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Zusammenfassung

Assoziationen zwischen körperlicher Aktivität und dem Krebsrisiko wurden in zahlreichen Studien beobachtet, insbesondere für Kolon-, Brust-, Endometrium-, Lungen- und Pankreaskrebs. Die Evidenz für einen (kausalen) Zusammenhang muss jedoch entitätsspezifisch betrachtet werden und wird in ▶ Abschn. 5.2genauer dargelegt. Über welche Mechanismen körperliche Aktivität protektiv in die Krebsätiologie eingreift, ist noch unzureichend belegt. Dabei ist zu bedenken, dass Krebs zahlreiche heterogene Krankheitsbilder mit unterschiedlichsten Ätiologien umfasst und körperliche Aktivität ein sehr komplexes Verhalten beschreibt, das zahlreiche physische und psychische Reaktionen hervorruft. Somit ist zu erwarten, dass es eine Vielzahl an biologischen Wirkmechanismen geben kann.

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Literatur

  • Allgayer H, Owen RW, Nair J, Spiegelhalder B, Streit J, Reichel C, Bartsch H (2008) Short-Term Moderate Exercise Programs Reduce Oxidative DNA Damage As Determined by High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry in Patients With Colorectal Carcinoma Following Primary Treatment. Scand J Gastroenterol 43:971–978

    Google Scholar 

  • Barnes BB, Chang-Claude J, Flesch-Janys D, Kinscherf R, Schmidt M, Slanger T, Bonaterra G, Steindorf K (2009) Cancer Risk Factors Associated With Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3 Levels in Healthy Women: Effect Modification by Menopausal Status. Cancer Causes Control

    Google Scholar 

  • Barnes BB, Steindorf K, Hein R, Flesch-Janys D, Chang-Claude J (2011) Population Attributable Risk of Invasive Postmenopausal Breast Cancer and Breast Cancer Subtypes for Modifiable and Non-Modifiable Risk Factors. Cancer Epidemiol 35:345–352

    Google Scholar 

  • Barocas DA, Motley S, Cookson MS, Chang SS, Penson DF, Dai Q, Milne G, Roberts LJ, Morrow J, Concepcion RS, Smith JA, Jr., Fowke JH (2011) Oxidative Stress Measured by Urine F2-Isoprostane Level Is Associated With Prostate Cancer. J Urol 185:2102–2107

    Google Scholar 

  • Brandt C, Pedersen BK (2010) The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense Against Chronic Diseases. J Biomed Biotechnol 2010:520258

    Google Scholar 

  • Campbell KL, McTiernan A (2007) Exercise and Biomarkers for Cancer Prevention Studies. J Nutr 137:161S–169S

    Google Scholar 

  • Campbell PT, Gross MD, Potter JD, Schmitz KH, Duggan C, McTiernan A, Ulrich CM (2010) Effect of Exercise on Oxidative Stress: a 12-Month Randomized, Controlled Trial. Med Sci Sports Exerc 42:1448–1453

    Google Scholar 

  • Campbell PT, Wener MH, Sorensen B, Wood B, Chen-Levy Z, Potter JD, McTiernan A, Ulrich CM (2008) Effect of Exercise on in Vitro Immune Function: a 12-Month Randomized, Controlled Trial Among Postmenopausal Women. J Appl Physiol 104:1648–1655

    Google Scholar 

  • Courneya KS, Friedenreich CM (2011) Physical Activity and Cancer. Springer, Heidelberg

    Google Scholar 

  • Cust AE (2011) Physical Activity and Gynecologic Cancer Prevention. Recent Results Cancer Res 186:159–185

    Google Scholar 

  • Cust AE, Armstrong BK, Friedenreich CM, Slimani N, Bauman A (2007) Physical Activity and Endometrial Cancer Risk: a Review of the Current Evidence, Biologic Mechanisms and the Quality of Physical Activity Assessment Methods. Cancer Causes Control 18:243–258

    Google Scholar 

  • Dai Q, Gao YT, Shu XO, Yang G, Milne G, Cai Q, Wen W, Rothman N, Cai H, Li H, Xiang Y, Chow WH, Zheng W (2009) Oxidative Stress, Obesity, and Breast Cancer Risk: Results From the Shanghai Women’s Health Study. J Clin Oncol 27:2482–2488

    Google Scholar 

  • Deeb KK, Trump DL, Johnson CS (2007) Vitamin D Signalling Pathways in Cancer: Potential for Anticancer Therapeutics. Nat Rev Cancer 7:684–700

    Google Scholar 

  • Emaus A, Thune I (2011) Physical Activity and Lung Cancer Prevention. Recent Results Cancer Res 186:101–133

    Google Scholar 

  • Fernandez-Sanchez A, Madrigal-Santillan E, Bautista M, Esquivel-Soto J, Morales-Gonzalez A, Esquivel-Chirino C, Durante-Montiel I, Sanchez-Rivera G, Valadez-Vega C, Morales-Gonzalez JA (2011) Inflammation, Oxidative Stress, and Obesity. Int J Mol Sci 12:3117–3132

    Google Scholar 

  • Fortunati N, Catalano MG, Boccuzzi G, Frairia R (2010) Sex Hormone-Binding Globulin (SHBG), Estradiol and Breast Cancer. Mol Cell Endocrinol 316:86–92

    Google Scholar 

  • Frank LL, Sorensen BE, Yasui Y, Tworoger SS, Schwartz RS, Ulrich CM, Irwin ML, Rudolph RE, Rajan KB, Stanczyk F, Bowen D, Weigle DS, Potter JD, McTiernan A (2005) Effects of Exercise on Metabolic Risk Variables in Overweight Postmenopausal Women: a Randomized Clinical Trial. Obes Res 13:615–625

    Google Scholar 

  • Friedenreich CM (2011) Physical Activity and Breast Cancer: Review of the Epidemiologic Evidence and Biologic Mechanisms. Recent Results Cancer Res 188:125–139

    Google Scholar 

  • Friedenreich CM, Neilson HK, Lynch BM (2010) State of the Epidemiological Evidence on Physical Activity and Cancer Prevention. Eur J Cancer 46:2593–2604

    Google Scholar 

  • Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Manson JE, Li J, Harris TG, Rohan TE, Xue X, Ho GY, Einstein MH, Kaplan RC, Burk RD, Wylie-Rosett J, Pollak MN, Anderson G, Howard BV, Strickler HD (2008) A Prospective Evaluation of Insulin and Insulin-Like Growth Factor-I As Risk Factors for Endometrial Cancer. Cancer Epidemiol Biomarkers Prev 17:921–929

    Google Scholar 

  • Hanahan D, Weinberg RA (2011) Hallmarks of Cancer: the Next Generation. Cell 144:646–674

    Google Scholar 

  • Hankinson SE, Eliassen AH (2007) Endogenous Estrogen, Testosterone and Progesterone Levels in Relation to Breast Cancer Risk. J Steroid Biochem Mol Biol 106:24–30

    Google Scholar 

  • Hintzpeter B, Mensink GB, Thierfelder W, Muller MJ, Scheidt-Nave C (2008) Vitamin D Status and Health Correlates Among German Adults. Eur J Clin Nutr 62:1079–1089

    Google Scholar 

  • Husemann B, Neubauer MG, Duhme C (1980) Sitzende Tätigkeit Und Rektum-Sigma-Karzinom. Onkologie 3:168–171

    Google Scholar 

  • Kaaks R (2004) Nutrition, Insulin, IGF-1 Metabolism and Cancer Risk: a Summary of Epidemiological Evidence. Novartis Found Symp 262:247–260

    Google Scholar 

  • Kaaks R, Lukanova A, Kurzer MS (2002) Obesity, Endogenous Hormones, and Endometrial Cancer Risk: a Synthetic Review. Cancer Epidemiol Biomarkers Prev 11:1531–1543

    Google Scholar 

  • Kluczynski MA, LaMonte MJ, Mares JA, Wactawski-Wende J, Smith AW, Engelman CD, Andrews CA, Snetselaar LG, Sarto GE, Millen AE (2011) Duration of Physical Activity and Serum 25-Hydroxyvitamin D Status of Postmenopausal Women. Ann Epidemiol 21:440–449

    Google Scholar 

  • Leitzmann MF (2011) Physical Activity and Genitourinary Cancer Prevention. Recent Results Cancer Res 186:43–71

    Google Scholar 

  • Liedtke S, Schmidt ME, Becker S, Kaaks R, Zaineddin AK, Buck K, Flesch-Janys D, Wahrendorf J, Chang-Claude J, Steindorf K (2011) Physical Activity and Endogenous Sex Hormones in Postmenopausal Women: to What Extent Are Observed Associations Confounded or Modified by BMI? Cancer Causes Control 22:81–89

    Google Scholar 

  • Lynch BM, Neilson HK, Friedenreich CM (2011) Physical Activity and Breast Cancer Prevention. Recent Results Cancer Res 186:13–42

    Google Scholar 

  • Meyers JA, Liu AY, McTiernan A, Wener MH, Wood B, Weigle DS, Sorensen B, Chen-Levy Z, Yasui Y, Boynton A, Potter JD, Ulrich CM (2008) Serum Leptin Concentrations and Markers of Immune Function in Overweight or Obese Postmenopausal Women. J Endocrinol 199:51–60

    Google Scholar 

  • Milne GL, Yin H, Brooks JD, Sanchez S, Jackson RL, Morrow JD (2007) Quantification of F2-Isoprostanes in Biological Fluids and Tissues As a Measure of Oxidant Stress. Methods Enzymol 433:113–126

    Google Scholar 

  • Monninkhof EM, Elias SG, Vlems FA, van der Tweel I, Schuit AJ, Voskuil DW, van Leeuwen FE (2007) Physical Activity and Breast Cancer, a Systematic Review of Current Evidence. Epidemiology 18:137–157

    Google Scholar 

  • Moore SC, Gierach GL, Schatzkin A, Matthews CE (2010) Physical Activity, Sedentary Behaviours, and the Prevention of Endometrial Cancer. Br J Cancer 103:933–938

    Google Scholar 

  • Neilson HK, Friedenreich CM, Brockton NT, Millikan RC (2009) Physical Activity and Postmenopausal Breast Cancer: Proposed Biologic Mechanisms and Areas for Future Research. Cancer Epidemiol Biomarkers Prev 18:11–27

    Google Scholar 

  • O’Rorke MA, Cantwell MM, Cardwell CR, Mulholland HG, Murray LJ (2010) Can Physical Activity Modulate Pancreatic Cancer Risk? a Systematic Review and Meta-Analysis. Int J Cancer 126:2957–2968

    Google Scholar 

  • Pisani P (2008) Hyper-Insulinaemia and Cancer, Meta-Analyses of Epidemiological Studies. Arch Physiol Biochem 114:63–70

    Google Scholar 

  • Quadrilatero J, Hoffman-Goetz L (2003) Physical Activity and Colon Cancer. A Systematic Review of Potential Mechanisms. J Sports Med Phys Fitness 43:121–138

    Google Scholar 

  • Renehan AG, Zwahlen M, Minder C, O’dwyer ST, Shalet SM, Egger M (2004) Insulin-Like Growth Factor (IGF)-I, IGF Binding Protein-3, and Cancer Risk: Systematic Review and Meta-Regression Analysis. Lancet 363:1346–1353

    Google Scholar 

  • Roddam AW, Allen NE, Appleby P, Key TJ (2008) Endogenous Sex Hormones and Prostate Cancer: a Collaborative Analysis of 18 Prospective Studies. J Natl Cancer Inst 100:170–183

    Google Scholar 

  • Rowlands MA, Gunnell D, Harris R, Vatten LJ, Holly JM, Martin RM (2009) Circulating Insulin-Like Growth Factor Peptides and Prostate Cancer Risk: a Systematic Review and Meta-Analysis. Int J Cancer 124:2416–2429

    Google Scholar 

  • Schmidt ME, Steindorf K, Mutschelknauss E, Slanger T, Obi N, Kropp S, Berger J, Braendle W, Flesch-Janys D, Chang-Claude J (2008) Physical Activity and Postmenopausal Breast Cancer: Effective Periods in Life and Effect Modification by Different Breast Cancer Characteristics. Cancer Epidemiol Biomarkers Prev 17:3402–3410

    Google Scholar 

  • Schmitz KH, Warren M, Rundle AG, Williams NI, Gross MD, Kurzer MS (2008) Exercise Effect on Oxidative Stress Is Independent of Change in Estrogen Metabolism. Cancer Epidemiol Biomarkers Prev 17:220–223

    Google Scholar 

  • Sjostrom M, Oja P, Hagstromer M, Smith BJ, Bauman A (2006) Health-Enhancing Physical Activity Across European Union Countries: the EUROBAROMETER Study. J Public Health 14:291–300

    Google Scholar 

  • Tardon A, Lee WJ, Delgado-Rodriguez M, Dosemeci M, Albanes D, Hoover R, Blair A (2005) Leisure-Time Physical Activity and Lung Cancer: a Meta-Analysis. Cancer Causes Control 16:389–397

    Google Scholar 

  • Voskuil DW, Monninkhof EM, Elias SG, Vlems FA, van Leeuwen FE (2007) Physical Activity and Endometrial Cancer Risk, a Systematic Review of Current Evidence. Cancer Epidemiol Biomarkers Prev 16:639–648

    Google Scholar 

  • Winzer BM, Whiteman DC, Reeves MM, Paratz JD (2011a) Physical Activity and Cancer Prevention: a Systematic Review of Clinical Trials. Cancer Causes Control 22:811–826

    Google Scholar 

  • Winzer BM, Whiteman DC, Reeves MM, Paratz JD (2011b) Physical Activity and Cancer Prevention: a Systematic Review of Clinical Trials. Cancer Causes Control 22:811–826

    Google Scholar 

  • Wolin KY, Tuchman H (2011) Physical Activity and Gastrointestinal Cancer Prevention. Recent Results Cancer Res 186:73–100

    Google Scholar 

  • Wolin KY, Yan Y, Colditz GA, Lee IM (2009) Physical Activity and Colon Cancer Prevention: a Meta-Analysis. Br J Cancer 100:611–616

    Google Scholar 

  • World Cancer Research Fund / American Institute for Cancer Research (2007) Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Prospective. AICR, Washington, DC

    Google Scholar 

  • Yager JD, Davidson NE (2006) Estrogen Carcinogenesis in Breast Cancer. N Engl J Med 354:270–282

    Google Scholar 

  • Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H (2010) Meta-Analysis: Serum Vitamin D and Breast Cancer Risk. Eur J Cancer 46:2196–2205

    Google Scholar 

  • Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H (2011a) Meta-Analysis: Circulating Vitamin D and Ovarian Cancer Risk. Gynecol Oncol 121:369–375

    Google Scholar 

  • Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H (2011b) Meta-Analysis: Serum Vitamin D and Colorectal Adenoma Risk. Prev Med

    Google Scholar 

  • Yin L, Raum E, Haug U, Arndt V, Brenner H (2009) Meta-Analysis of Longitudinal Studies: Serum Vitamin D and Prostate Cancer Risk. Cancer Epidemiol 33:435–445

    Google Scholar 

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Steindorf, K., Schmidt, M. (2012). Primärprävention. In: Sport und körperliche Aktivität in der Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25066-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-25066-8_5

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