Abstract
This study compares the quantitative potential of cone-beam dedicated breast CT (bCT) and digital breast tomosynthesis (DBT) for contrastenhanced (CE) imaging in the assessment of 3D lesion extent and iodinated contrast-agent uptake. bCT and DBT topologies were modeled assuming perfect energy-integrating detectors. Projection images were simulated using optimized spectra for iodine imaging and primary photons only. Lesion extent and lesion-to-background-contrast were measured in reconstructed images of breast tissue equivalent phantoms containing iodinated lesions. Lesion extent was estimated using an automatic estimator. A full factorial experiment was used to evaluate the effect of 3D lesion dimension, position and iodine concentration on measurement precision. Preliminary results show that for CE-DBT and CEbCT, precision is similar in the in-plane direction, while CE-bCT is superior in the depth direction. Lesion-to-background-contrast greatly depends on lesion diameter in CE-DBT and is almost independent of lesion diameter for CE-bCT.
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de Carvalho, P.M., Carton, AK., Iordache, R., Saab-Puong, S., Muller, S. (2012). Comparison of Lesion Extent and Contrast-Agent Uptake in Breast Tomosynthesis versus Cone-Beam Breast CT. In: Maidment, A.D.A., Bakic, P.R., Gavenonis, S. (eds) Breast Imaging. IWDM 2012. Lecture Notes in Computer Science, vol 7361. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31271-7_56
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DOI: https://doi.org/10.1007/978-3-642-31271-7_56
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