malignant Mesothelioma

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 189))

Abstract

Mesothelioma remains an incurable cancer due to the ineffectiveness of conventional cytotoxic chemotherapy. This is reflected in the preponderance of mostly negative phase II clinical trials over the last 30 years [32]. Resistance to apoptosis is a hallmark of cancer in general [48], accounts for multidrug resistance [58], and is a signature of mesothelioma [31]. During tumorigenesis, it is now understood that as in common with other solid cancers, somatic genetic alteration is a frequent event predisposing to apoptosis resistance. These changes include the activation of oncogenic cell survival pathways, and the inactivation of tumor suppressors.

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    Dean A. Fennell

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Fennell, D.A. (2011). Genetics and Molecular Biology of Mesothelioma. In: Tannapfel, A. (eds) Malignant Mesothelioma. Recent Results in Cancer Research, vol 189. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-10862-4_9

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