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Synthesis of Isocoumarins and Dihydroisocoumarins

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Novel Selenium-Mediated Rearrangements and Cyclisations

Part of the book series: Springer Theses ((Springer Theses,volume 77))

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Abstract

This chapter initially reviews methods for the preparation of isocoumarin derivatives and describes some previous synthetic methods. A new selenium-catalysed synthesis of isocoumarins is discussed and its application for preparation of a range of isocoumarins by reaction of stilbene carboxylic acids with diphenyl diselenide and a hypervalent iodine reagent is described. It was also discovered that dimethyl diselenide and diphenyl disulfide can be used in place of diphenyl diselenide. Using this modification the method was extended to prepare more challenging dihydroisocoumarins.

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Authors and Affiliations

  1. Department of Chemistry, COMSATS, Institute of Information Technology, University Road, Abbottabad, 22060, Pakistan

    Sohail Anjum Shahzad

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  1. Sohail Anjum Shahzad
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Correspondence to Sohail Anjum Shahzad .

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Shahzad, S.A. (2013). Synthesis of Isocoumarins and Dihydroisocoumarins. In: Novel Selenium-Mediated Rearrangements and Cyclisations. Springer Theses, vol 77. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33173-2_4

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