Skip to main content
SpringerLink
Log in

Acute Kidney Injury in the Newborn

  • Chapter
  • First Online:
Kidney and Urinary Tract Diseases in the Newborn

  • 1398 Accesses

Abstract

Acute kidney injury (AKI) is characterized by a sudden impairment in kidney function that results in the inability to maintain adequate fluid, electrolyte, and waste product homeostasis. It is increasingly recognized as a common and significant event for newborns cared for in the neonatal intensive care unit, with important implications for treatment decisions and clinical outcomes. Indeed, AKI is associated with mortality in critically ill children [2, 86] and adults [14, 25, 52, 65, 78], even after controlling for medical comorbidities, severity of illness scores, and patient demographics. Emerging data suggest a similar association in the neonatal population as well [32, 47, 48], such that kidney injury can no longer be viewed as an incidental finding but rather an important determinant of patient outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

ACE I:

Angiotensin-converting enzyme inhibitor

ATN:

Acute tubular necrosis

AKI:

Acute kidney injury

BUN:

Blood urea nitrogen

CAKUT:

Congenital anomalies of the kidney and urinary tract

CVVHDF:

Continuous venovenous hemodi-afiltration

ECMO:

Extracorporeal membrane oxygen-ation

FENa:

Fractional excretion of sodium

GFR:

Glomerular filtration rate

K:

Potassium

kg:

Kilogram

L:

Liters

Ml:

Milliliters

mEq/dl:

Milliequivalents per deciliter

Mg/dl:

Milligrams per deciliter

Na:

Sodium

NGAL:

Neutrophil-gelatinase-associated lipocalin

NICU:

Neonatal intensive care unit

NSAIDs:

Nonsteroidal anti-inflammatory drugs

SCr:

Serum creatinine

VLBW:

Very low birth weight

References

  1. Aggarwal A, Kumar P, Chowdhary G, Majumdar S, Narang A (2005) Evaluation of renal functions in asphyxiated newborns. J Trophic Pediatr 51(5):295–299. doi:10.1093/tropej/fmi017

    Article  Google Scholar 

  2. Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL (2007) Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int 71(10):1028–1035. doi:10.1038/sj.ki.5002231

    Article  CAS  PubMed  Google Scholar 

  3. Andreoli SP (2002) Acute renal failure. Curr Opin Pediatr 14(2):183–188

    Article  PubMed  Google Scholar 

  4. Andreoli SP (2004) Acute renal failure in the newborn. Semin Perinatol 28(2):112–123

    Article  PubMed  Google Scholar 

  5. Arikan AA, Zappitelli M, Goldstein SL, Naipaul A, Jefferson LS, Loftis LL (2012) Fluid overload is associated with impaired oxygenation and morbidity in critically ill children*. Pediatr Crit Care Med 13(3):253–258. doi:10.1097/PCC.0b013e31822882a3

    Article  PubMed  Google Scholar 

  6. Askenazi DJ, Ambalavanan N, Hamilton K, Cutter G, Laney D, Kaslow R, Georgeson K, Barnhart DC, Dimmitt RA (2011) Acute kidney injury and renal replacement therapy independently predict mortality in neonatal and pediatric noncardiac patients on extracorporeal membrane oxygenation. Pediatr Crit Care Med 12(1):e1–6. doi:10.1097/PCC.0b013e3181d8e348

    Article  PubMed  Google Scholar 

  7. Askenazi DJ, Furth S, Warady B (2012) Acute and chronic kidney failure. In: Gleason CA, Devaskar S (eds) Avery’s diseases of the newborn, 9th edn. Elsevier, Philadelphia

    Google Scholar 

  8. Askenazi DJ, Griffin R, McGwin G, Carlo W, Ambalavanan N (2009) Acute kidney injury is independently associated with mortality in very low birthweight infants: a matched case-control analysis. Pediatr Nephrol 24(5):991–997. doi:10.1007/s00467-009-1133-x

    Article  PubMed  Google Scholar 

  9. Askenazi DJ, Koralkar R, Hundley HE, Montesanti A, Parwar P, Sonjara S, Ambalavanan N (2012) Urine biomarkers predict acute kidney injury in newborns. J Pediatr 161(2):270–275. doi:10.1016/j.jpeds.2012.02.007

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Askenazi DJMA, Hunley H, Koralkar R, Pawar P, Shuaib F, Liwo A, Devarajan P, Ambalavanan N (2011) Urine biomarkers predict acute kidney injury and mortality in very low birth weight infants. J Pediatr 159(6):907–12.e1

    Article  CAS  PubMed  Google Scholar 

  11. Auron A, Auron-Gomez M, Raina R, Viswanathan S, Mhanna MJ (2009) Effect of amphotericin B lipid complex (ABLC) in very low birth weight infants. Pediatr Nephrol 24(2):295–299. doi:10.1007/s00467-008-1017-5

    Article  PubMed  Google Scholar 

  12. Awad AS, Okusa MD (2007) Distant organ injury following acute kidney injury. Am J Physiol Renal Physiol 293(1):F28–29

    Article  CAS  PubMed  Google Scholar 

  13. Bagshaw SM, Delaney A, Haase M, Ghali WA, Bellomo R (2007) Loop diuretics in the management of acute renal failure: a systematic review and meta-analysis. Crit Care Resusc 9(1):60–68

    PubMed  Google Scholar 

  14. Bagshaw SM, George C, Bellomo R (2007) Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units. Crit Care 11(3):R68. doi:10.1186/cc5949. cc5949 [pii]

  15. Baley JE, Kliegman RM, Fanaroff AA (1984) Disseminated fungal infections in very low-birth-weight infants: therapeutic toxicity. Pediatrics 73(2):153–157

    CAS  PubMed  Google Scholar 

  16. Bannwarth B, Lagrange F, Pehourcq F, Llanas B, Demarquez JL (1999) (S)-ketoprofen accumulation in premature neonates with renal failure who were exposed to the racemate during pregnancy. Br J Clin Pharmacol 47(4):459–460

    CAS  PubMed  Google Scholar 

  17. Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J (2000) Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 356(9248):2139–2143

    Article  CAS  PubMed  Google Scholar 

  18. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative w (2004) Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8(4):R204–212. doi:10.1186/cc2872

    Article  PubMed Central  PubMed  Google Scholar 

  19. Blinder JJ, Goldstein SL, Lee VV, Baycroft A, Fraser CD, Nelson D, Jefferies JL (2012) Congenital heart surgery in infants: effects of acute kidney injury on outcomes. J Thorac Cardiovasc Surg 143(2):368–374. doi:10.1016/j.jtcvs.2011.06.021

    Article  PubMed  Google Scholar 

  20. Brandao LR, Simpson EA, Lau KK (2011) Neonatal renal vein thrombosis. Semin Fetal Neonatal Med 16(6):323–328. doi:10.1016/j.siny.2011.08.004

    Article  PubMed  Google Scholar 

  21. Cavagnaro F, Kattan J, Godoy L, Gonzales A, Vogel A, Rodriguez JI, Faunes M, Fajardo C, Becker P (2007) Continuous renal replacement therapy in neonates and young infants during extracorporeal membrane oxygenation. Int J Artif Organs 30(3):220–226

    CAS  PubMed  Google Scholar 

  22. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW (2005) Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 16(11):3365–3370. doi:10.1681/ASN.2004090740

    Article  PubMed  Google Scholar 

  23. Cifuentes RF, Olley PM, Balfe JW, Radde IC, Soldin SJ (1979) Indomethacin and renal function in premature infants with persistent patent ductus arteriosus. J Pediatr 95(4):583–587

    Article  CAS  PubMed  Google Scholar 

  24. Coulthard MG, Vernon B (1995) Managing acute renal failure in very low birthweight infants. Arch Dis Child Fetal Neonatal Ed 73(3):F187–F192

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. Cuhaci B (2009) More data on epidemiology and outcome of acute kidney injury with AKIN criteria: benefits of standardized definitions, AKIN and RIFLE classifications. Crit Care Med 37(9):2659–2661. doi:10.1097/CCM.0b013e3181ad76c200003246-200909000-00031 [pii]

    Article  PubMed  Google Scholar 

  26. Ellis EN, Arnold WC (1982) Use of urinary indexes in renal failure in the newborn. Am J Dis Child 136(7):615–617

    CAS  PubMed  Google Scholar 

  27. Feld LG, Springate JE, Fildes RD (1986) Acute renal failure. I. Pathophysiology and diagnosis. J Pediatr 109(3):401–408

    Article  CAS  PubMed  Google Scholar 

  28. Ferrara E, Lemire J, Reznik VM, Grimm PC (2004) Dietary phosphorus reduction by pretreatment of human breast milk with sevelamer. Pediatr Nephrol 19(7):775–779. doi:10.1007/s00467-004-1448-6

    Article  PubMed  Google Scholar 

  29. Foland JA, Fortenberry JD, Warshaw BL, Pettignano R, Merritt RK, Heard ML, Rogers K, Reid C, Tanner AJ, Easley KA (2004) Fluid overload before continuous hemofiltration and survival in critically ill children: a retrospective analysis. Crit Care Med 32(8):1771–1776

    Article  PubMed  Google Scholar 

  30. Friedrich JO, Adhikari N, Herridge MS, Beyene J (2005) Meta-analysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann Intern Med 142(7):510–524

    Article  CAS  PubMed  Google Scholar 

  31. Fulop T, Pathak MB, Schmidt DW, Lengvarszky Z, Juncos JP, Lebrun CJ, Brar H, Juncos LA (2010) Volume-related weight gain and subsequent mortality in acute renal failure patients treated with continuous renal replacement therapy. ASAIO J 56(4):333–337. doi:10.1097/MAT.0b013e3181de35e4

    PubMed Central  PubMed  Google Scholar 

  32. Gadepalli SK, Selewski DT, Drongowski RA, Mychaliska GB (2011) Acute kidney injury in congenital diaphragmatic hernia requiring extracorporeal life support: an insidious problem. J Pediatr Surg 46(4):630–635. doi:10.1016/j.jpedsurg.2010.11.031

    Article  PubMed  Google Scholar 

  33. Gillespie RS, Seidel K, Symons JM (2004) Effect of fluid overload and dose of replacement fluid on survival in hemofiltration. Pediatr Nephrol 19(12):1394–1399. doi:10.1007/s00467-004-1655-1

    Article  PubMed  Google Scholar 

  34. Giuliano RA, Paulus GJ, Verpooten GA, Pattyn VM, Pollet DE, Nouwen EJ, Laurent G, Carlier MB, Maldague P, Tulkens PM et al (1984) Recovery of cortical phospholipidosis and necrosis after acute gentamicin loading in rats. Kidney Int 26(6):838–847

    Article  CAS  PubMed  Google Scholar 

  35. Goldstein SL, Somers MJ, Baum MA, Symons JM, Brophy PD, Blowey D, Bunchman TE, Baker C, Mottes T, McAfee N, Barnett J, Morrison G, Rogers K, Fortenberry JD (2005) Pediatric patients with multi-organ dysfunction syndrome receiving continuous renal replacement therapy. Kidney Int 67(2):653–658. doi:10.1111/j.1523-1755.2005.67121.x

    Article  PubMed  Google Scholar 

  36. Gupta BD, Sharma P, Bagla J, Parakh M, Soni JP (2005) Renal failure in asphyxiated neonates. Indian Pediatr 42(9):928–934

    CAS  PubMed  Google Scholar 

  37. Hall IE, Koyner JL, Doshi MD, Marcus RJ, Parikh CR (2011) Urine cystatin C as a biomarker of proximal tubular function immediately after kidney transplantation. Am J Nephrol 33(5):407–413. doi:10.1159/000326753. 000326753 [pii]

    Google Scholar 

  38. Hayes LW, Oster RA, Tofil NM, Tolwani AJ (2009) Outcomes of critically ill children requiring continuous renal replacement therapy. J Crit Care 24(3):394–400. doi:10.1016/j.jcrc.2008.12.017

    Article  PubMed  Google Scholar 

  39. Heung M, Wolfgram DF, Kommareddi M, Hu Y, Song PX, Ojo AO (2012) Fluid overload at initiation of renal replacement therapy is associated with lack of renal recovery in patients with acute kidney injury. Nephrol Dial Transplant 27(3):956–961. doi:10.1093/ndt/gfr470

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  40. Hoste EA, Clermont G, Kersten A, Venkataraman R, Angus DC, De Bacquer D, Kellum JA (2006) RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care 10(3):R73

    Article  PubMed Central  PubMed  Google Scholar 

  41. Hui-Stickle S, Brewer ED, Goldstein SL (2005) Pediatric ARF epidemiology at a tertiary care center from 1999 to 2001. Am J Kidney Dis 45(1):96–101

    Article  PubMed  Google Scholar 

  42. Izzedine H, Launay-Vacher V, Deray G (2005) Antiviral drug-induced nephrotoxicity. Am J Kidney Dis 45(5):804–817

    Article  CAS  PubMed  Google Scholar 

  43. Karlowicz MG, Adelman RD (1992) Acute renal failure in the neonate. Clin Perinatol 19(1):139–158

    CAS  PubMed  Google Scholar 

  44. Karlowicz MG, Adelman RD (1995) Nonoliguric and oliguric acute renal failure in asphyxiated term neonates. Pediatr Nephrol 9(6):718–722

    Article  CAS  PubMed  Google Scholar 

  45. Kaur S, Jain S, Saha A, Chawla D, Parmar VR, Basu S, Kaur J (2011) Evaluation of glomerular and tubular renal function in neonates with birth asphyxia. Ann Trop Paediatr 31(2):129–134. doi:10.1179/146532811X12925735813922

    Article  CAS  PubMed  Google Scholar 

  46. Kellum JA, Angus DC (2002) Patients are dying of acute renal failure. Crit Care Med 30(9):2156–2157. doi:10.1097/01.CCM.0000026731.62424.B3

    Article  PubMed  Google Scholar 

  47. Koralkar R, Ambalavanan N, Levitan EB, McGwin G, Goldstein S, Askenazi D (2011) Acute kidney injury reduces survival in very low birth weight infants. Pediatr Res 69(4):354–358. doi:10.1203/PDR.0b013e31820b95ca

    Article  PubMed  Google Scholar 

  48. Krawczeski CD, Woo JG, Wang Y, Bennett MR, Ma Q, Devarajan P (2011) Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass. J Pediatr 158(6):1009–1015 e1001. doi:10.1016/j.jpeds.2010.12.057

    Google Scholar 

  49. Lavery AP, Meinzen-Derr JK, Anderson E, Ma Q, Bennett MR, Devarajan P, Schibler KR (2008) Urinary NGAL in premature infants. Pediatr Res 64(4):423–428. doi:10.1203/PDR.0b013e318181b3b2

    Article  CAS  PubMed  Google Scholar 

  50. Li X, Hassoun HT, Santora R, Rabb H (2009) Organ crosstalk: the role of the kidney. Curr Opin Crit Care 15(6):481–487. doi:10.1097/MCC.0b013e328332f69e

    Article  PubMed  Google Scholar 

  51. Luciani GB, Nichani S, Chang AC, Wells WJ, Newth CJ, Starnes VA (1997) Continuous versus intermittent furosemide infusion in critically ill infants after open heart operations. Ann Thorac Surg 64(4):1133–1139

    Article  CAS  PubMed  Google Scholar 

  52. Macedo E, Castro I, Yu L, Abdulkader RR, Vieira JM, Jr. (2008) Impact of mild acute kidney injury (AKI) on outcome after open repair of aortic aneurysms. Ren Fail 30(3):287–296. doi:10.1080/08860220701857522. 791578002 [pii]

    Google Scholar 

  53. Marik PE (2002) Low-dose dopamine: a systematic review. Intensive Care Med 28(7):877–883

    Article  CAS  PubMed  Google Scholar 

  54. Mathur NB, Agarwal HS, and Maria A (2006) Acute renal failure in neonatal sepsis. Indian J Pediatrics 73(6):499–502

    Article  CAS  Google Scholar 

  55. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A, Acute Kidney Injury Network (2007) Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11(2):R31. doi:10.1186/cc5713

    Article  PubMed Central  PubMed  Google Scholar 

  56. Meyer RJ, Brophy PD, Bunchman TE, Annich GM, Maxvold NJ, Mottes TA, Custer JR (2001) Survival and renal function in pediatric patients following extracorporeal life support with hemofiltration. Pediatr Crit Care Med 2(3):238–242

    Article  PubMed  Google Scholar 

  57. Moffett BS, Mott AR, Nelson DP, Goldstein SL, Jefferies JL (2008) Renal effects of fenoldopam in critically ill pediatric patients: a retrospective review. Pediatr Crit Care Med 9(4):403–406

    Article  PubMed  Google Scholar 

  58. Moghal NE, Brocklebank JT, Meadow SR (1998) A review of acute renal failure in children: incidence, etiology and outcome. Clin Nephrol 49(2):91–95

    CAS  PubMed  Google Scholar 

  59. National Heart Lungs, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network, Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, deBoisblanc B, Connors AF Jr, Hite RD, Harabin AL (2006) Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 354(24):2564–2575. doi:10.1056/NEJMoa062200

    Article  Google Scholar 

  60. Nguyen MT, Dent CL, Ross GF, Harris N, Manning PB, Mitsnefes MM, Devarajan P (2008) Urinary aprotinin as a predictor of acute kidney injury after cardiac surgery in children receiving aprotinin therapy. Pediatr Nephrol 23(8):1317–1326. doi:10.1007/s00467-008-0827-9

    Article  PubMed  Google Scholar 

  61. Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim RW, Koyner JL, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD (2011) Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephrol 22(9):1737–1747. doi:10.1681/ASN.2010111163. ASN.2010111163 [pii]

    Google Scholar 

  62. Peruzzi L, Gianoglio B, Porcellini MG, Coppo R (1999) Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase-type-1 selective inhibitor nimesulide as tocolytic. Lancet 354(9190):1615

    Article  CAS  PubMed  Google Scholar 

  63. Picca S, Principato F, Mazzera E, Corona R, Ferrigno L, Marcelletti C, Rizzoni G (1995) Risks of acute renal failure after cardiopulmonary bypass surgery in children: a retrospective 10-year case-control study. Nephrol Dial Transplant 10(5):630–636

    CAS  PubMed  Google Scholar 

  64. Portilla D, Dent C, Sugaya T, Nagothu KK, Kundi I, Moore P, Noiri E, Devarajan P (2008) Liver fatty acid-binding protein as a biomarker of acute kidney injury after cardiac surgery. Kidney Int 73(4):465–472. doi:10.1038/sj.ki.5002721. 5002721 [pii]

    Google Scholar 

  65. Ramesh G, Krawczeski CD, Woo JG, Wang Y, Devarajan P (2010) Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery. Clin J Am Soc Nephrol 5(3):395–401. doi:10.2215/CJN.05140709. CJN.05140709 [pii]

    Google Scholar 

  66. Ricci Z, Cruz D, Ronco C (2008a) The RIFLE criteria and mortality in acute kidney injury: a systematic review. Kidney Int 73(5):538–546. doi:10.1038/sj.ki.5002743. 5002743 [pii]

    Google Scholar 

  67. Ricci Z, Luciano R, Favia I, Garisto C, Muraca M, Morelli S, Di Chiara L, Cogo P, Picardo S (2011) High-dose fenoldopam reduces postoperative neutrophil gelatinase-associated lipocaline and cystatin C levels in pediatric cardiac surgery. Crit Care 15(3):R160. doi:10.1186/cc10295

    Article  PubMed Central  PubMed  Google Scholar 

  68. Ricci Z, Stazi GV, Di Chiara L, Morelli S, Vitale V, Giorni C, Ronco C, Picardo S (2008) Fenoldopam in newborn patients undergoing cardiopulmonary bypass: controlled clinical trial. Interact Cardiovasc Thorac Surg 7(6):1049–1053. doi:10.1510/icvts.2008.185025

    Article  PubMed  Google Scholar 

  69. Ronco C, Davenport A, Gura V (2011) The future of the artificial kidney: moving towards wearable and miniaturized devices. Nefrologia 31(1):9–16. doi:10.3265/Nefrologia.pre2010.Nov.10758

    CAS  PubMed  Google Scholar 

  70. Sakr Y, Vincent JL, Reinhart K, Groeneveld J, Michalopoulos A, Sprung CL, Artigas A, Ranieri VM, Sepsis Occurrence in Acutely Ill Patients Investigator (2005) High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest 128(5):3098–3108. doi:10.1378/chest.128.5.3098

    Article  PubMed  Google Scholar 

  71. Sell LL, Cullen ML, Whittlesey GC, Lerner GR, Klein MD (1987) Experience with renal failure during extracorporeal membrane oxygenation: treatment with continuous hemofiltration. J Pediatr Surg 22(7):600–602

    Article  CAS  PubMed  Google Scholar 

  72. Seri I (1995) Cardiovascular, renal, and endocrine actions of dopamine in neonates and children. J Pediatr 126(3):333–344

    Article  CAS  PubMed  Google Scholar 

  73. Seri I, Abbasi S, Wood DC, Gerdes JS (1998) Regional hemodynamic effects of dopamine in the sick preterm neonate. J Pediatr 133(6):728–734

    Article  CAS  PubMed  Google Scholar 

  74. Seri I, Abbasi S, Wood DC, Gerdes JS (2002) Regional hemodynamic effects of dopamine in the indomethacin-treated preterm infant. J Perinatol 22(4):300–305

    Article  PubMed  Google Scholar 

  75. Shaheen IS, Harvey B, Watson AR, Pandya HC, Mayer A, Thomas D (2007) Continuous venovenous hemofiltration with or without extracorporeal membrane oxygenation in children. Pediatr Crit Care Med 8(4):362–365

    Article  PubMed  Google Scholar 

  76. Sorof JM, Stromberg D, Brewer ED, Feltes TF, Fraser CD Jr (1999) Early initiation of peritoneal dialysis after surgical repair of congenital heart disease. Pediatr Nephrol 13(8):641–645

    Article  CAS  PubMed  Google Scholar 

  77. Sutherland SM, Zappitelli M, Alexander SR, Chua AN, Brophy PD, Bunchman TE, Hackbarth R, Somers MJ, Baum M, Symons JM, Flores FX, Benfield M, Askenazi D, Chand D, Fortenberry JD, Mahan JD, McBryde K, Blowey D, Goldstein SL (2010) Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry. Am J Kidney Dis 55(2):316–325. doi:10.1053/j.ajkd.2009.10.048

    Article  PubMed  Google Scholar 

  78. Sutton TA, Fisher CJ, Molitoris BA (2002) Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney Int 62(5):1539–1549

    Article  CAS  PubMed  Google Scholar 

  79. Uchino S (2008) Outcome prediction for patients with acute kidney injury. Nephron Clin Pract 109(4):c217–223. doi:10.1159/000142931. 000142931 [pii]

    Google Scholar 

  80. Upadya A, Tilluckdharry L, Muralidharan V, Amoateng-Adjepong Y, Manthous CA (2005) Fluid balance and weaning outcomes. Intensive Care Med 31(12):1643–1647. doi:10.1007/s00134-005-2801-3

    Article  PubMed  Google Scholar 

  81. Vachvanichsanong P, Dissaneewate P, Lim A, McNeil E (2006) Childhood acute renal failure: 22-year experience in a university hospital in southern Thailand. Pediatrics 118(3):e786–791. doi:10.1542/peds.2006-0557

    Article  PubMed  Google Scholar 

  82. Walters S, Porter C, Brophy PD (2009) Dialysis and pediatric acute kidney injury: choice of renal support modality. Pediatr Nephrol 24(1):37–48. doi:10.1007/s00467-008-0826-x

    Article  PubMed Central  PubMed  Google Scholar 

  83. Weber TR, Connors RH, Tracy TF Jr, Bailey PV, Stephens C, Keenan W (1990) Prognostic determinants in extracorporeal membrane oxygenation for respiratory failure in newborns. Ann Thorac Surg 50(5):720–723

    Article  CAS  PubMed  Google Scholar 

  84. Williams DM, Sreedhar SS, Mickell JJ, Chan JC (2002) Acute kidney failure: a pediatric experience over 20 years. Arch Pediatr Adolesc Med 156(9):893–900

    Article  PubMed  Google Scholar 

  85. Yoder SE, Yoder BA (2009) An evaluation of off-label fenoldopam use in the neonatal intensive care unit. Am J Perinatol 26(10):745–750

    Article  PubMed  Google Scholar 

  86. Zappitelli M, Krawczeski CD, Devarajan P, Wang Z, Sint K, Thiessen-Philbrook H, Li S, Bennett MR, Ma Q, Shlipak MG, Garg AX, Parikh CR (2011) Early postoperative serum cystatin C predicts severe acute kidney injury following pediatric cardiac surgery. Kidney Int 80(6):655–662. doi:10.1038/ki.2011.123ki2011123 [pii]

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  87. Zappitelli M, Parikh CR, Akcan-Arikan A, Washburn KK, Moffett BS, Goldstein SL (2008) Ascertainment and epidemiology of acute kidney injury varies with definition interpretation. Clin J Am Soc Nephrol 3(4):948–954. doi:10.2215/CJN.05431207. CJN.05431207 [pii]

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Nephrology, Dialysis and Transplantation, Department of Pediatrics, University of Iowa Children’s Hospital, 200 Hawkins Drive, 4035 BT, Iowa City, IA, 52242-1083, USA

    Jennifer G. Jetton MD

  2. Division of Pediatric Nephrology, University of Alabama at Birmingham, 1600 7th Ave South ACC 516, Birmingham, AL, USA

    David Askenazi MD, MsPH

Authors
  1. Jennifer G. Jetton MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David Askenazi MD, MsPH
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jennifer G. Jetton MD .

Editor information

Editors and Affiliations

  1. Division of Pediatric Nephrology, Hypertension and Renal Transplantation, Kentucky Children’s Hospital, University of Kentucky, Lexington, Kentucky, USA

    Aftab S. Chishti

  2. Urogenital Center, Division of Pediatric Urology, Cincinnati Children’s Medical Center, Cincinnati, Ohio, USA

    Shumyle Alam

  3. Division of Pediatrics, University of Kentucky Children's Hospital, Lexington, Kentucky, USA

    Stefan G. Kiessling

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Jetton, J.G., Askenazi, D. (2014). Acute Kidney Injury in the Newborn. In: Chishti, A., Alam, S., Kiessling, S. (eds) Kidney and Urinary Tract Diseases in the Newborn. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39988-6_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-39988-6_16

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-39987-9

  • Online ISBN: 978-3-642-39988-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation