Abstract
About nine million children die every year before they reach the age of 5 years, of conditions largely amendable with existing medicines. Lack of medicines is not the single most important health problem of children, but work to provide children with better access to appropriate medicines is essential for achievement of the child health goals set. Taking into consideration the global aspect in the development of paediatric medicines the benefits of the regional paediatric initiatives can be spread worldwide. This chapter provides insights in the challenges and opportunities of developing paediatric medicines for health needs of children in the developing world. The Essential Medicines List for children first made available in 2008 serves as an example of the many tools available from WHO to improve children’s access to the medicines they need.
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References
Grimshaw JM, Russell IT (1993) Effect of clinical guidelines on medical practice: a systematic review of rigorous evaluations. Lancet 342:1317–1322
Kafuko J, Bagenda D (1994) Impact of national standard treatment guidelines on rational drug use in Uganda health facilities. UNICEF/Uganda, Kampala
Laing R, Hogerzeil H et al (2001) Ten recommendations to improve use of medicines in developing countries. Health Policy Plan 16:13–20
Ministry of Health (1996) National drug policy of South Africa. Pretoria
Robertson J, Forte G et al (2009) What essential medicines for children are on the shelf? Bull World Health Organ 87:231–237
Taylor WR, Terlouw DJ et al (2006) Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria. Bull World Health Organ 84:956–964
WHO (2001) How to establish and implement a national drug policy. WHO, Geneva
WHO (2002) Promoting rational use of medicines: core components. WHO Policy Perspectives on Medicines, Geneva
WHO (2003) The selection and use of essential medicines. Report of the WHO Expert Committee, 2002 (including the 12th model list of essential medicines). Technical Report Series, No 914. WHO, Geneva
WHO (2008a) The selection and use of essential medicines. Report of the WHO Expert Committee, October 2007 (including the model list of essential medicines for children). Technical Report Series, No 950. WHO, Geneva
WHO (2008b) The WHO model formulary. WHO, Geneva
WHO (2008c) Report of the informal expert meeting on dosage forms of medicines for children. Available form: http://www.who.int/selection_medicines/committees/expert/17/application/paediatric/Dosage_form_reportDEC2008.pdf
WHO (2009a) Report of the technical consultation on the use of pharmacokinetic analyses for paediatric medicine development. Available form: http://www.who.int/childmedicines/progress/Pharmacokinetic_June2009.pdf
WHO (2009b) The selection and use of essential medicines. Report of the WHO Expert Committee, March 2009 (including the 16th WHO model list of essential medicines and the 2nd model list of essential medicines for children). Technical Report Series, No 958. WHO, Geneva
WHO (2010) WHO model formulary for children 2010. WHO, Geneva
Woolf SH, Grol R et al (1999) Clinical guidelines: potential benefits, limitations, and harms of clinical guidelines. BMJ 318:527–530
World Health Assembly (2007) Resolution WHA60.20 Better medicines for children.
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Hoppu, K., Hogerzeil, H.V. (2011). Global Aspects of Drug Development. In: Seyberth, H., Rane, A., Schwab, M. (eds) Pediatric Clinical Pharmacology. Handbook of Experimental Pharmacology, vol 205. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20195-0_18
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DOI: https://doi.org/10.1007/978-3-642-20195-0_18
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