Skip to main content
SpringerLink
Log in

Long-Term Outcome and Prognostic Factors in Children’s Cancer Group Study 2891 for Children and Adolescents with Previously Untreated Acute Myeloid Leukemia and Myelodysplastic Syndrome

  • Conference paper
Acute Leukemias VIII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 40))

  • 106 Accesses

Abstract

The primary objective of Children’s Cancer Group (CCG) study 2891 is to improve the event-free survival (EFS), disease-free survival (DFS) and survival of children with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The secondary objective to identify prognostically discrete subsets of patients. To achieve these objectives CCG-2891 uses randomized comparisons of 2 induction strategies and 3 post-remission strategies and prospectively examines several patient subsets.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Karp, J. E., Donehower, R. C, Enterline, J. P., Dole, G. B., Fox, M.G., and Burke, P. J. In vivo cell growth and pharmacologic determinants of clinical response in acute myelogenous leukemia, Blood. 73(1): 24–30, 1989.

    PubMed  CAS  Google Scholar 

  2. Vaughan, W. P., Karp, J. E., and Burke, P. J. Twocycle timed-sequential chemotherapy for adult acute nonlymphocytic leukemia, Blood. 64(5): 975–80, 1984.

    PubMed  CAS  Google Scholar 

  3. Burke, P. J., Karp, J. E., Geller, R. B., and Vaughan, W. P. Cures of leukemia with aggressive postremission treatment: an update of timed sequential therapy (Ac-D-Ac), Leukemia. 3(10):692–4, 1989.

    PubMed  CAS  Google Scholar 

  4. Woods, W. G., Ruymann, F. B., Lampkin, B. C., Buckley, J. D., Bernstein, I. D., Srivastava, A. K., Smithson, W. A., Benjamin, D. R., Feig, S. A., Kim, T. H., and al., e. The role of timing of high-dose cytosine arabinoside intensification and of maintenance therapy in the treatment of children with acute nonlymphocytic leukemia, Cancer. 66(6): 1106–13, 1990.

    Article  PubMed  CAS  Google Scholar 

  5. Nesbit, M. E., Jr., Buckley, J. D., Feig, S. A., Anderson, J. R., Lampkin, B., Bernstein, I. D., Kim, T. H., Piomelli, S., Kersey, J. H., Coccia, P. F., and al., e. Chemotherapy for induction of remission of childhood acute myeloid leukemia followed by marrow transplantation of multiagent chemotherapy: a report from the Children’s Cancer Group, Journal of Clinical Oncology. 12(1):127–35, 1994.

    PubMed  Google Scholar 

  6. Amadori, S., Testi, A. M., Arico, M., Comelli, A., Giuliano, M., Madon, E., Masera, G., Rondelli, R., Zanesco, L., and Mandelli, F. Prospective comparative study of bone marrow transplantation and postremission chemotherapy for childhood acute myelogenous leukemia. The Associazione Italiano Ematologia ed Oncologia Pediatrica Cooperative Group, Journal of Clinical Oncology. 11(6):1046–54, 1993.

    PubMed  CAS  Google Scholar 

  7. Dahl, G. V., Kalwinsky, D. K., Mirro, J., Jr, Look, A.T., Pui, C. H., Murphy, S. B., Mason, C, Ruggiero, M., Schell, M., Johnson, F. L., and al., e. Allogeneic bone marrow transplantation in a program of intensive sequential chemotherapy for children and young adults with acute rionlymphocytic leukemia in first remission, Journal of Clinical Oncology. 8(2):295–303, 1990.

    PubMed  CAS  Google Scholar 

  8. Wells, R. J., Woods, W. G., Buckley, J. D., Odom, L. E, Benjamin, D., Bernstein, I., Betcher, D., Feig, S., Kim, T., Ruymann, F., and al., e. Treatment of newly diagnosed children and adolescents with acute myeloid leukemia: a Children’s Cancer Group study, Journal of Clinical Oncology. 12(11):2367–77, 1994.

    PubMed  CAS  Google Scholar 

  9. Yeager, A. M., Kaizer, H., Santos, G. W, Sarai, R., Colvin, O. M., Stuart, R. K., Braine, H. G., Burke, P. J., Ambinder, R. E, Burns, W. H., and al., e. Autologous bone marrow transplantation in patients with acute nonlymphocytic leukemia, using ex vivo marrow treatment with 4-hydroperoxycyclophosphamide, New England Journal of Medicine. 315(3):141–7, 1986.

    Article  PubMed  CAS  Google Scholar 

  10. Dinndorf, P. and Bunin, N. Bone Marrow transplantation for children with acute myelogenous leukemia, Journal of Pediatric Hematology/Oncology. 17(3): 211–24, 1995.

    Article  PubMed  CAS  Google Scholar 

  11. Woods, W G., Kobrinsky, N., Buckley, J., Neudorf, S., Sanders, J., Miller, L., Barnard, D., Benjamin, D., DeSwarte, J., Kalousek, D., and al, e. Intensively timed induction therapy followed by autologous or allogeneic bone marrow transplantation for children with acute meyloid leukemia or myelo-dysplastic syndrome: a Children’s Cancer Group pilot study, Journal of Clinical Oncology. 11(8): 1448–57, 1993.

    PubMed  CAS  Google Scholar 

  12. Ravindranath, Y., Yeager, A. M., Chang, M. N., Steuber, C P., Krischer, J., Graham-Pole, J., Carroll, A., Inoue, S., Camitta, B., and Weinstein, H. J. Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. Pediatric Oncology Group, New England Journal of Medicine. 334(22):1428–34, 1996.

    Article  PubMed  CAS  Google Scholar 

  13. Michel, G., Baruchel, A., Tabone, M. D., Nelken, B., Leblanc, T., Thuret, L, Bordigoni, P., Bergeron, C, Esperou-Bourdeau, H., Perel, Y., Vannier, J. P., DeLumley, L., Dommergues, J. P., Lamagnere, J. P., Couillaud, G., Auvrignon, A., Schaison, G., and Leverger, G. Induction chemotherapy followed by allogeneic bone marrow transplantation or aggressive consolidation chemotherapy in childhood acute myeloblastic leukemia. A prospective study from the French Society of Pediatric Hematology and Immunology (SHIP), Hematology & Cell Therapy. 38(2):169–76, 1996.

    Article  CAS  Google Scholar 

  14. Vignetti, M., Rondelli, R., Locatelli, F., Lanino, E., Miniero, R., Rossetti, E, and Meloni, G. Autologous bone marrow transplantation in children with acute myeloblastic leukemia: report from the Italian National Pediatric Registry (AIEOP-BMT), Bone Marrow Transplantation. 18 Suppl 2:59–62, 1996.

    PubMed  CAS  Google Scholar 

  15. Ritter, J., Creutzig, U., and Schellong, G. Treatment results of three consecutive German childhood AML trials: BFM-78,-83, and-87. AML-BFM-Group, Leukemia. 6 Suppl 2:59–62, 1992.

    PubMed  Google Scholar 

  16. Stevens, R. F., Hann, I. M., Wheatley, K., and Gray, R. G. Marked improvements in outcome with chemotherapy alone in pediatric acute myeloid leukemia: results of the United Kingdom Medical Research Council’s 10th AML trial. MRC Childhood Leukaemia Working Party, British Journal of Haematology. 101(1):, 1998.

    Google Scholar 

  17. Woods, W. G., Kobrinsky, N., Buckley, J. D., Lee, J. W., Sanders, J., Neudorf, S., Gold, S., Barnard, D. R., DeSwarte, J., Dusenbery, K., Kalousek, D., Arthur, D. C., and Lange, B. J. Timed-sequential induction therapy improved postremission outcome in acute myeloid leukemia: a report from the Children’s Cancer Group, Blood. 82(12):4979–89, 1996.

    Google Scholar 

  18. Castro-Malaspina, H., Schaison, G., Passe, S., Pasquier, A., Berger, R., Bayle-Weisgerber, C, Miller, D., Seligmann, M., and Bernard, J. Subacute and chronic myelomonocytic leukemia in children (juvenile CML), Cancer. 54:675, 1984.

    Article  PubMed  CAS  Google Scholar 

  19. Wagelius, R. Bone marrow dysfunctions preceding acute leukemia in children: a clinical study, Leuk Res. 16:71, 1992.

    Article  Google Scholar 

  20. Passmore, S., Hann, C, Stiller, P., Ramani, G., Swansbury, B., Gibbons, B., Reeves, B., and Chessells, J. Pediatric myelodysplasia: a study of 68 children and a new prognostic scoring system, Blood. 85:1742, 1995.

    PubMed  CAS  Google Scholar 

  21. Luna-Fineman, S., Shannon, K. M., Atwater, S. K., Davis, J., Masterson, M., Ortega, J., Sanders, J., Steinherz, P., Weinberg, V., and Lange, B. J. Myelodysplastic and Myeloproliferative Disorders of Childhood: A Study of 167 Patients, BLood. 93(2): 459–466, 1999.

    PubMed  CAS  Google Scholar 

  22. Ravindranath, Y., Abella, E., Krischer, J. P., Wiley, J., Inoue, S., Harris, M., Chauvenet, A., Alvarado, C. S., Dubowy, R., Ritchey, A. K., and al, e. Acute myeloid leukemia (AML) in Down’s syndrome in highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498, Blood. 80(9):2210–4, 1992.

    PubMed  CAS  Google Scholar 

  23. Creutzig, U., Ritter, J., Vormoor, J., Ludwig, W. D., Niemeyer, C, Reinisch, I., Stollmann-Gibbels, B., Zimmermann, M., and Harbott., J. Myelodysplasia and acute myelogenous leukemia in Down’s syndrome. A report of 40 children on the AML-BFM Study Group, Leukemia. 10(11):1677–86, 1996.

    PubMed  CAS  Google Scholar 

  24. Lie, S. O., Jonmundsson, G., Mellander, L., Simes, M. A., Yssing, M., and Gustafsson, G. A populationbased study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down’s syndrome. Nordic Society of Paediatric Haematology and Oncology (NOPHO), British Journal of Haematology. 94(1):82–8, 1996.

    Article  PubMed  CAS  Google Scholar 

  25. Lange, B. J., Kobrinsky, N., Barnard, D. R., Arthur, D. C, Buckley, J. D., Howells, W B., Gold, S., Sanders, J., Neudorf, S., Smith, F. O., and Woods, W. G. Distinctive demography, biology and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: Children’s Cancer Group Studies 2861 and 2891, Blood. 91(2):608–15, 1998.

    PubMed  CAS  Google Scholar 

  26. LeBeau, M., Applebaum, F. R., and Willman, C. L. Secondary leukemia, Hematology 33–47, 1996.

    Google Scholar 

  27. Rubin, C. M., Arthur, D. C, Woods, W. G., Lange, B. J., Howell, P. C, Rowley, J. D., Nachman, J., Bostrom, B., Baum, E. S., Suarez, C. R., and al., e. Therapyrelated myelodysplastic syndrome and acute myeloid leukemia in children: correlation between chromosomal abnormalities and prior therapy, Blood. 78(11):2982–8, 1991.

    PubMed  CAS  Google Scholar 

  28. Barnard, D. R., Kalousek, D. K., Wiersma, S. R., Lange, B. J., Benjamin, D. R., Arthur, D. C, Buckley, J. D., Kobrinsky, N., Neudorf, S., Sanders, J., Miller, L. P., Shina, D. C, Hammond, G.D., and Woods, W. B. Morphologic, Immunologic and cytogenetic classification of actue myeloid leukemia and myelodysplastic syndrome in childhood: a report from the Children’s Cancer Group, Leukemia. 10(1):5–12, 1996.

    PubMed  CAS  Google Scholar 

  29. Capizzi, R. L., Davis, R., Powell, B., Cuttner, J., Ellison, R. R., Cooper, M. R., Dillman, R., Major, W. B., Dupre, E., and Mclntyre, O. R. Synergy between high-dose cytarabine and asparginase in the treatment of adults with refractory and relapsed acute myelogenous leukemia-a Cancer and Leukemia Group B study, Journal of Clinical Oncology. 6(3): 499–508, 1988.

    PubMed  CAS  Google Scholar 

  30. Dusenbery, K. E., Arthur, D. C, Howells, W, Lange, B. J., Lampkin, B., Buckley, J., Masterson, M., Lee, J. W, Nesbit, M. E., Wells, R. J., and Woods, W. G. Granulocytic sarcomas (chloromas) in pediatric patients with newly diagnosed acute myeloid leukemia (meeting abstract), Pro Annu Meet Am Soc Clin Oncol. 15:A1096, 1996.

    Google Scholar 

  31. Tallman, M. S., Andersen, J. W, Schiffer, C. A., Appelbaum, F. R., Feusner, J. H., Ogden, A., Shepherd, L., Willman, C., Bloomfield, C D., Rowe, J. M., and Wiernik, P. H. All-trans-retinoic acid in acute promyelocytic leukemia, New England Journal of Medicine. 337(15):1021–8, 1997.

    Article  PubMed  CAS  Google Scholar 

  32. Peto, R. and Peto, J. Asymptotically efficient rank in variant test procedures, J R STat Soc. (A)135: 185, 1972.

    Google Scholar 

  33. Kaplan, E. L. and Meier, P. Nonparametric estimation from incomplete observations, J AM Stat Assoc. 53:457, 1958.

    Article  Google Scholar 

  34. Greenwood, M. The natural duration of cancer. Reports on Public Health and Medical Subjects, 33, London UK, Her Majesty’s Stationery Office 1, 1926.

    Google Scholar 

  35. Yates, F. Contingency tables involving small numbers and the chi-square test, J of the Royal Statistical Soc. Supp 1:217, 1934.

    Google Scholar 

  36. Schiffer, C. A. Hematopoietic growth factors as adjuncts to the treatment of acute myeloid leukemia, Blood. 88(10):3675–85, 1996.

    PubMed  CAS  Google Scholar 

  37. Estey, E. Hematopoietic growth factors in the treatment of actue leukemia, Current Opinion in Oncology. 10(1):23–30, 1998.

    Article  PubMed  CAS  Google Scholar 

  38. Creutzig, U., Ritter, J., and Schellong, G. Identification of two risk groups in childhood acute myelogenous leukemia after therapy intensification in study AML-BFM-83 as compared with study AML-BFM-78. AML-BFM Study Group, Blood. 75(10): 1932–40, 1990.

    PubMed  CAS  Google Scholar 

  39. Hann, I. M., Stevens, R. F., Goldstone, A. H., Rees, J. K., Wheatley, K., Gray, R. G., and Burnett, A. K. Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia. Results of the Medical Research Council’s 10th AML trial (MRC AML 10). Adult and Childhood Leukaemia Working Parties of the Medical Research Council, Blood. 89(7):2311–8, 1997.

    PubMed  CAS  Google Scholar 

  40. Grier, H. E., Gelber, R. D., Camitta, B. M., Delorey, M. N., Link, M. P., Price, K. N., Leavitt, P. R., and Weinstein, H. J. Prognostic factors in childhood acute myelogenous leukemia, Journal of Clinical Oncology. 5(7):1026–32, 1987.

    PubMed  CAS  Google Scholar 

  41. Hurwitz, C. A., Schell, M. J., Pui, C. H., Crist, W. M., Behm, F., and Mirro, J., Jr. Adverse prognostic features in 251 children treated for acute myeloid leukemia, Medical & Pediatric Oncology. 21(1):1–7, 1993.

    Article  CAS  Google Scholar 

  42. Kalwinsky, D. K., Raimondi, S. C, Schell, M. J., Mirro, J., Jr.,, Santana, V. M., Behm, F., Dahl, G. V., and Williams, D. Prognostic importance of cytogenetic subgroups in de novo pediatric acute non-lymphocytic leukemia, Journal of Clinical Oncology. 8(1):75–83, 1990.

    PubMed  CAS  Google Scholar 

  43. Woods, W. G., Nesbit, M. E., Buckley, J., Lampkin, B. C, McCreadie, S., Kim, T. H., Piomelli, S., Kersey, J. H., Feig, S., Bernstein, I., and al., e. Correlation of chromosome abnormalities with patient characteristics, histologic subtype, and induction success in children with acute nonlymphocytic leukemia, Journal of Clinical Oncology. 3(1):3–11, 1985.

    PubMed  CAS  Google Scholar 

  44. Creutzig, U., Harbott, J., Sperling, C, Ritter J., Zimmermann, M., Löffler, H., Riehm, H., Schellong, G., and Ludwig, W. D. Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of a study AML-BFM-87, Blood. 86(8):3097–3108, 1995.

    PubMed  CAS  Google Scholar 

  45. Michel, G., Boulad, F., Small, T. N., Black, P., Heller, G., Castro-Malaspina, H., Childs, B. H., Gillio, A. P., Papadopoulos, E. B., Young, J. W, Kernan, N. A., and O’Reilly, R. J. Risk of extramedullary relapse following allogeneic bone marrow transplantation for acute myelogenous leukemia with leukemia cutis, Bone Marrow Transplantation. 20(2):107–12, 1997.

    Article  PubMed  CAS  Google Scholar 

  46. Neudorf, S., J.E., S., Howells, W, Gold, S., Lange, B. J., Kobrinsky, N., DeSwarte, J., Arthur, D. C, Barnard, D., Dunsenbery, K. E., Buckley, J., and Woods, W. G. The Beneficial Role of Autologous Bone Marrow Transplantations (ABMT) in the Treatment of Childhood Acute Myeloid Leukemia (AML): A Report From the Children’s Cancer Group, ASH, 1998.

    Google Scholar 

  47. Chan, G. C, Wang, W. C., Raimondi, S. C, Behm, F. G., Krance, R. A., Chen, G., Freiberg, A., Ingram, L., Butler, D., and Head, D. R. Myelodysplastic syndrome in children: differentiation from acute myeloid leukemia with a low blast count, Leukemia. 11(2):206–11, 1997.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Childrens’s Cancer Group Operations, 440 E. Huntington Drive, Suite 300, Arcadia, CA, 91006

    B. J. Lange, F. O. Smith, N. Kobrinsky, J. Buckley, W. Howells, J. W. Lee, J. E. Sanders, S. Neudorf, S. Gold, D. Barnard, J. Deswarte, K. Dusenbery, D. C. Arthur & W. G. Woods

Authors
  1. B. J. Lange
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. O. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Kobrinsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Buckley
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. Howells
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. W. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. E. Sanders
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S. Neudorf
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. S. Gold
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. D. Barnard
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. J. Deswarte
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. K. Dusenbery
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. D. C. Arthur
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. W. G. Woods
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine A, Germany

    T. Büchner

  2. Department of Internal Medicine III, University Hospital Großhadern Ludwig-Maximilians-University, Marchioninistr. 15, 81377, München, Germany

    W. Hiddemann

  3. Dept. of Internal Medicine, University of Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany

    B. Wörmann

  4. Department of Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, 48149, Münster, Germany

    G. Schellong , J. Ritter  & U. Creutzig ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Lange, B.J. et al. (2001). Long-Term Outcome and Prognostic Factors in Children’s Cancer Group Study 2891 for Children and Adolescents with Previously Untreated Acute Myeloid Leukemia and Myelodysplastic Syndrome. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J., Creutzig, U. (eds) Acute Leukemias VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18156-6_82

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-18156-6_82

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62109-3

  • Online ISBN: 978-3-642-18156-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation