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Anaesthetic Considerations

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Palliative Surgery

Abstract

The provision of high-quality surgical palliative care requires a coordinated team approach, and in this context anaesthetists are valuable members of the perioperative palliative care team. In particular, the relief of suffering and distressing symptoms has been a core component of anaesthesia practice since its inception. Anaesthetists possess valuable skills important to the provision of perioperative care for patients undergoing palliative surgery. These include the ability to provide effective analgesia; to relieve symptoms of nausea, anxiety, and dyspnoea; and to stabilize perioperative physiological derangements in this vulnerable patient population. This chapter will review the core principles underlying effective perioperative management for patients undergoing palliative surgical procedures, with a focus on perioperative pathophysiological considerations, effective intraoperative management and perioperative symptom control.

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References

  1. World Health Organization. Palliative care. Switzerland: World Health Organization; 2007.

    Google Scholar 

  2. American College of Surgeons Committee on Ethics and Surgical Palliative Care Task Force. Statement of principles of palliative care. Bull Am Coll Surg. 2005;90(8):34–5.

    Google Scholar 

  3. Dunn GP. Surgical palliative care: recent trends and developments. Anesthesiol Clin. 2012;30(1):13–28.

    Article  PubMed  Google Scholar 

  4. Miner TJ, Brennan MF, Jaques DP. A prospective, symptom related, outcomes analysis of 1022 palliative procedures for advanced cancer. Ann Surg. 2004;240(4):719–26.

    PubMed Central  PubMed  Google Scholar 

  5. Miner TJ. Communication as a core skill of palliative surgical care. Anesthesiol Clin. 2012;30(1):47–58.

    Article  PubMed  Google Scholar 

  6. McCahill LE, Krouse R, Chu D, Juarez G, Uman GC, Ferrell B, et al. Indications and use of palliative surgery – results of Society of Surgical Survey. Ann Surg Oncol. 2002;9(1):104–12.

    Article  PubMed  Google Scholar 

  7. Krouse RS, Nelson RA, Farrell BR, Grube B, Juarez G, Wagman LD, et al. Surgical palliation at a cancer center: incidence and outcomes. Arch Surg. 2001;136(7):773–8.

    Article  CAS  PubMed  Google Scholar 

  8. Solano JP, Gomes B, Higginson IJ. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manage. 2006;31(1):58–69.

    Article  PubMed  Google Scholar 

  9. Cady B, Easson A, Aboulafia AJ, Ferson PF. Part 1: surgical palliation of advanced illness–what’s new, what’s helpful. J Am Coll Surg. 2005;200(1):115–27.

    Article  PubMed  Google Scholar 

  10. Workgroup SPC. Office of promoting excellence in end-of-life care: Surgeon’s Palliative Care Workgroup report from the field. J Am Coll Surg. 2003;197(4):661–86.

    Article  Google Scholar 

  11. Dunn GP. Palliative surgical outcomes: are we looking through a keyhole? Ann Surg Oncol. 2012;19(12):3637–8.

    Article  PubMed  Google Scholar 

  12. Tseng WH, Yang X, Wang H, Martinez SR, Chen SL, Meyers FJ, et al. Nomogram to predict risk of 30-day morbidity and mortality for patients with disseminated malignancy undergoing surgical intervention. Ann Surg. 2011;254(2):333–8.

    Article  PubMed  Google Scholar 

  13. McCahill LE, Smith DD, Borneman T, Juarez G, Cullinane C, Chu DZ, et al. A prospective evaluation of palliative outcomes for surgery of advanced malignancies. Ann Surg Oncol. 2003;10(6):654–63.

    Article  PubMed  Google Scholar 

  14. Podnos YD, Juarez G, Pameijer C, Choi K, Ferrell BR, Wagman LD. Impact of surgical palliation on quality of life in patients with advanced malignancy: results of the decisions and outcomes in palliative surgery (DOPS) trial. Ann Surg Oncol. 2007;14(2):922–8.

    Article  PubMed  Google Scholar 

  15. Badgwell B, Krouse R, Cormier J, Guevara C, Klimberg VS, Ferrell B. Frequent and early death limits quality of life assessment in patients with advanced malignancies evaluated for palliative surgical intervention. Ann Surg Oncol. 2012;19(12):3651–8.

    Article  PubMed  Google Scholar 

  16. Thomay AA, Jaques DP, Miner TJ. Surgical palliation: getting back to our roots. Surg Clin North Am. 2009;89(1):27–41.

    Article  PubMed  Google Scholar 

  17. Gutt CN, Held S, Paolucci V, Encke A. Experiences with percutaneous endoscopic gastrostomy. World J Surg. 1996;20(8):1106–8.

    Article  Google Scholar 

  18. Young-Spint M, Guner YS, Meyers FJ, Schneider P, Khatri VP. Radical palliative surgery: new limits to pursue. Pediatr Surg Int. 2009;25(10):917–21.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Lee TH, Marcantonio ER, Mangione CM, Thomas EJ, Polanczyk C, Cook EF, et al. Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation. 1999;100:1043–9.

    Article  CAS  PubMed  Google Scholar 

  20. Arozullah AM, Daley J, Henderson WG, Khuri SF. Multifactorial risk index for predicting postoperative respiratory failure in men after major noncardiac surgery. The National Veterans Administration Surgical Quality Improvement Program. Ann Surg. 2000;232(2):242–53.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Canet J, Gallart L, Gomar C, Paluzie G, Vallès J, Castillo J, et al. Prediction of postoperative pulmonary complications in a population-based surgical cohort. Anesthesiology. 2010;113(6):1338–50.

    Article  PubMed  Google Scholar 

  22. el-Ganzouri AR, McCarthy RJ, Tuman KJ, Tanck EN, Ivankovich AD. Preoperative airway assessment: predictive value of a multivariate risk index. Anesth Analg. 1996;82(6):1197–204.

    CAS  PubMed  Google Scholar 

  23. Iseli TA, Iseli CE, Golden JB, Jones VL, Boudreaux AM, Boyce JR, et al. Outcomes of intubation in difficult airways due to head and neck pathology. Ear Nose Throat J. 2012;91(3):E1–5.

    PubMed  Google Scholar 

  24. Shekar K, Foot C, Fraser J, Ziegenfuss M, Hopkins P, Windsor M. Bronchopleural fistula: an update for intensivists. J Crit Care. 2010;25(1):47–55.

    Article  PubMed  Google Scholar 

  25. Konstantinov IE, Saxena P. Independent lung ventilation in the postoperative management of large bronchopleural fistula. J Thorac Cardiovasc Surg. 2010;139(2):e21–2.

    Article  PubMed  Google Scholar 

  26. Reynen K, Köckeritz U, Strasser RH. Metastases to the heart. Ann Oncol. 2004;15(3):375–81.

    Article  CAS  PubMed  Google Scholar 

  27. Pelosof LC, Gerber DE. Paraneoplastic syndromes: an approach to diagnosis and treatment. Mayo Clin Proc. 2010;85(9):838–54.

    Article  PubMed Central  PubMed  Google Scholar 

  28. Small S, Ali HH, Lennon VA, Brown RHJ, Carr DB, de Armendi A. Anesthesia for an unsuspected Lambert-Eaton myasthenic syndrome with autoantibodies and occult small cell lung carcinoma. Anesthesiology. 1992;76(1):142–5.

    Article  CAS  PubMed  Google Scholar 

  29. Arain MR, Buggy DJ. Anaesthesia for cancer patients. Curr Opin Anaesthesiol. 2007;20(3):247–53.

    Article  PubMed  Google Scholar 

  30. Dunn A, Carter J, Carter H. Anemia at the end of life: prevalence, significance, and causes in patients receiving palliative care. J Pain Symptom Manage. 2003;26(6):1132–9.

    Article  PubMed  Google Scholar 

  31. Falanga A, Russo LV, Verzeroli C. Mechanisms of thrombosis in cancer. Thromb Res. 2013;131 Suppl 1:S59–62.

    Article  CAS  PubMed  Google Scholar 

  32. Mughal TI, Ejaz AA, Foringer JR, Coiffier B. An integrated clinical approach for the identification, prevention, and treatment of tumor lysis syndrome. Cancer Treat Rev. 2010;36(2):164–76.

    Article  PubMed  Google Scholar 

  33. Lee MH, Cheng KI, Jang RC, Hsu JH, Dai ZK, Wu JR. Tumour lysis syndrome developing during an operation. Anaesthesia. 2007;62(1):85–7.

    Article  CAS  PubMed  Google Scholar 

  34. MacDonald N, Easson AM, Mazurak VC, Dunn GP, Baracos VE. Understanding and managing cancer cachexia. J Am Coll Surg. 2003;197(1):143–61.

    Article  PubMed  Google Scholar 

  35. Raspe C, Piso P, Wiesenack C, Bucher M. Anesthetic management in patients undergoing hyperthermic chemotherapy. Curr Opin Anaesthesiol. 2012;25(3):348–55.

    Article  CAS  PubMed  Google Scholar 

  36. Allan N, Siller C, Breen A. Anaesthetic implications of chemotherapy. Contin Educ Anaesth Crit Care Pain. 2012;12(2):52–6.

    Article  Google Scholar 

  37. Yeh ET, Tong AT, Lenihan DJ, Yusuf SW, Swafford J, Champion C, et al. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation. 2004;109(25):3122–31.

    Article  PubMed  Google Scholar 

  38. Meadors M, Floyd J, Perry MC. Pulmonary toxicity of chemotherapy. Semin Oncol. 2006;33(1):98–105.

    Article  CAS  PubMed  Google Scholar 

  39. de Jonge MJ, Verweij J. Renal toxicities of chemotherapy. Semin Oncol. 2006;33(1):68–73.

    Article  PubMed  Google Scholar 

  40. Huettemann E, Sakka SG. Anaesthesia and anti-cancer chemotherapeutic drugs. Curr Opin Anaesthesiol. 2005;18(3):307–14.

    Article  PubMed  Google Scholar 

  41. Floyd J, Mirza I, Sachs B, Perry MC. Hepatotoxicity of chemotherapy. Semin Oncol. 2006;33(1):50–67.

    Article  CAS  PubMed  Google Scholar 

  42. Goldiner PL, Carlon GC, Cvitkovic E, Schweizer O, Howland WS. Factors influencing postoperative morbidity and mortality in patients treated with bleomycin. Br Med J. 1978;24(1):1664–7.

    Article  Google Scholar 

  43. Froudarakis M, Hatzimichael E, Kyriazopoulou L, Lagos K, Pappas P, Tzakos AG, et al. Revisiting bleomycin from pathophysiology to safe clinical use. Crit Rev Oncol Hematol. 2013;87(1):90–100.

    Article  PubMed  Google Scholar 

  44. O’Sullivan JM, Huddart RA, Norman AR, Nicholls J, Dearnaley DP, Horwich A. Predicting the risk of bleomycin lung toxicity in patients with germ-cell tumours. Ann Oncol. 2003;14(1):91–6.

    Article  PubMed  Google Scholar 

  45. Merrill WW. Radiation-induced lung injury. In: Kavanagh B, Hollingsworth H, editors. UpToDate. Waltham: UpToDate; 2013.

    Google Scholar 

  46. Galloway T, Amdur RJ. Management of late complications of head and neck cancer and its treatment. In: Basow DS, editor. UpToDate. Waltham, MA: UpToDate; 2013.

    Google Scholar 

  47. McCann S, Yaksh TL, von Gunten CF. Correlation between myoclonus and the 3-glucuronide metabolites in patients treated with morphine or hydromorphone: a pilot study. J Opioid Manag. 2010;6(2):87–94.

    Article  PubMed  Google Scholar 

  48. Zaniboni A, Prabhu S, Audisio RA. Chemotherapy and anaesthetic drugs: too little is known. Lancet Oncol. 2005;6(3):176–81.

    Article  CAS  PubMed  Google Scholar 

  49. Mols G, Priebe HJ, Guttmann J. Alveolar recruitment in acute lung injury. Br J Anaesth. 2006;96(2):156–66.

    Article  CAS  PubMed  Google Scholar 

  50. Ferrer M, Valencia M, Nicolas JM, Bernadich O, Badia JR, Torres A. Early noninvasive ventilation averts extubation failure in patients at risk: a randomized trial. Am J Respir Crit Care Med. 2006;173(2):164–70.

    Article  PubMed  Google Scholar 

  51. Nava S, Gregoretti C, Fanfulla F, Squadrone E, Grassi M, Carlucci A, et al. Noninvasive ventilation to prevent respiratory failure after extubation in high-risk patients. Crit Care Med. 2005;33(11):2465–70.

    Article  PubMed  Google Scholar 

  52. Nethercott D, Strang T, Krysiak P. Airway stents: anaesthetic implications Contin Educ Anaesth Crit Care Pain. 2010;10(2):53–8.

    Google Scholar 

  53. Mercadante S. Intravenous patient-controlled analgesia and management of pain in post-surgical elderly with cancer. Surg Oncol. 2010;19(3):173–7.

    Article  PubMed  Google Scholar 

  54. Racca F, Mongini T, Wolfler A, Vianello A, Cutrera R, Del Sorbo L, et al. Recommendations for anesthesia and perioperative management of patients with neuromuscular disorders. Minerva Anestesiol. 2013;79(4):419–33.

    CAS  PubMed  Google Scholar 

  55. Australian Red Cross Blood Service. Blood component information: a circular of information. Melbourne, Australia: Australian Red Cross Blood Service; 2012.

    Google Scholar 

  56. Ferguson JK. Preventing healthcare-associated infection: risks, healthcare systems and behaviour. Intern Med J. 2009;39(9):574–81.

    Article  CAS  PubMed  Google Scholar 

  57. Denkinger CM, Grant AD, Denkinger M, Gautam S, D’Agata EM. Increased multi-drug resistance among the elderly on admission to the hospital – a 12-year surveillance study. Arch Gerontol Geriatr. 2013;56(1):227–30.

    Article  CAS  PubMed  Google Scholar 

  58. Cavaliere S, Venuta F, Foccoli P, Toninelli C, La Face B. Endoscopic treatment of malignant airway obstructions in 2,008 patients. Chest. 2006;110(6):1536–42.

    Article  Google Scholar 

  59. Profili S, Manca A, Feo CF, Padua G, Ortu R, Canalis GC, et al. Palliative airway stenting performed under radiological guidance and local anesthesia. Cardiovasc Intervent Radiol. 2007;30(1):74–8.

    Article  PubMed  Google Scholar 

  60. Coolen D, Slabbynck H, Galdermans D, Van Schaardenburg C, Mortelmans LL. Insertion of a self-expandable endotracheal metal stent using topical anaesthesia and a fibreoptic bronchoscope: a comfortable way to offer palliation. Thorax. 1994;49(1):87–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  61. Benrath J, Kozek-Langenecker S, Hüpfl M, Lierz P, Gustorff B. Anaesthesia for brachytherapy–51/2 yr of experience in 1622 procedures. Br J Anaesth. 2006;96(2):195–200.

    Article  CAS  PubMed  Google Scholar 

  62. Roessler B, Six LM, Gustorff B. Anaesthesia for brachytherapy. Curr Opin Anaesthesiol. 2008;21(4):514–8.

    Article  PubMed  Google Scholar 

  63. Bryson EO, Sejpal D. Anesthesia in remote locations: radiology and beyond, international anesthesiology clinics: gastroenterology: endoscopy, colonoscopy, and ERCP. Int Anesthesiol Clin. 2009;47(2):69–80.

    Article  PubMed  Google Scholar 

  64. Reed H. The development of an extended care facility in the recovery unit: the post-anaesthesia care unit. J Perioper Pract. 2011;21(6):210–4.

    PubMed  Google Scholar 

  65. IASP Task Force on Taxonomy. In: Merskey H, Bogduk N, editors. Classification of chronic pain. Seattle: IASP Press; 1994.

    Google Scholar 

  66. Taskforce on Acute Pain. In: Ready BL, Edwards WT, editors. Management of acute pain: a practical guide. Seattle: IASP Press; 1992.

    Google Scholar 

  67. Loeser JD, Treede RD. The Kyoto protocol of IASP basic pain terminology. Pain. 2008;137(3):473–7.

    Article  PubMed  Google Scholar 

  68. Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367(9522):1618–25.

    Article  PubMed  Google Scholar 

  69. World Health Organization. Cancer pain relief: with a guide to opioid availability. Geneva: WHO; 1996.

    Google Scholar 

  70. APM: SE Working Group of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine. Acute Pain Management: Scientific Evidence. In: Macintyre PE, Schug SA, Scott DA, Visser EJ, Walker SM, editors. Melbourne: ANZCA & FPM; 2010.

    Google Scholar 

  71. Wu CL, Cohen SR, Richman JM, Rowlingson AJ, Courpas GE, Cheung K, et al. Efficacy of postoperative patient-controlled and continuous infusion epidural analgesia versus intravenous patient-controlled analgesia with opioids: a meta-analysis. Anesthesiology. 2005;103(5):1079–88.

    Article  CAS  PubMed  Google Scholar 

  72. Rigg JR, Jamrozik K, Myles PS, Silbert BS, Peyton PJ, Parsons RW, et al. Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial. Lancet. 2002;359(9314):1276–82.

    Article  PubMed  Google Scholar 

  73. Dunn GP. Patient assessment in palliative care: How to see the “big picture” and what to do when “there is no more we can do”. J Am Coll Surg. 2001;193(5):565–73.

    Article  CAS  PubMed  Google Scholar 

  74. Dunn GP, Milch RA. Is this a bad day, or one of the last days? How to recognize and respond to approaching demise. J Am Coll Surg. 2002;195(6):879–87.

    Article  PubMed  Google Scholar 

  75. Mosenthal AC, Lee KF. Management of dyspnea at the end of life: relief for patients and surgeons. J Am Coll Surg. 2002;194(3):377–86.

    Article  PubMed  Google Scholar 

  76. American Society of Anesthesiologists Committee of Ethics. Ethical guidelines for the anesthesia care of patients with do-not-resuscitate orders or other directives that limit treatment. Park Ridge, Illinois: American Society of Anesthesiologists; 2008.

    Google Scholar 

  77. Beauchamp TL, Childress JF. Principles of biomedical ethics. Oxford, United Kingdom: Oxford University Press; 2012.

    Google Scholar 

  78. Scott TH, Gavrin JR. Palliative surgery in the do-not-resuscitate patient: ethics and practical suggestions for management. Anesthesiol Clin. 2012;30(1):1–12.

    Article  PubMed  Google Scholar 

  79. Rothenberg DM. Informed refusal - DNR orders in the patient undergoing anesthesia and surgery at the end-of-life. In: Van Norman GA, Jackson S, Rosenbaum SH, Palmer SK, editors. Clinical ethics in anesthesiology. New York: Cambridge University Press; 2011.

    Google Scholar 

  80. The SUPPORT, Investigators P. A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). JAMA. 1995;274(20):1591–8.

    Article  Google Scholar 

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Correspondence to Bernhard Riedel MBChB, FANZCA, MBA, PhD .

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Ferguson, M., Hiller, J.G., Riedel, B. (2014). Anaesthetic Considerations. In: Wichmann, M., Maddern, G. (eds) Palliative Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-53709-7_4

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