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Angiotensin Receptor Signaling in the Brain: Ionic Currents and Neuronal Activity

  • Chapter
Angiotensin Vol. II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 163 / 2))

  • 189 Accesses

Abstract

The brain contains both major subtypes of angiotensin receptors, the angiotensin type 1 (AT1) and angiotensin type 2 (AT2) receptors. This chapter begin s with a review of the distribution of these receptor subtypes in the brain and continues with a discussion of their physiological and behavioral functions, from which it is clear that the AT l and AT2 recepto rs mediate very different centr al actions of angiotensin II (Ang II). However, the primary focus of this chapter is a discussion of the mechanisms through which Ang II, acting via AT1 and AT2 receptors, can produce rapid alterations in neuronal activity and ultimately functional changes. Hence, we review the studies that have demonstrated electrophysiological actions of Ang II in the brain, and then focus on the specific intr acellular signaling molecules that link the angio tensin receptor subtypes to changes in the activity of neuronal membrane ionic currents and firing rate. From this discussion it is clear that the intracellular signaling mechanisms that couple AT1 and AT2 receptors to changes in neuronal activity are vastly different. When taking a broader view of Ang II actions in neurons, it is evident that the signaling molecules responsible for regulation of neuronal activity represent only a few of the intracellular pathways that are modulated by this peptide

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  1. Department of Physiology and Functional Genornics, College of Medicine, University of Florida , 1600 SW Archer Road, P.O. Box 100274, Gainesville, FL, 32610, USA

    C. Sumners

  2. Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA

    E. M. Richards

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  1. C. Sumners
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© 2004 Springer-Verlag Berlin Heidelberg

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Sumners, C., Richards, E.M. (2004). Angiotensin Receptor Signaling in the Brain: Ionic Currents and Neuronal Activity. In: Angiotensin Vol. II. Handbook of Experimental Pharmacology, vol 163 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18497-0_8

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  • DOI: https://doi.org/10.1007/978-3-642-18497-0_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40641-9

  • Online ISBN: 978-3-642-18497-0

  • eBook Packages: Springer Book Archive

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