Skip to main content
SpringerLink
Log in

Kinins and Ventilation of the Lungs

  • Chapter
Bradykinin, Kallidin and Kallikrein

Abstract

Kinins influence mammalian lungs both directly and indirectly. In several species, kinins lessen the volume of air entering the lungs during spontaneous or artificial ventilation in vivo and, in the guinea pig, they are also effective in isolated preparations of lungs or tracheobronchial muscle. In some species also, kinins raise the pressure in the pulmonary artery and constrict isolated pulmonary blood vessels. Kinins affect, too, the rate and depth of the ventilatory movements of ribs and diaphragm.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aarsen, P. N.: The influence of analgesic antipyretic drugs on the responses of guinea-pig lungs to bradykinin. Brit. J. Pharmacol. 27, 196–204 (1966).

    CAS  Google Scholar 

  • Abe, K., Watanabe, N., Kuit Gai, N., Mouri, T., Seri, T., Yoshinaga, K.: Cicurlating plasma kinin in patients with bronchial asthma. Experientia (Basel) 23, 626 (1967).

    Article  CAS  Google Scholar 

  • Berry, P. A.: Slow-reacting substance in anaphylaxis (SRS-A), its release, actions and antagonism. Ph.D. Thesis. Council of National Academic Awards, London, p. 91–93 (1966).

    Google Scholar 

  • Berry, P. A. Collier, H. O. J.: Bronchoconstrictor action and antagonism of a slow-reacting substance from anaphylaxis of guinea-pig lung. Brit. J. Pharmacol. 23, 201–216 (1964).

    CAS  Google Scholar 

  • Bhoola, K. D., Collier, H. O. J., Schachter, M., Shorley, P. G.: Action of some peptides on bronchial muscle. Brit. J. Pharmacol. 19, 190–197 (1962).

    CAS  Google Scholar 

  • Bisset, G. W., Lewis, G. P.: A spectrum of pharmacological activity in some biologically active peptides. Brit. J. Pharmacol. 19, 168–182 (1962).

    CAS  Google Scholar 

  • Brocklehurst, W. E., Lahiri, S. C.: The production of bradykinin in anaphylaxis. J. Physiol. (Lond.) 160, 15–16P (1962).

    Google Scholar 

  • Brocklehurst, W. E., Lahiri, S. C.: Formation and destruction of bradykinin during anaphylaxis. J. Physiol. (Lond.) 165, 39–40P (1963).

    Google Scholar 

  • Carpi, A., Klurp, H., Konzett, H.: Über die Bradykinin-Wirkung am Herz-LungenPriiparat des Meerschweinchens. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 243, 356 (1962).

    Google Scholar 

  • Collier, H. O. J.: Some pharmacological correlates of anti-inflammatory activity. A study of nonsteroidal anti-inflammatory drugs as antagonists of local hormones. In: Non-steroidal anti-inflammatory drugs, p. 139–150, ed. by S. Garattini, and N. M. G. DUKES. Amsterdam: Excerpta Medica 1965.

    Google Scholar 

  • Collier, H. O. J.: Self-antagonism of bronchoconstriction induced by bradykinin and angiotensin. In: Hypotensive peptides, p. 305–313, ed. by E. G. Erdös, N. Back, and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Collier, H. O. J.: A pharmacological analysis of aspirin. Advanc. Pharmacol., 7, 333–405 (1969).

    CAS  Google Scholar 

  • Collier, H. O. J., Hammond, A. R., Whiteley, B.: Anti-anaphylactic action of acetylsalicylate in guinea-pig lung. Nature (Lond.) 200, 176–178 (1963).

    Article  CAS  Google Scholar 

  • Collier, H. O. J., Holgate, J. A., Schachter, M., Shorley, P. G.: An apparent bronchoconstrictor action of bradykinin and its suppression by some anti-inflammatory agents. J. Physiol. (Lond.) 149, 54–55P (1959).

    Google Scholar 

  • Collier, H. O. J., Holgate, J. A., The bronchoconstrictor action of bradykinin in the guinea-pig. Brit. J. Pharmacol. 15, 290–297 (1960).

    CAS  Google Scholar 

  • James, G. W. L.: Humoral factors affecting pulmonary inflation during acute anaphylaxis in the guinea-pig. Brit. J. Pharmacol. 30, 283–301 (1967).

    Google Scholar 

  • James, G. W. L.: Humoral factors in airway function, with particular reference to anaphylaxis in the guinea-pig. In: The physiology and pharmacology of the airways, ed. by A. BouuUYs. Springfield, Ill.: Thomas 1969.

    Google Scholar 

  • James, G. W. L., Piper, P. J.: Intensification by adrenalectomy or by ß-adrenergic blockade of the bronchoconstrictor action of bradykinin in the guinea-pig. J. Physiol. (Lond.) 180, 13–14P (1965).

    Google Scholar 

  • James, G. W. L., Piper, P. J.: Antagonism by fenamates and like-acting drugs of bronchoconstriction induced by bradykinin or antigen in the guinea-pig. Brit. J. Pharmacol. 34, 76–87 (1968).

    Google Scholar 

  • James, G. W. L., Piper, P. J., Schneider, C.: Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5’-triphosphate. Nature (Lond.) 212, 411–412 (1966).

    Article  Google Scholar 

  • Shorley, P. G.: Analgesic antipyretic drugs as antagonists of bradykinin. Brit. J. Pharmacol. 15, 601–610 (1960).

    Google Scholar 

  • Shorley, P. G.: Antagonism by mefenamic and flufenamic acids of the bronchoconstrictor action of kinins in the guinea-pig. Brit. J. Pharmacol. 20, 345–351 (1963).

    Google Scholar 

  • Comune, R. S., Silver, M., Sinclair, D. G.: The effects of bradykinin, angiotensin and acetylcholine on the bovine adrenal medulla. J. Physiol. (Lond.) 196, 339–350 (1968).

    Google Scholar 

  • Di Mattel, P.: Occurrence of bradykinin in human pulmonary carcinoma. Biochem. Pharma

    Google Scholar 

  • col. 16 909–911 (1967).

    Google Scholar 

  • Dolovioh, J., Back, N., Arbesman, C. E.: The presence of bradykinin-like activity in nasal secretions from allergic subjects. J. Allergy (Abstr.) 41, 103 (1968).

    Google Scholar 

  • Elliott, D. F., Horton, E. W., Lewis, G. P.: Actions of pure bradykinin. J. Physiol. (Lond.) 153, 473–480 (1960).

    CAS  Google Scholar 

  • Erdös, E. G.: Hypotensive peptides. Bradykinin, kallidin and eledoisin. Advanc. Pharmacol. 4, 1–90 (1966).

    Google Scholar 

  • Feldberg, W., Lewis, G. P.: The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin. J. Physiol. (Lond.) 171, 98–108 (1964).

    CAS  Google Scholar 

  • Ferreira, S. H., Vane, J. R.: The disappearance of bradykinin and eledoisin in the circulation and vascular beds of the cat. Brit. J. Pharmacol. 30, 417–424 (1967).

    Google Scholar 

  • Girard, J. P., Moret, P.: Action de la sérotonine et de la bradykinine en aérosols chezles asthmatiques. Helv. med. Acta 30, 520–526 (1963).

    CAS  Google Scholar 

  • Gaurls, V., Heicke, B., Westermann, E.: Über die Stimulierung der Atmung durch Bradykinin und Kallidin. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 247, 429–444 (1964a).

    Google Scholar 

  • Gaurls, V., Heicke, B., Westermann, E.: Apnoe nach Bradykinin und Kallidin. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 248, 540–551 (1964b).

    Google Scholar 

  • Gaurls, V., Westermann, E.: Bronchoconstrictor action of bradykinin, kallidin and eledoisin. Nature (Lund.) 205, 402–404 (1965).

    Article  Google Scholar 

  • Greeff, K., Moog, E.: Vergleichende Untersuchungen über die bronchoconstrictorische und gefäßconstrictorische Wirkung des Bradykinins, Histamins und Serotonins an isolierten Lungenpräparaten. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 248, 204–215 (1964).

    CAS  Google Scholar 

  • Greeff, K., Scharnagel, K., Lünn, R., Strobach, H.: Die Abnahme des Kininogengehaltes des Plasmas beim toxischen, anaphylaktischen und anaphylaktoiden Schock. Naunyn Schmiedebergs Arch. exp. Path. Pharmak. 253, 235–245 (1966).

    CAS  Google Scholar 

  • Green, M.: How big are the bronchioles ? St Thom. Hosp. Gaz. 63, 136–139 (1966).

    Google Scholar 

  • Hauge, A., Lunde, P. K. M., Waaler, B. A.: The effect of bradykinin, kallidin and eledoisin upon the pulmonary vascular bed of an isolated blood-perfused rabbit lung preparation. Acta physiol. scand. 66, 269–277 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Hawkins, D. F.: Pharmacological studies of bronchial and intestinal muscle in relation to anaphylaxis and asthma. Ph.D. Thesis, University of London, p. 250–251, 367; 1952.

    Google Scholar 

  • Herxheimer, H, Stresemann, E.: The effect of bradykinin aerosol in guinea-pigs and in man. J. Physiol. (Lond.) 158, 38–39P (1961).

    Google Scholar 

  • Herxheimer, H, Stresemann, E.: Bradykinin and ethanol in bronchial asthma. Arch. int. Pharmacodyn. 144, 315–318 (1963).

    CAS  Google Scholar 

  • Janküt., E. O., Virtama P.: Bronchographic demonstration of the bronchoconstrictor

    Google Scholar 

  • effect of bradykinin in the guinea-pig. Ann. Med. exp. Fenn. 41, 436–440 (1963).

    Google Scholar 

  • Jahn, U., Wagner-Jauregg T.: Vergleich von zwei neuen Klassen antiphlogistischer

    Google Scholar 

  • Substanzen im Collier-Test. Arzneimittel-Forsch. 18, 120–121 (1968).

    Google Scholar 

  • James, G. W. L.: The use of the in vivotrachea preparation of the guinea-pig to assessdrug action on lung. J. Pharm. Pharmacol. 21, 379–386 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Jonasson, O., Becker, E. L.: Release of kallikrein from guinea pig lung during anaphylaxis. J. exp. Med. 123, 509–522 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Konzett, H., Rössler, R.: Versuchsanordnung zu Untersuchungen an der Bronchial muskulatur. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 195, 71–74 (1940).

    Google Scholar 

  • Konzett, H., STÜRmer, E.: Biological activity of synthetic polypeptides with bradykinin-like properties. Brit. J. Pharmacol. 15, 544 551 (1960).

    Google Scholar 

  • Lahiri, S C: The activation of kinins by antigen-antibody reactions. Ph.D. Thesis. Edinburgh University, p. 66–87, 1962.

    Google Scholar 

  • Lecomte, J., Petit, J. M., MÉLon, J., Troquet, J., Marcelle, R.: Propriétés bronchoconstrictrices de la bradykinine chez l’homme asthmatique. Arch. int. Pharmacodyn. 137, 232–235 (1962).

    CAS  Google Scholar 

  • Lecomte, J., Troquet, J., Cession-Fosslon, A.: Sur la nature de l’hypertension artérielle provoquée par la bradykinine et la kallidine. Arch. int. Pharmacodyn. 147, 518–524 (1964).

    CAS  Google Scholar 

  • Lecomte, J., Troquet, J., Dresse, A.: Stimulation médullo-surrénalienne par la bradykinine. Arch. int. Physiol. 69, 89–91 (1961).

    CAS  Google Scholar 

  • Lewis, G. P.: Kinin antagonism and kinin formation. In: Salicylates: An International Symposium, p. 134–137, ed. by A. ST. J. Dixon, B. K. Martin, M. J. H. Smith, and P. N. H. Wood. London: Churchill 1963.

    Google Scholar 

  • Lewis, G. P., Reit, E.: The action of angiotensin and bradykinin on the superior cervical ganglion of the cat. J. Physiol. (Lond.) 179, 538–553 (1965).

    CAS  Google Scholar 

  • Lewis, G. P., Reit, E.: Further studies on the actions of peptides on the superior cervical ganglion and suprarenal medulla. Brit. J. Pharmacol. 26, 444 460 (1966).

    Google Scholar 

  • Marquardt, H.: Zur Frage der Entstehung der vagal-reflektorischen Bradykinin-Tachypnoe. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 253, 207–220 (1966).

    CAS  Google Scholar 

  • Moog, E., Greeff, K.: Der Einfluß verschiedener biogener Amine und Polypeptide auf die Gefäß-und Bronchialmuskulatur isoliert durchströmter Meerschweinchenlungen. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 246, 16–17 (1963).

    CAS  Google Scholar 

  • Piper, P. J., Collier, H. O. J., Vane, J. R.: Release of catecholamines in the guinea-pig by substances involved in anaphylaxis. Nature (Lond.) 213, 838–840 (1967).

    Article  CAS  Google Scholar 

  • Piper, P. J., Vane, J. R.: The assay of catecholamines released into the circulation of the guinea-pig by angiotensin. J. Physiol. (Lond.) 188, 20–21P (1967).

    Google Scholar 

  • Rosenthale, M. E., Dexvinis, A., Begany, A. J., Lapidus, M., Gluckman, M. I.: Bronchodilator activity of the prostaglandin PGE2. Pharmacologist 10, 175 (1968).

    Google Scholar 

  • Smixz, J., Graeme, M. L., Sigg, E. B.: Bradykinin induced bronchoconstriction in guinea-pigs and its modification by various agents. Arch. int. Pharmacodyn. 165, 291–301 (1967).

    Google Scholar 

  • Staszewska-Barczak, J., Vane, J. R.: The release of catecholamines from the adrenal medulla by peptides. Brit. J. Pharmacol. 30, 655–667 (1967).

    CAS  Google Scholar 

  • Stresemann, E.: Die Wirkung von Bradykinin-Aerosol auf die Atmung des Menschen und des Meerschweinchens und der Einfluß verschiedener Substanzen auf den experimentellen Bradykinin-Bronchospasmus. Acta allerg. (Kbh.) 18, 235–255 (1963).

    CAS  Google Scholar 

  • Stürmer, E., Berde, B.: A comparative pharmacological study of synthetic eledoisin and synthetic bradykinin J Pharmacol. exp. Ther. 140, 349–355 (1963).

    PubMed  Google Scholar 

  • Trendelenburg, U.: Observations on the ganglion-stimulating action of angiotensin and bradykinin J Pharmacol. exp. Ther. 154, 418–425 (1966).

    PubMed  CAS  Google Scholar 

  • Varonier, H. S., Panzani, R.: The effect of inhalation of bradykinin on healthy and atopic (asthmatic) children. Int. Arch. Allergy 34, 293–296 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Waaler, B. A.: The effect of bradykinin in an isolated perfused dog lung preparation. J. Physiol. (Lond.) 157, 475–483 (1961).

    CAS  Google Scholar 

  • Weibel, E. R.: Morphometry of the human lung, p. 110–143. Berlin-Göttingen-Heidelberg: Springer 1963.

    Google Scholar 

  • Widdicombe, J. G.: Regulation of tracheobronchial smooth muscle. Physiol. Rev. 43, 1–37 (1963).

    CAS  Google Scholar 

Download references

Authors
  1. H. O. J. Collier
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Oklahoma Medical Center, Oklahoma City, Oklahoma, USA

    Ervin G. Erdös

Rights and permissions

Reprints and permissions

Copyright information

© 1970 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Collier, H.O.J. (1970). Kinins and Ventilation of the Lungs. In: Erdös, E.G., Wilde, A.F. (eds) Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 25 / 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46222-1_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-46222-1_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46224-5

  • Online ISBN: 978-3-642-46222-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation