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Posterior Uveitis

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Immune Modulation and Anti-Inflammatory Therapy in Ocular Disorders

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Abstract

Posterior uveitis (PU) represents a category of ocular inflammatory diseases, which can lead to a severe visual impairment. Many infectious agents can be the trigger of PU, such as Toxoplasma gondii, Toxocara canis, Mycobacterium tuberculosis, and syphilis. In addition, very recently, other infectious agents have been recognized as promoters of PU. Among these new entities, we recognize the West Nile fever virus, chikungunya virus, and spirochetes of the genus Leptospira.

Noninfectious uveitis is another subgroup, which is included in the family of PU. This category includes a wide spectrum of posterior uveitis which is characterized by a heterogeneous pattern of presentation. The therapeutic management is still a challenge for ocular immunologists and the hottest topic of such scientific area. In this chapter, we will show the clinical assessment and the therapeutic techniques used for the management of such diseases.

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Authors and Affiliations

  1. Ospedali Riuniti “Umberto I-GM Lancisi-G Salesi”, The Eye Clinic-Polytechnic University of Marche, Via Conca, n.71, Ancona, 60020, Italy

    Piergiorgio Neri BMedSc, MD, PhD, Alfonso Giovannini MD & Cesare Mariotti MD

  2. Department of Neuroscience, Ospedali Riuniti di Ancona, Università Politecnica delle Marche, Via Conca, n.71, Ancona, 60126, Italy

    Ilir Arapi MSc, MD & Vittorio Pirani MSc, MD

  3. Department of Ophthalmology, Charité, Augustenburger Platz 1, Berlin, 13353, Germany

    Uwe Pleyer MD, FEBO & Michele Nicolai MSc, MD

  4. Department of Opthalmology, Fattouma Bourguiba University Hospital, 1st June Street, Monastir, 5019, Tunisia

    Moncef Khairallah MD

  5. Retina-vitreous and Uvea Service, L V Prasad Eye Institute, Patia, Bhubaneswar, Odisha, 751024, India

    Soumyava Basu MS

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  1. Piergiorgio Neri BMedSc, MD, PhD
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Correspondence to Piergiorgio Neri BMedSc, MD, PhD .

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  1. Department of Ophthalmology, Charité Campus Virchow-Klinikum, Berlin, Germany

    Uwe Pleyer

  2. Division of Ophthalmology, Miguel Hernandez University, Vissum-Instituto Oftalmologico de Alicante, Alicante, Spain

    Jorge L. Alió

  3. Centre of Ocular Inflammation and Infection OCUVAC, Medical University of Vienna Laura Bassi Centre of Expertise, Vienna, Austria

    Talin Barisani-Asenbauer

  4. Department of Ophthalmology, Pitié-Salpêtrière’s University Hospital, Paris, France

    Phuc Le Hoang

  5. Doheny Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA

    Narsing A. Rao

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Neri, P. et al. (2014). Posterior Uveitis. In: Pleyer, U., Alió, J., Barisani-Asenbauer, T., Le Hoang, P., Rao, N. (eds) Immune Modulation and Anti-Inflammatory Therapy in Ocular Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54350-0_10

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