Skip to main content
SpringerLink
Log in

Prostatic Heat Treatments

  • Chapter
Alternate Methods in the Treatment of Benign Prostatic Hyperplasia

  • 61 Accesses

Abstract

One of the new treatment regimes available for symptomatic benign prostatic hyperplasia (BPH) involves heating the prostate. This rapidly evolving technique aims to provide relief to obstructed patients in an outpatient setting with minimal anesthesia. The term “hyperthermia” has become associated with the current trend for heat treatment of the prostate, but it has its origin in the treatment of malignant tissue. Indeed, the initial experience with transrectal microwave probes was gained in treating prostatic cancer. An applicator containing a microwave antenna was developed which could be placed into the rectum and aimed at the prostate. This energy delivery system allowed controlled heating of the prostate to specific temperatures within a confined space. The treatments for prostatic cancer were based on the observation that malignant tissue, but not normal tissue, was susceptible to temperatures of 42°–43.5°C. This temperature range has been adopted by some of the current devices to treat BPH, and the use of the term “hyperthermia” is thus restricted to define those treatments which developed directly from cancer therapy and which heat to <44°C. Hyperthermia treatments for BPH are delivered by microwave antennae placed in the rectum and do not cause tissue necrosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Astrahan MA, Sapozink MD, Cohen D, Luxton G, Kampp TD, Boyd S, Petrovich Z (1989) Microwave applicator for transurethral hyperthermia of benign prostatic hyperplasia. Int J Hyperthermia 5:283–296

    Article  PubMed  CAS  Google Scholar 

  • Astrahan MA, Ameye F, Oyen R, Willeman P, Baert L, Petrovich Z (1991) Interstitial temperature measurements during transurethral microwave hyperthermia. J Urol 145:304–308

    PubMed  CAS  Google Scholar 

  • Baert L, Ameye F, Willemen P, Vandenhove J, Lauweryns J, Astrahan M, Petrovich Z (1990) Transurethral microwave hyperthermia for benign prostatic hyperplasia: preliminary clinical and pathological results. J Urol 144:1383–1387

    PubMed  CAS  Google Scholar 

  • Baert L, Willeman P, Ameye F, Petrovich Z (1991) Treatment response with transurethral microwave hyperthermia in different froms of bening prostatic hyperplasia: a preliminary report. Prostate 18:315–320

    Article  PubMed  CAS  Google Scholar 

  • Barnes DG, Perlmutter AP, Watson GM (1991) Transrectal hyperthermia in the benign painful prostate. World J Urol 9:12–14

    Article  Google Scholar 

  • Bosch RJLH, Griffiths DJ, Blom JHM, Schroeder FH. (1989) Treatment of benign prostatic hyperplasia by androgen deprivation: effects on prostate size and urodynamic parameters. J Urol 141:68

    PubMed  CAS  Google Scholar 

  • Boyarsky S, Jones G, Paulson DF, Prout GR (1977) A new look at bladder neck obstruction by the Food and Drug Administration regulators: guidelines for investigation of benign prostatic hypertrophy. Trans Am Assoc Genito Urinary Surg 68:29–32

    Google Scholar 

  • Bruskewitz RC, Larsen EH, Madsen PO, Dorflinger T (1986) Three year follow-up of urinary symptoms after transurethral resection of the prostate. J Urol 136:613

    PubMed  CAS  Google Scholar 

  • Busch W (1866) Über den Einfluss, welchen heftigere Erysipeln zuweilen auf organisierte Neubildungen ausüben. Verhandl Naturh Preus, Rhein Westphal 23:28

    Google Scholar 

  • Caine M, Perlberg S, Meretyk S (1978) A placebo-controlled double-blind study of the effect of phenoxybenzamine in benign prostatic obstruction. Br J Urol 50:551

    Article  PubMed  CAS  Google Scholar 

  • Carter SSC, Patel A, Reddy P, Royer P, Ramsay JWA (1991) Single-session transurethral microwave thermotherapy for the treatment of benign prostatic obstruction. J Endourol 5:137–144

    Article  Google Scholar 

  • Castaneda F, Banno J, Brady T (1991) Experimental prostatic hyperthermia. J Endourol 5:123–127

    Article  Google Scholar 

  • Devonec M, Berger N, Perrin P (1991) Transurethral microwave heating of the prostate-or from hyperthermia to thermotherapy. J Endourol 5:129–135

    Article  Google Scholar 

  • Harada T, Etori K, Kumazaki T, Nishizawa O, Noto H, Tsuchda S (1985) Microwave surgical treatment of diseases of the prostate. Urology 26:572–576

    Article  PubMed  CAS  Google Scholar 

  • Harada T, Tsuchida S, Nishizana O et al. (1987) Microwave surgical treatment of the prostate: clinical application of microwave surgery as a tool for improved prostatic electroresection. Urol Int 42:127–131

    Article  PubMed  CAS  Google Scholar 

  • Issacs JT (1990) Importance of the natural history of benign prostatic hyperplasia in the evaluation of pharmacologic intervention. Prostate Suppl 3:1–7

    Article  Google Scholar 

  • Katzir A, Bowman HF, Asfour Y, Zur A, Valeri CR (1989) Infared fibers for radiometer themometry in hypothermia and hyperthermia treatment. Trans Biomed Eng 36:634–637

    Article  CAS  Google Scholar 

  • Lieb Z, Rothem A, Lev A, Servadio C (1986) Histopatholocal observations in the canine prostate treated by local microwave hyperthermia. Prostate 8:93–102

    Article  Google Scholar 

  • Lieb, Z, Lev A, Goren E, Servadio C (1991a) Observations on the influence of syproterone acetate on the sonographic image of the begin prostate in patients treated with local hyperthermia. World J Urol 9:19–21

    Google Scholar 

  • Lieb Z, Lev A, Servadio C (1991b) Transrectal ultrasound in local hyperthermia to the benign prostate. World J Urol 9:15–18

    Google Scholar 

  • Lindner A, Golomb J, Siegel Y, Lev A (1987) Local hyperthermia of the prostate gland for the treatment of benign prostatic hypertrophy and urinary retention: a preliminary report. Br J Urol 60:567–571

    Article  PubMed  CAS  Google Scholar 

  • Lindner A, Braf Z, Lev A, Golumb J, Leib Y, Siegel Y, Servadio C (1990a) Local hyperthermia of the prostate gland for the treatment of benign prostatic hypertrophy and urinary retention. Br J Urol 65:201–203

    Article  PubMed  CAS  Google Scholar 

  • Lindner A, Siegel R, Saranga R, Korzcak D, Matzkin H, Braf Z (1990b) Complications in hyperthermia treatment of benign prostatic hyperplasia. J Urol 144:1390–1392

    PubMed  CAS  Google Scholar 

  • Lindner A, Siegel YI, Korczak D (1990c) Serum prostatic specific antigen levels during hyperthermia treatment of benign prostatic hyperplasia. J Urol 144:1388–1389

    PubMed  CAS  Google Scholar 

  • Madsen OM Iverson P (1983) A point system for selecting operative candidates. In: Hinman F Jr (ed) Benign Prostatic Hypertrophy. Springer, Berlin Heidelberg New York, p 763

    Chapter  Google Scholar 

  • Magin RL, Fridd CW, Bonfiglio TA Linke CA (1980) Thermal destruction of the canine prostate by high intensity microwaves. J Surg Res 29:265–275

    Article  PubMed  CAS  Google Scholar 

  • Matsuda H, Sugimachi K, Kuwano H, Mori M (1989) Hyperthermia, tissue microcirculation, and temporarily increased thermosensitivity in VX2 carcinoma in rabbit liver. Cancer Res 49:2777–2782

    PubMed  CAS  Google Scholar 

  • Meshorer A (1990) Treatment of BPH using the Thermex-II. Abstracts Eur Assoc Urol IX Congr 18 [Suppl 1]:264

    Google Scholar 

  • Meyhoff H-H (1987) Transurethral versus transvesical prostatectomy: clinical, urodynamic, renographic, and economic aspects a randomized study. Scand J Nephrol [Suppl] 102:1–26

    CAS  Google Scholar 

  • MK-906 (Finasteride) Study Group (1991) One-year experience in the treatment of benign prostatic hyperplasia with finasteride. J Androl 12:372–375

    Google Scholar 

  • Newman D, Knapp P (1990) Interstitial temperature mapping in human prostate during transrectal hyperthermia treatment for BPH. J Endourol 4:S135

    Article  Google Scholar 

  • Nishimura Y, Jo S, Akuta K, Masunaga S, Fushiki M, Hiraoka M, Takahashi M, Abe M (1989) Histological analysis of the effect of hyperthermia on normal rat hepatic vasculature. Cancer Res 49:4295–4297

    PubMed  CAS  Google Scholar 

  • Osterling JE (1991) The origin and development of benign prostatic hyperplasia: and age dependent process. J Androl 12:348–355

    Google Scholar 

  • Paliwal BR, Shrivastava PN (1989) Microwave hyperthermia: principles and quality assurance. Radiol Clin North Am 27:489–497

    PubMed  CAS  Google Scholar 

  • Perez-Castro E, Carbonero M, Mancebo JM, Massarra J, Iglesias JI (1991) Tratamiento de la hipertrofia benigna prostatica (HPB) con termoterapia transurettal. Experiencia inicial. Arch Esp Urol 44.5:637–645

    CAS  Google Scholar 

  • Resnick MI, Jackson JE, Watts LE, Boyce WH (1983) Assessment of the antihypercholesterolemic drug, probucol, in benign prostatic hyperplasia. J Urol 129:206–209

    PubMed  CAS  Google Scholar 

  • Rigatti P, Buonaguidi A, Grasso M, Lania C, Montorsi F, Colombo R, Galli L, Guazzoni G. (1990) Morphometric and biochemical assessment of seminal plasma in patients who underwent local prostatic hyperthermia. Prostate 16:325–330

    Article  PubMed  CAS  Google Scholar 

  • Sapareto SA, Dewy WC (1984) Thermal dose determination in cancer therapy. J Radiat Oncol Biol Phys 10:787–800

    Article  CAS  Google Scholar 

  • Sapozink MD, Boyd SD, Astrahan MA, Jozsef G, Petrovich Z. (1990) Transurethral hyperthermia for benign prostatic hyperplasia: preliminary clinical results. J Urol 113:944–950

    Google Scholar 

  • Saranga R, Matzkin H, Braf Z (1990) Local microwave hyperthermia in the treatment of benign prostatic hyperplasia. Br J Urol 65:349–353

    Article  PubMed  CAS  Google Scholar 

  • Servadio C, Leib Z, (1984) Hyperthermia in the treatment of prostate cancer. Prostate 5:205–211

    Article  PubMed  CAS  Google Scholar 

  • Servadio C, Lieb Z, Lev A (1986) Further observations on the use of local hyperthermia for the treatment of diseases of the prostate in man. Eur J Urol 12:38–40

    CAS  Google Scholar 

  • Servadio C, Leib Z, Lev A (1987) Diseases of prostate treated by local microwave hyperthermia. Urology 30:97–99

    Article  PubMed  CAS  Google Scholar 

  • Servadio C, Linder A, Lev A, Leib Z, Siegel Y, Braf Z (1989) Further observations on the effect of local hyperthermia on benign enlargement of the prostate. World J Urol 6:204–208

    Article  Google Scholar 

  • Servadio C, Braf Z, Siegel Y, Leib Z, Saranga R, Lindner A. (1990) Local thermotherapy of the benign prostate: a 1-year follow-up. Eur Urol 18:169–173

    PubMed  CAS  Google Scholar 

  • Siroky MB (1990) Interpretation of urinary flow rates. Urol Clin North Am 17:537–542

    PubMed  CAS  Google Scholar 

  • Siroky MB, Olsson C, Krane RJ (1979) The flow rate nomogram: I. Development. J Urol 122:665–668

    PubMed  CAS  Google Scholar 

  • Song CW (1978) Effect of hyperthermia on vascular functions of normal tissues and experimental tumours. JNCI 60:711–713

    PubMed  CAS  Google Scholar 

  • Stawarz B, Szmiglielski S, Orgrodnik J, Astrahan M, Petrovich Z (1991) A comparison of transurethral and transrectal microwave hyperthermia in poor risk surgical benign prostatic hypertrophy patients. J Urol 146:353–357

    PubMed  CAS  Google Scholar 

  • Strohmaier WL, Bichler KH, Fluchter SH, Wilbert DM (1990) Local microwave hyperthermia of benign prostatic hyperplasia. J Urol 144:913–917

    PubMed  CAS  Google Scholar 

  • Van den Bossche M, Noel JC, Schulman CC (1991) Transurethral hyperthermia for benign prostatic hypertrophy. World J Urol 9:2–6

    Article  Google Scholar 

  • Van Erps P, Dourcy B, Denis LJ (1990) Transrectal hyperthermia in benign prostatic hyperplasia (BPH. Abstr Eur Assoc Urol IX Congr 18 [Suppl l]:510

    Google Scholar 

  • Watson GM, Perlmutter AP, Shah TK, Barnes DG (1991) Heat treatment for severe, symptomatic prostatic outflow obstruction. World J Urol 9:7–11

    Article  Google Scholar 

  • Yerushalmi A (1975) Cure of a solid tumor by simultaneous administration of microwaves and x-ray irradiation. Radiat Res 64:602

    Article  PubMed  CAS  Google Scholar 

  • Yerushalmi A, Servadio C, Leib Z, Fishelovitz Y, Rokowsky E, Stein JA (1982) Local hyperthermia for treatment of carcinoma of the prostate: a preliminary report. Prostate 3:623–630

    Article  PubMed  CAS  Google Scholar 

  • Yerushalmi A, Fishelovitz Y, Singer D, Reiner I, Arielly J, Abramovici Y, Catsenelson R, Levy E, Shani A (1985) Localized deep microwave hyperthermia in the treatment of poor operative risk patients with benign prostatic hyperplasia. J Urol 133:873–876

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. A. P. Perlmutter
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Urology, St. Luke’s/Roosevelt Hospital Center, 428 West 59th Street, New York, New York, 10019, USA

    Nicholas A. Romas M.D.

  2. New York Hospital-Cornell Medical Center, 525 East 68th Street, New York, New York, 10021, USA

    E. Darracott Vaughan M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Perlmutter, A.P. (1993). Prostatic Heat Treatments. In: Romas, N.A., Vaughan, E.D. (eds) Alternate Methods in the Treatment of Benign Prostatic Hyperplasia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45723-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-45723-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45725-8

  • Online ISBN: 978-3-642-45723-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation