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Stereotactic Radiotherapy of Uveal Melanoma

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Clinical Ophthalmic Oncology

Abstract

Stereotactic radiotherapy involves the precise positioning of the tumor in three-dimensional space by appropriate scanning and the delivery of ionizing radiation to the tumor from multiple directions [1]. A high dose of radiation is therefore focused at the target with relatively little irradiation of the surrounding healthy tissues.

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References

  1. McKenzie MR, Ma R, Clark B, et al. Stereotactic radiosurgery and radiation therapy in British Columbia. B C Med J. 2001;43:567–72.

    Google Scholar 

  2. Langmann G, Wackernagel W, Stucklschweiger G, Feichtinger K, Papaefthymiou G, Faulborn J. [Dose-volume histogram regression analysis of uveal melanomas after single fraction gamma knife radiosurgery]. Ophthalmologe. 2004;101(11):1111–9.

    Article  CAS  PubMed  Google Scholar 

  3. Langmann G, Pendl G, Mullner K, Feichtinger KH, Papaefthymiouaf G. High-compared with low-dose radiosurgery for uveal melanomas. J Neurosurg. 2002;97(5 Suppl):640–3.

    PubMed  Google Scholar 

  4. Zehetmayer M, Menapace R, Kitz K, Ertl A. Suction fixation system for stereotactic radiosurgery of intraocular malignancies. Acta Neurochir Suppl. 1995;63:115–8.

    CAS  PubMed  Google Scholar 

  5. Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand. 1951;102(4):316–9.

    CAS  PubMed  Google Scholar 

  6. Wackernagel W, Holl E, Tarmann L, Avian A, Schneider MR, Kapp K, et al. Visual acuity after gamma-knife radiosurgery of choroidal melanomas. Br J Ophthalmol. 2013;97(2):153–8.

    PubMed  Google Scholar 

  7. Dinca EB, Yianni J, Rowe J, Radatz MW, Preotiuc-Pietro D, Rundle P, et al. Survival and complications following gamma knife radiosurgery or enucleation for ocular melanoma: a 20-year experience. Acta Neurochir. 2012;154(4):605–10.

    PubMed  Google Scholar 

  8. Modorati G, Miserocchi E, Galli L, Picozzi P, Rama P. Gamma knife radiosurgery for uveal melanoma: 12 years of experience. Br J Ophthalmol. 2009;93(1):40–4.

    CAS  PubMed  Google Scholar 

  9. Zehetmayer M, Kitz K, Menapace R, Ertl A, Heinzl H, Ruhswurm I, et al. Local tumor control and morbidity after one to three fractions of stereotactic external beam irradiation for uveal melanoma. Radiother Oncol. 2000;55(2):135–44.

    CAS  PubMed  Google Scholar 

  10. Rennie I, Forster D, Kemeny A, Walton L, Kunkler I. The use of single fraction Leksell stereotactic radiosurgery in the treatment of uveal melanoma. Acta Ophthalmol Scand. 1996;74(6):558–62.

    Article  CAS  PubMed  Google Scholar 

  11. Marchini G, Babighian S, Tomazzoli L, Gerosa MA, Nicolato A, Bricolo A, et al. Stereotactic radiosurgery of uveal melanomas: preliminary results with Gamma Knife treatment. Stereotact Funct Neurosurg. 1995;64 Suppl 1:72–9.

    PubMed  Google Scholar 

  12. Logani S, Cho AS, Ali BH, Withers HR, McBride WH, Kozlov KL, et al. Single-dose compared with fractionated-dose radiation of the OM431 choroidal melanoma cell line. Am J Ophthalmol. 1995;120(4):506–10.

    CAS  PubMed  Google Scholar 

  13. Mueller AJ, Talies S, Schaller UC, Hoops JP, Schriever S, Kampik A, et al. [Stereotaxic precision irradiation of large uveal melanomas with the gamma knife]. Ophthalmologe. 2000;97(8):537–45.

    Article  CAS  PubMed  Google Scholar 

  14. Simonova G, Novotny Jr J, Liscak R, Pilbauer J. Leksell gamma knife treatment of uveal melanoma. J Neurosurg. 2002;97(5 Suppl):635–9.

    PubMed  Google Scholar 

  15. Cohen VM, Carter MJ, Kemeny A, Radatz M, Rennie IG. Metastasis-free survival following treatment for uveal melanoma with either stereotactic radiosurgery or enucleation. Acta Ophthalmol Scand. 2003;81(4):383–8.

    Article  CAS  PubMed  Google Scholar 

  16. Dieckmann K, Georg D, Zehetmayer M, Rottenfusser A, Potter R. Stereotactic photon beam irradiation of uveal melanoma: indications and experience at the University of Vienna since 1997. Strahlenther Onkol. 2007;183 Spec No 2:11–3.

    Article  PubMed  Google Scholar 

  17. Muller K, Nowak PJ, de Pan C, Marijnissen JP, Paridaens DA, Levendag P, et al. Effectiveness of fractionated stereotactic radiotherapy for uveal melanoma. Int J Radiat Oncol Biol Phys. 2005;63(1):116–22.

    Article  PubMed  Google Scholar 

  18. Dieckmann K, Bogner J, Georg D, Zehetmayer M, Kren G, Potter R. A linac-based stereotactic irradiation technique of uveal melanoma. Radiother Oncol. 2001;61(1):49–56.

    CAS  PubMed  Google Scholar 

  19. Petersch B, Bogner J, Dieckmann K, Potter R, Georg D. Automatic real-time surveillance of eye position and gating for stereotactic radiotherapy of uveal melanoma. Med Phys. 2004;31(12):3521–7.

    Article  PubMed  Google Scholar 

  20. Georg D, Dieckmann K, Bogner J, Zehetmayer M, Potter R. Impact of a micromultileaf collimator on stereotactic radiotherapy of uveal melanoma. Int J Radiat Oncol Biol Phys. 2003;55(4):881–91.

    Article  PubMed  Google Scholar 

  21. Weber DC, Bogner J, Verwey J, Georg D, Dieckmann K, Escude L, et al. Proton beam radiotherapy versus fractionated stereotactic radiotherapy for uveal melanomas: A comparative study. Int J Radiat Oncol Biol Phys. 2005;63(2):373–84.

    Article  PubMed  Google Scholar 

  22. Dunavoelgyi R, Dieckmann K, Gleiss A, Sacu S, Kircher K, Georgopoulos M, et al. Local tumor control, visual acuity, and survival after hypofractionated stereotactic photon radiotherapy of choroidal melanoma in 212 patients treated between 1997 and 2007. Int J Radiat Oncol Biol Phys. 2011;81(1):199–205.

    Article  PubMed  Google Scholar 

  23. Dunavoelgyi R, Dieckmann K, Gleiss A, Sacu S, Kircher K, Georgopoulos M, et al. Radiogenic side effects after hypofractionated stereotactic photon radiotherapy of choroidal melanoma in 212 patients treated between 1997 and 2007. Int J Radiat Oncol Biol Phys. 2012;83(1):121–8.

    Article  PubMed  Google Scholar 

  24. Tokuuye K, Akine Y, Sumi M, Kagami Y, Ikeda H, Kaneko A. Fractionated stereotactic radiotherapy for choroidal melanoma. Radiother Oncol. 1997;43(1):87–91.

    CAS  PubMed  Google Scholar 

  25. Muller K, Nowak PJ, Luyten GP, Marijnissen JP, de Pan C, Levendag P. A modified relocatable stereotactic frame for irradiation of eye melanoma: design and evaluation of treatment accuracy. Int J Radiat Oncol Biol Phys. 2004;58(1):284–91.

    Article  PubMed  Google Scholar 

  26. Krema H, Somani S, Sahgal A, Xu W, Heydarian M, Payne D, et al. Stereotactic radiotherapy for treatment of juxtapapillary choroidal melanoma: 3-year follow-up. Br J Ophthalmol. 2009;93(9):1172–6.

    Article  CAS  PubMed  Google Scholar 

  27. Al-Wassia R, Dal Pra A, Shun K, Shaban A, Corriveau C, Edelstein C, et al. Stereotactic fractionated radiotherapy in the treatment of juxtapapillary choroidal melanoma: the McGill University experience. Int J Radiat Oncol Biol Phys. 2011;81(4):e455–62.

    Article  PubMed  Google Scholar 

  28. van den Aardweg GJ, Kilic E, de Klein A, Luyten GP. Dose fractionation effects in primary and metastatic human uveal melanoma cell lines. Invest Ophthalmol Vis Sci. 2003;44(11):4660–4.

    Article  PubMed  Google Scholar 

  29. Bornfeld N, Talies S, Anastassiou G, Schilling H, Schuler A, Horstmann GA. [Endoscopic resection of malignant melanomas of the uvea after preoperative stereotactic single dose convergence irradiation with the Leksell gamma knife]. Ophthalmologe. 2002;99(5):338–44.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors would like to thank their coworkers for their contributions and Heimo Bauer for his technical assistance in preparing the Figs. 15.1–15.4.

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Correspondence to Gerald Langmann .

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Dieckmann, K. et al. (2014). Stereotactic Radiotherapy of Uveal Melanoma. In: Damato, B., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54255-8_15

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  • DOI: https://doi.org/10.1007/978-3-642-54255-8_15

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