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Molecular Basis of Morphogenesis in Fungi

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Morphogenesis and Pathogenicity in Fungi

Part of the book series: Topics in Current Genetics ((TCG,volume 22))

Abstract

In fungi, cellular morphogenesis is driven by localized membrane expansion and cell wall deposition. Variation in the geometry of fungal cells likely arises through the precise temporal and spatial regulation of these processes. Nevertheless, these modes of regulation are not well understood in filamentous fungi. This review focuses on three key aspects of fungal cellular morphogenesis: symmetry breaking, polarity maintenance, and septum formation. The mechanisms underlying cellular morphogenesis are summarized, with an emphasis on comparison to the model yeasts. In addition, mechanisms that coordinate morphogenesis with the yeast cell division cycle are briefly outlined. It is proposed that to some extent, analogous mechanisms function during fungal development to alter cell shape and size.

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Abbreviations

CDK:

Cyclin-dependent kinase

GAP:

GTPase-activating protein

GEF:

Guanine nucleotide exchange factor

MEN:

Mitotic exit network

NETO:

New end take-off

Nox:

NADPH oxidase

PAK:

p21-associated kinase

ROS:

Reactive oxygen species

SIN:

Septation initiation network

SPB:

Spindle pole body

SRD:

Sterol-rich domain

v-SNARE:

Vesicle-soluble, NSF attachment receptor

Ts:

Temperature sensitive

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Authors and Affiliations

  1. Department of Plant Pathology, Center for Plant Science Innovation, University of Nebraska, Lincoln, NE, USA

    Steven D. Harris

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  1. Steven D. Harris
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Correspondence to Steven D. Harris .

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  1. , Department of Microbial Biotechnology, Centro Nacional de Biotecnologia CSIC, Madrid, 28049, Spain

    José Pérez-Martín

  2. , Department of Genetics, University of Cordoba, Cordoba, 14071, Spain

    Antonio Di Pietro

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Harris, S.D. (2012). Molecular Basis of Morphogenesis in Fungi. In: Pérez-Martín, J., Di Pietro, A. (eds) Morphogenesis and Pathogenicity in Fungi. Topics in Current Genetics, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22916-9_1

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