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Metabolic Dissipative Structures

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Systems Biology of Metabolic and Signaling Networks

Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 16))

Abstract

The self-organization of metabolic processes, such as the spontaneous dissipative formation of macromolecular structures, the functional coordination between multienzymatic complexes, and the emergence of molecular rhythms, is one of the most relevant topics in the post-genomic era. Herein, I analyze some aspects of self-organization in metabolic processes utilizing information theory to quantifying biomolecular information flows in bits, an approach that enables the visualization of emergent effective connectivity structures. Specifically, I determined the emergent functional integrative processes arising from irreversible enzymatic steps in yeast glycolysis, and in the systemic metabolic structure. Experimental observations and numerical studies with dissipative metabolic networks have shown that enzymatic activity can spontaneously self-organize leading to the emergence of a systemic metabolic structure, characterized by a set of different enzymatic reactions always locked into active states, i.e., the metabolic core, while the remaining catalytic processes are intermittently active. This global metabolic structure was verified in Escherichia coli, Helicobacter pylori, and Saccharomyces cerevisiae, and it seems to be a common key feature for all cells. The observed effective connectivity in both the irreversible enzymatic steps of yeast glycolysis and the systemic metabolic structure is highly dynamic and characterized by significant variations of biomolecular causality flows. These effective connectivity flows reflect the integration of catalytic processes within multienzymatic systems, and their functional coordination. The resulting functional integrative structures appear to be fundamental motifs in the dissipative self-organization and self-regulation of cellular metabolism.

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Authors and Affiliations

  1. BioCruces Health Research Institute, Barakaldo, Basque Country, Spain

    Ildefonso Mtz. de la Fuente

  2. Institute of Parasitology and Biomedicine “López Neyra”, CSIC, Granada, Spain

    Ildefonso Mtz. de la Fuente

  3. Department of Mathematics, University of the Basque Country, EHU-UPV., Leioa, Spain

    Ildefonso Mtz. de la Fuente

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  1. Ildefonso Mtz. de la Fuente
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  1. School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

    Miguel A. Aon

  2. Laboratory of Fundamental and Applied Bi, Inserm U1055 and University Joseph Fourier, Grenoble, Grenoble cedex 9, France

    Valdur Saks

  3. Laboratory of Fundamental and Applied Bi, Inserm U1055 and University Joseph Fourier, Grenoble, Grenoble cedex 9, France

    Uwe Schlattner

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de la Fuente, I.M. (2014). Metabolic Dissipative Structures. In: Aon, M., Saks, V., Schlattner, U. (eds) Systems Biology of Metabolic and Signaling Networks. Springer Series in Biophysics, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38505-6_8

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