Abstract
The history of effects-directed investigations of pulp and paper mill effluents has been driven primarily by the environmental effects associated with mill discharges. The first effect to confront the industry was acute toxicity to aquatic biota. Through a series of effects-directed studies in the 1970s and 1980s the causative agents were elucidated, subsequent regulations enacted, and effluent treatment technologies implemented to reduce the loadings of resin acids, chlorophenolics and other toxic compounds in mill discharges. Effects-directed investigations in the pulp and paper sector have since focused on other endpoints, primarily mutagenicity and endocrine disruption. Identification of these active substances has proven to be much more challenging due to the evolving complexities of effluent matrices and the intricacies of the responses themselves. Residual lignin in final effluents remains a significant barrier to the isolation and identification of low molecular weight bioactive substances. The evolution of analytical techniques (e.g., from XAD resins to SPE cartridges) coupled with new approaches (e.g., studying in-mill waste streams and fish tissue burdens of active substances) have nevertheless provided insights into the sources and identities of mutagens and endocrine disruptors. Active chemicals have been identified primarily using GC–MS with recent limited applications of LC–MS. A high proportion of substances originating from wood feedstocks have been identified or implicated in the effects studied. Differences in the patterns of effects between North and South American mill effluents may be reflective of the different tree species utilized. Careful selection of the endpoint used to direct such investigations, its reproducibility, robustness and linkages to whole organism responses and regulatory applications are emphasized.
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Hewitt, M. (2011). Effects-Directed Studies of Pulp and Paper Mill Effluents. In: Brack, W. (eds) Effect-Directed Analysis of Complex Environmental Contamination. The Handbook of Environmental Chemistry(), vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18384-3_11
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