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Monitoring of Wilms’ Tumor Gene Transcription in Leukemia Patients

  • Conference paper
Acute Leukemias VIII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 40))

  • 104 Accesses

Abstract

We examined the presence of WT1-specific mRNA in bone marrow aspirates or peripheral blood samples of 76 children suffered from acute leukemia at diagnosis and / or relapse. Samples were analyzed by RT-PCR. WT1 -specific mRNA was detected in 79% of patients at diagnosis and in 90% of samples at time of relapse.

The WT1 expression in bone marrow was monitored during the clinical course of some patients. The prognostic value and qualification of WT1 expression for monitoring of MRD (minimal residual disease) during chemotherapy must be confirmed. In contrast to other tumor-specific markers the applicability of WT1 gene expression in most cases of acute leukemia is an important advantage.

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Author information

Authors and Affiliations

  1. Department of Hematology and Oncology, J. W. Goethe-University, Frankfurt/Main, Germany

    E. Niegemann, S. Wehner, D. Schwabe & U. Ebener

Authors
  1. E. Niegemann
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  2. S. Wehner
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  3. D. Schwabe
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  4. U. Ebener
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine A, Germany

    T. Büchner

  2. Department of Internal Medicine III, University Hospital Großhadern Ludwig-Maximilians-University, Marchioninistr. 15, 81377, München, Germany

    W. Hiddemann

  3. Dept. of Internal Medicine, University of Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany

    B. Wörmann

  4. Department of Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, 48149, Münster, Germany

    G. Schellong , J. Ritter  & U. Creutzig ,  & 

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© 2001 Springer-Verlag Berlin Heidelberg

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Niegemann, E., Wehner, S., Schwabe, D., Ebener, U. (2001). Monitoring of Wilms’ Tumor Gene Transcription in Leukemia Patients. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J., Creutzig, U. (eds) Acute Leukemias VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18156-6_17

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  • DOI: https://doi.org/10.1007/978-3-642-18156-6_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62109-3

  • Online ISBN: 978-3-642-18156-6

  • eBook Packages: Springer Book Archive

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