Skip to main content

Complications of Inflammatory Bowel Disease

  • Chapter
  • First Online:
Atlas of Inflammatory Bowel Diseases

Abstract

Inflammatory bowel disease is a chronic, heterogenic, and lifelong illness with a high potential of individual and social disability. A general deterioration of the quality of life in patients with inflammatory bowel disease predominantly stems from localized complications regarding the natural course of the disease. Both Crohn’s disease (CD) and ulcerative colitis (UC) are associated with various kinds of complications. A direct causal relationship exists between disease duration and development of complications. However, CD is frequently related with the formation of fistulae and abscess due to its transmural nature, while UC is often accompanied by the results of severe inflammations such as toxic megacolon. Despite the abundant literature discussing the pathogenesis and treatment of those complications, early detection and intervention for complication is still challenging at present. Therefore, clinical evaluation should precisely characterize the number, location, degree, and feature of the complications. In this chapter, we will review about complications of gastrointestinal tract in patients with inflammatory bowel disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Schwartz DA, Loftus Jr EV, Tremaine WJ, Panaccione R, Harmsen WS, Zinsmeister AR, et al. The natural history of fistulizing Crohn’s disease in Olmsted County, Minnesota. Gastroenterology. 2002;122(4):875–80. PubMed PMID: 11910338.

    Article  PubMed  Google Scholar 

  2. Falconi M, Pederzoli P. The relevance of gastrointestinal fistulae in clinical practice: a review. Gut. 2001;49 Suppl 4:iv2–10. PubMed PMID: 11878790. Pubmed Central PMCID: 1766897.

    PubMed Central  PubMed  Google Scholar 

  3. Tozer P, Ng SC, Siddiqui MR, Plamondon S, Burling D, Gupta A, et al. Long-term MRI-guided combined anti-TNF-alpha and thiopurine therapy for Crohn’s perianal fistulas. Inflamm Bowel Dis. 2012;18(10):1825–34. PubMed PMID: 22223472.

    Article  PubMed  Google Scholar 

  4. Pearson DC, May GR, Fick GH, Sutherland LR. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann Intern Med. 1995;123(2):132–42. PubMed PMID: 7778826.

    Article  CAS  PubMed  Google Scholar 

  5. Kamm MA, Ng SC. Perianal fistulizing Crohn’s disease: a call to action. Clin Gastroenterol Hepatol. 2008;6(1):7–10. PubMed PMID: 18063415.

    Article  PubMed  Google Scholar 

  6. Fleshner PR, Schoetz Jr DJ, Roberts PL, Murray JJ, Coller JA, Veidenheimer MC. Anal fissure in Crohn’s disease: a plea for aggressive management. Dis Colon Rectum. 1995;38(11):1137–43. PubMed PMID: 7587755.

    Article  CAS  PubMed  Google Scholar 

  7. Bouguen G, Siproudhis L, Bretagne JF, Bigard MA, Peyrin-Biroulet L. Nonfistulizing perianal Crohn’s disease: clinical features, epidemiology, and treatment. Inflamm Bowel Dis. 2010;16(8):1431–42. PubMed PMID: 20310013.

    Article  PubMed  Google Scholar 

  8. Keighley MR, Allan RN. Current status and influence of operation on perianal Crohn’s disease. Int J Color Dis. 1986;1(2):104–7. PubMed PMID: 3611935.

    Article  CAS  Google Scholar 

  9. Hughes LE. Clinical classification of perianal Crohn’s disease. Dis Colon Rectum. 1992;35(10):928–32. PubMed PMID: 1395978.

    Article  CAS  PubMed  Google Scholar 

  10. Sandborn WJ, Fazio VW, Feagan BG, Hanauer SB, American Gastroenterological Association Clinical Practice C. AGA technical review on perianal Crohn’s disease. Gastroenterology. 2003;125(5):1508–30. PubMed PMID: 14598268.

    Article  PubMed  Google Scholar 

  11. Bonheur JL, Braunstein J, Korelitz BI, Panagopoulos G. Anal skin tags in inflammatory bowel disease: new observations and a clinical review. Inflamm Bowel Dis. 2008;14(9):1236–9. PubMed PMID: 18452201.

    Article  PubMed  Google Scholar 

  12. Keighley MR, Eastwood D, Ambrose NS, Allan RN, Burdon DW. Incidence and microbiology of abdominal and pelvic abscess in Crohn’s disease. Gastroenterology. 1982;83(6):1271–5. PubMed PMID: 7129031.

    CAS  PubMed  Google Scholar 

  13. Ayuk P, Williams N, Scott NA, Nicholson DA, Irving MH. Management of intra-abdominal abscesses in Crohn’s disease. Ann R Coll Surg Engl. 1996;78(1):5–10. PubMed PMID: 8659975. Pubmed Central PMCID: 2502682.

    PubMed Central  CAS  PubMed  Google Scholar 

  14. Kim DH, Cheon JH, Moon CM, Park JJ, Han SY, Kim ES, et al. Clinical efficacy of nonsurgical treatment of Crohn’s disease-related intrbdominal abscess. Korean J Gastroenterol. 2009;53(1):29–35. PubMed PMID: 19158468.

    PubMed  Google Scholar 

  15. Lesage S, Zouali H, Cezard JP, Colombel JF, Belaiche J, Almer S, et al. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet. 2002;70(4):845–57. PubMed PMID: 11875755. Pubmed Central PMCID: 379113.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Thienpont C, D’Hoore A, Vermeire S, Demedts I, Bisschops R, Coremans G, et al. Long-term outcome of endoscopic dilatation in patients with Crohn’s disease is not affected by disease activity or medical therapy. Gut. 2010;59(3):320–4. PubMed PMID: 19840991.

    Article  CAS  PubMed  Google Scholar 

  17. Gan SI, Beck PL. A new look at toxic megacolon: an update and review of incidence, etiology, pathogenesis, and management. Am J Gastroenterol. 2003;98(11):2363–71. PubMed PMID: 14638335. Epub 2003/11/26. eng.

    Article  PubMed  Google Scholar 

  18. Greenstein AJ, Sachar DB, Gibas A, Schrag D, Heimann T, Janowitz HD, et al. Outcome of toxic dilatation in ulcerative and Crohn’s colitis. J Clin Gastroenterol. 1985;7(2):137–43. PubMed PMID: 4008909.

    Article  CAS  PubMed  Google Scholar 

  19. Alemayehu G, Jarnerot G. Colonoscopy during an attack of severe ulcerative colitis is a safe procedure and of great value in clinical decision making. Am J Gastroenterol. 1991;86(2):187–90. PubMed PMID: 1992632. Epub 1991/02/01. eng.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Jae Hee Cheon MD, PhD or Siew Chien Ng PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Chan, H.Ch., Kim, D.H., Lung, P.F.C., Cheon, J.H., Ng, S.C. (2015). Complications of Inflammatory Bowel Disease. In: Kim, W., Cheon, J. (eds) Atlas of Inflammatory Bowel Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39423-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-39423-2_12

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-39422-5

  • Online ISBN: 978-3-642-39423-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics