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Transportation: Choice of Anaesthetic Drugs

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Management of Severe Traumatic Brain Injury

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Abstract

Ischemic neuronal injury is characterised by early death mediated by excitotoxicity and by apoptosis. Current evidence indicates that volatile anaesthetic agents, apart from nitrous oxide, barbiturates, and propofol, can protect neurones against ischemic injury caused by excitotoxicity. In the case of volatile agents and propofol, neuroprotection may be sustained if the ischemic insult is relatively mild; however, with moderate to severe insults, this neuronal protection is not sustained after a prolonged recovery period. This suggests that these agents do not protect from delayed neuronal death caused by apoptosis. The long-term effects of any anaesthetic drug on ischemic cerebral injury are not yet defined.

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Authors and Affiliations

  1. Department of anaesthesia, Aarhus University Hospital, Noerrebrogade 44, 8000, Aarhus C, Denmark

    Niels Juul

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  1. Niels Juul
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Correspondence to Niels Juul .

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Editors and Affiliations

  1. , Department of Neurosurgery, Haukeland University Hospital, Jonas Liesvei 65, Bergen, 5021, Norway

    Terje Sundstrom

  2. , Department of Anaesthesia and Intensive, Lund University Hospital, Getingevägen 4, Lund, 22185, Sweden

    Per-Olof Grände

  3. Dept. Neuroanaesthesia & Neurosurgery, Arhus University Hospital, Aarhus C, 8000, Denmark

    Niels Juul

  4. , Department of Neurosurgery, Aarhus University Hospital, Norrebrograde 44, Aarhus C, 8000, Denmark

    Carsten Kock-Jensen

  5. , Department of Neurosurgery, Copenhagen University Hospital, Bledgamsvej 9, Copenhagen, 2100, Denmark

    Bertil Romner

  6. , Department of Surgical Sciences, University of Bergen, Jonas Liesvei, Bergen, 5021, Norway

    Knut Wester

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© 2012 Springer-Verlag Berlin Heidelberg

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Juul, N. (2012). Transportation: Choice of Anaesthetic Drugs. In: Sundstrom, T., Grände, PO., Juul, N., Kock-Jensen, C., Romner, B., Wester, K. (eds) Management of Severe Traumatic Brain Injury. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28126-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-28126-6_6

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-28125-9

  • Online ISBN: 978-3-642-28126-6

  • eBook Packages: MedicineMedicine (R0)

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