Abstract
The image data from 348 breast CT studies performed on patient volunteers in a Phase II clinical trial were used in a pre-whitened matched filter (PWMF) model observer study. This computer-based investigation simulated the addition of spherical lesions of various diameters to the breast data sets, and a series of images with different slice thicknesses ranging from 0.3 mm to 44 mm were created by voxel averaging. The PWMF was tailored to each slice thickness, and signal known exactly receiver operating characteristic analysis was performed. A total of 1000 lesions and “non-lesions” were simulated for each diameter on each breast data set. Receiver operating characteristic (ROC) curve analysis was performed, and sensitivity at 95% specificity was computed. Thin slice imaging as with breast CT demonstrated significantly better sensitivity than thick slice images as with mammography, with improvements in sensitivity ranging from 5% to 50%.
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References
Boone, J.M., Nelson, T.R., Lindfors, K.K., Seibert, J.A.: Dedicated breast CT: Radiation dose and image quality evaluation. Radiology 221, 657–667 (2001)
Boone, J.M., Shah, N., Nelson, T.R.: A comprehensive analysis of DgNCT coefficients for pendant-geometry cone-beam breast computed tomography. Medical Physics 31, 226–235 (2004)
Kwan, A.L.C., Boone, J.M., Shah, N.: Evaluation of x-ray scatter properties in a dedicated cone-beam breast CT scanner. Med. Phys. 32, 2967–2975 (2005)
Boone, J.M., Kwan, A.L.C., Seibert, J.A., Shah, N., Lindfors, K.K.: Technique factors and their relationship to radiation dose in pendant geometry breast CT. Med. Phys. 32, 3767–3776 (2005)
Yang, K., Kwan, A.L.C., Miller, D.F., Boone, J.M.: A general geometric calibration method for cone beam CT systems. Med. Phys. 33, 1695–1706 (2006)
Boone, J.M., Lindfors, K.K.: Breast CT: potential for breast cancer screening and diagnosis. Future Oncol. 2, 351–356 (2006)
Boone, J.M., Kwan, A.L., Yang, K., Burkett, G.W., Lindfors, K.K., Nelson, T.R.: Computed tomography for imaging the breast. J. Mamary Gland Biol. Neoplasia 11, 103–111 (2006)
Yang, K., Kwan, A.L.C., Boone, J.M.: Computer modeling of the spatial resolution properties of a dedicated breast CT scanner. Med. Phys. 34(6), 2059–2069 (2006)
Kwan, A.L.C., Boone, J.M., Yang, K., Huang, S.Y.: Evaluation of the spatial resolution characteristics of a cone-beam breast CT scanner. Med. Phys. 34(1), 275–281 (2007)
Lindfors, K.K., Boone, J.M., Nelson, T.R., Yang, K., Kwan, A.L.C., Miller, D.W.: Dedication breast CT: Initial clinical experience. Radiology 246, 725–733 (2008)
Nelson, T.R., Cervino, L.I., Boone, J.M., Lindfors, K.K.: Classification of breast computed tomography data. Med. Phys. 35, 1078–1086 (2008)
Huang, S.-Y., Boone, J.M., Yang, K., Kwan, A.L.C., Packard, N.: Evaluation of breast skin thickness from 46 dedicated breast CT examinations. Med. Phys. 35, 1199–1206 (2008)
Xia, J.Q., Lo, J.Y., Yang, K., Floyd Jr., C.E., Boone, J.M.: Dedicated breast computed tomography: volume image denoising via a partial-diffusion equation based technique. Med. Phys. 35, 1950–1958 (2008)
Metheany, K.G., Abbey, C.K., Packard, N., Boone, J.M.: Characterizing anatomical variability in breast CT images. Med. Phys. 35, 4685–4694 (2008)
Yang, K., Kwan, A.L.C., Huang, S.-Y., Packard, N.J., Boone, J.M.: Noise power properties of a cone-beam CT system for breast cancer detection. Med. Phys. 35, 5317–5327 (2008)
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Boone, J.M., Packard, N.J., Abbey, C.K. (2010). Ideal Observer Comparison between Tomographic and Projection x-Ray Images of the Breast. In: Martí, J., Oliver, A., Freixenet, J., Martí, R. (eds) Digital Mammography. IWDM 2010. Lecture Notes in Computer Science, vol 6136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13666-5_80
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DOI: https://doi.org/10.1007/978-3-642-13666-5_80
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