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Adipogenesis Using Human Adipose Tissue-Derived Cells Impregnated with Basic Fibroblast Growth Factor

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Stem Cells in Aesthetic Procedures

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Abstract

Mastectomy results in the loss of one or both breasts and often causes low self-esteem, poor body image, and mental anguish for patients. Recently, tissue engineering has gained favor as an emerging biomedical technology to repair or regenerate lost breast tissues by combining cells with artificial material of cell scaffoldings and growth factor. This chapter focuses on adipogenesis using human adipose tissue-derived cells impregnated with basic fibroblast growth factor (bFGF). bFGF is a key factor present in native adipose tissue. It has been widely utilized in adipose tissue engineering strategies. The use of controlled release of bFGF from various materials has achieved accelerated neovascularization and adipose tissue formation. This strategy has tremendous potential in adipose tissue engineering. Future work is required to perfect this technology for reconstruction of volume contour deformities in adipose tissue due to trauma or surgical interventions.

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Authors and Affiliations

  1. Department of Plastic Surgery, MD Anderson Cancer Center, The University of Texas, 1400 Pressler, Unit 1488, Houston, TX, 77030, USA

    Ran Ito M.D, PhD.

  2. Department of Plastic and Reconstructive Surgery, Kyoto University, 54 Kawahara-cho, Syogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Ran Ito M.D, PhD.

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  1. Ran Ito M.D, PhD.
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Correspondence to Ran Ito M.D, PhD. .

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Editors and Affiliations

  1. Section of Surgery, Newport Specialty Hospital, Tustin, California, USA

    Melvin A. Shiffman

  2. Department of Plastic and Reconstructive Surgery, Marche Polytechnic University Medical School, University of Ancona, Ancona, Italy

    Alberto Di Giuseppe

  3. Department of Plastic Surgery, University of Padova, Padova, Italy

    Franco Bassetto

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Ito, R. (2014). Adipogenesis Using Human Adipose Tissue-Derived Cells Impregnated with Basic Fibroblast Growth Factor. In: Shiffman, M., Di Giuseppe, A., Bassetto, F. (eds) Stem Cells in Aesthetic Procedures. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45207-9_7

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