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Novel Targets for Treatment of Pseudomonas aeruginosa Biofilms

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Antibiofilm Agents

Part of the book series: Springer Series on Biofilms ((BIOFILMS,volume 8))

Abstract

Pseudomonas aeruginosa causes infection in all parts of the human body. The bacterium is naturally resistant to a wide range of antibiotics. In addition to resistance mechanisms such as efflux pumps, the ability to form aggregates, known as biofilm, further reduces Pseudomonas aeruginosa’s susceptibility to antibiotics. The presence of such biofilms is acknowledged to equal a persistent infection due to their inherent high tolerance to all antimicrobials and immune cells. In this chapter we discuss the mechanisms of biofilm tolerance. The latest biofilm research is reviewed and future treatment strategies such as quorum sensing inhibitors, silver, and antibodies are thoroughly evaluated.

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Authors and Affiliations

  1. Department of International Health, Immunology and Microbiology, University of Copenhagen, 2200, Copenhagen, Denmark

    Morten Alhede, Maria Alhede & Thomas Bjarnsholt

  2. Department of Clinical Microbiology, Rigshospitalet, 2100, Copenhagen, Denmark

    Morten Alhede & Thomas Bjarnsholt

  3. Institute of International Health, Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark

    Thomas Bjarnsholt

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  1. Morten Alhede
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  2. Maria Alhede
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  3. Thomas Bjarnsholt
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Correspondence to Thomas Bjarnsholt .

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Editors and Affiliations

  1. Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

    Kendra P. Rumbaugh

  2. Department of Ag. Microbiology, Aligarh Muslim University, Aligarh, India

    Iqbal Ahmad

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Alhede, M., Alhede, M., Bjarnsholt, T. (2014). Novel Targets for Treatment of Pseudomonas aeruginosa Biofilms. In: Rumbaugh, K., Ahmad, I. (eds) Antibiofilm Agents. Springer Series on Biofilms, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-53833-9_12

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