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Neurotransmitterhypothesen

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Handbuch der psychiatrischen Pharmakotherapie

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Zusammenfassung

Das Monoamin Serotonin (5-Hydroxytryptamin, 5-HT) wird in Neuronen des Hirnstamms synthetisiert. Es ist an der zentralnervösen Regulation einer großen Zahl physiologischer Prozesse beteiligt und beeinflusst während der Entwicklung des Gehirns die Ausprägung der Morphologie von Neuronen. Der Neurotransmitter scheint für eine normale Entwicklung des gesamten Organismus essenziell zu sein, denn transgene Mäuse, die aufgrund des Fehlens eines Transkriptionsfaktors kein Serotonin produzieren können, leiden unter Atemstörungen und weisen eine hohe Mortalität auf (Hodges et al. 2009). Zahlreiche Verhaltensuntersuchungen im Tiermodell lieferten Hinweise, dass 5-HT an der Kontrolle von emotionalen Prozessen beteiligt ist.

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Authors and Affiliations

  1. Klinische Neurobiologie, Deutsches Primatenzentrum, Kellnerweg 4, 37077, Göttingen

    Prof. Dr. Gabriele Flügge

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  1. Prof. Dr. Gabriele Flügge
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Editors and Affiliations

  1. Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Pauwelsstr. 30, 52074, Aachen

    Gerhard Gründer

  2. Luisenstr. 19, 55124, Mainz

    Otto Benkert

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Flügge, G. (2012). Neurotransmitterhypothesen. In: Gründer, G., Benkert, O. (eds) Handbuch der psychiatrischen Pharmakotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19844-1_11

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  • DOI: https://doi.org/10.1007/978-3-642-19844-1_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-19843-4

  • Online ISBN: 978-3-642-19844-1

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