Abstract
Diabetic nephropathy is a clinical syndrome in a patient with diabetes mellitus that is characterized by persistent albuminuria, worsening proteinuria, hypertension, and progressive renal failure [1–3]. Approximately a third of patients with type 1 insulin-dependent diabetes mellitus (IDDM) and type 2 non-insulin-dependent diabetes mellitus (NIDDM) develop diabetic nephropathy [2]. The pathologic hallmark of diabetic nephropathy is diabetic glomerulosclerosis that results from a progressive increase in extracellular matrix in the glomerular mesangium and glomerular basement membranes [4]. Diabetic glomerulosclerosis is the leading cause of end-stage renal disease in the United States, Europe, and Japan [1].
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Fogo, A.B., Cohen, A.H., Colvin, R.B., Jennette, J.C., Alpers, C.E. (2014). Diabetic Nephropathy. In: Fundamentals of Renal Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39080-7_12
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DOI: https://doi.org/10.1007/978-3-642-39080-7_12
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