Abstract
The period of remission maintenance therapy is an important, but less investigated part in the treatment of common acute lymphoblastic leukaemia (ALL) in children. In this part of treatment in the ALL-BFM-Trial the patient has to take daily 6-Mercaptopurine (6-MP) and weekly Methotrexate (MTX) orally. The aspect to be examined is the influence of non-compliance on the patient outcome. Case reports and experiences in other chronic diseases in children let us presume that there is an unknown high part of non-compliers. Therefore, we have developed a new non-invasive method to quantify MTX and 6-MP in urine with capillary electrophoresis (CE) as an additional assessing method to investigate the degree of non-compliance. The analytical method has been validated and first patient measurements revealed a case of possible non-compliance.
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© 2001 Springer-Verlag Berlin Heidelberg
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Wessel, T., Hempel, G., Boos, J. (2001). Drug Monitoring During Maintenance Therapy In Children with ALL. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J., Creutzig, U. (eds) Acute Leukemias VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18156-6_40
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DOI: https://doi.org/10.1007/978-3-642-18156-6_40
Publisher Name: Springer, Berlin, Heidelberg
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