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Recent Advances in Cross-Coupling Reactions with Alkyl Halides

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Applied Cross-Coupling Reactions

Part of the book series: Lecture Notes in Chemistry ((LNC,volume 80))

Abstract

The alkyl electrophiles with β-hydrogens have been scarcely employed in the transition-metal-catalyzed cross-coupling reactions until recently. This is due to their low electrophilicity and the facile occurrence of β-hydrogen elimination under standard conditions. However, in recent years, the alkyl electrophiles have received a marked increase in attention; numerous synthetic examples using the alkyl electrophiles as coupling partners have been reported. This chapter classifies the recently reported cross-coupling reactions of these alkyl electrophiles, grouping the reactions by organometallic reagent. Introductions to representative synthetic examples are given.

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Authors and Affiliations

  1. Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama, 700-8530, Japan

    Arisa Yamamoto, Yugo Nishimura & Yasushi Nishihara

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  1. Arisa Yamamoto
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  2. Yugo Nishimura
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  3. Yasushi Nishihara
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Correspondence to Yasushi Nishihara .

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  1. Department of Chemistry, Okayama University, Okayama, Japan

    Yasushi Nishihara

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Yamamoto, A., Nishimura, Y., Nishihara, Y. (2013). Recent Advances in Cross-Coupling Reactions with Alkyl Halides. In: Nishihara, Y. (eds) Applied Cross-Coupling Reactions. Lecture Notes in Chemistry, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32368-3_8

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