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Swine Hepatitis E Virus: Cross-Species Infection and Risk in Xenotransplantation

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Xeno-transplantation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 278))

Abstract

Swine hepatitis E Virus (swine HEV), a ubiquitous agent recently discovered in pigs, is antigenically and genetically closely related to the human HEV. Swine HEV infection in pigs generally occurs at about 2-3 months of age, and about 80%-100% of the pigs in commercial farms in the USA were infected. Swine HEV infections have now been recognized in pigs in many other countries of the world. Interspecies transmission has been documented, as swine HEV infects nonhuman primates and some strains of human HEV infect pigs. Recent seroepidemiological studies showed that swine veterinarians and other pig handlers are at higher risk of HEV infection compared to normal blood donors. In addition, novel strains of human HEV recovered from hepatitis patients in the USA, Japan and Taiwan are genetically more closely related to strains of swine HEV from respective countries than to other strains of human HEV. The ubiquitous nature of the virus in pigs and the demonstrated ability of cross-species infection raise a potential concern for swine HEV infection in xenotransplantation with pig organs. This chapter discusses the recent advances in HEV research with emphases on potential zoonosis and xenozoonosis.

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References

  • Aggarwal R, Krawczynski K (2000) Hepatitis E: An overview and recent advances in clinical and laboratory research. J Gastroenterol Hepatol 15:9–20

    Article  PubMed  CAS  Google Scholar 

  • Arankalle VA, Tsarev SA, Chadha MS, Alling DW, Emerson SU, Banerjee K, Purcell RH (1995) Age-specific prevalence of antibodies to hepatitis A and E viruses in Pune, India, 1982 and 1992. J Infect Dis 171:447–450

    Article  PubMed  CAS  Google Scholar 

  • Arankalle VA, Chadha MS, Tsarev SA, Emerson SU, Risbud AR, Banerjee K, Purcell RH (1994) Seroepidemiology of water-born hepatitis in India and evidence for a third enterically-transmitted hepatitis agent. Proc Natl Acad Sci USA 91:3428–3432

    Article  PubMed  CAS  Google Scholar 

  • Arankalle VA, Joshi MV, Kulkarni AM, Gandhe S, Chobe L, Rautmare S, Mishra A, Padbidri V (2001) Prevalence of anti-hepatitis E virus antibodies in different Indian animal species. J Viral Hepat 8:223–227

    Article  PubMed  CAS  Google Scholar 

  • Balayan MS, Andjaparidze AG, Savinskaya SS, Ketiladze ES, Braginsky DM, Savinov AP, Poleschuk VF (1983) Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology 20:23–31

    Article  PubMed  CAS  Google Scholar 

  • Balayan MS, Usmanov RK, Zamyatina DI, Karas FR (1990) Brief report: experimental hepatitis E infection in domestic pigs. J Med Virol 32:58–59

    Article  PubMed  CAS  Google Scholar 

  • Buisson Y, Grandadam, Nicand ME, Cheval P, Van Cuyck-Gandre H, Innis B, Rehel P, Coursaget P, Teyssou R, Tsarev S (2000) Identification of a novel hepatitis E virus in Nigeria. J Gen Virol 81:903–909

    PubMed  CAS  Google Scholar 

  • Chandler JD, Riddell MA, Li F, Love RJ, Anderson DA (1999) Serological evidence for swine hepatitis E virus infection in Australian pig herds. Vet Microbiol 68:95–105

    Article  PubMed  CAS  Google Scholar 

  • Clayson ET, Innis BL, Myint KS, Narupiti S, Vaughn DW, Giri S, Ranabhat P, Shrestha MP (1995) Detection of hepatitis E virus infections among domestic swine in the Kathmandu Valley of Nepal. Am J Trop Med Hyg 53:228–232

    PubMed  CAS  Google Scholar 

  • Drobeniuc J, Favorov MO, Shapiro CN, Bell BP, Mast EE, Dadu A, Culver D, Iarovoi P, Robertson BH, Margolis HS (2001) Hepatitis E virus antibody prevalence among persons who work with swine. J Infect Dis 184:1594–1597

    Article  PubMed  CAS  Google Scholar 

  • Emerson SU, Zhang M, Meng XJ, Nguyen H, Huang Y, Purcell RH (2001) Recombinant hepatitis E virus genomes infectious for primates: Importance of capping and discovery of a cis-reactive element. Proc Natl Acad Sci USA 98:15270–15275

    Article  PubMed  CAS  Google Scholar 

  • Engle RE, Yu C, Emerson SU, Meng XJ, Purcell RH (2002) Hepatitis E virus (HEV) capsid antigens derived from viruses of human and swine origin are equally efficient for detecting anti-HEV by enzyme immunoassay. J Clin Microbiol 40: 4576–4580

    Article  PubMed  CAS  Google Scholar 

  • Erker JC, Desai SM, Schlauder GG, Dawson GJ, Mushahwar IK (1999) A hepatitis E virus variant from the United States: molecular characterization and transmission in cynomolgus macaques. J Gen Virol 80:681–690

    PubMed  CAS  Google Scholar 

  • Fagan EA, Harrison TJ (2000) Viral Hepatitis. Springer-Verlag New York Inc. P.62–88

    Google Scholar 

  • Favorov MO, Kosoy MY, Tsarev SA, Childs JE, Margolis HS (2000) Prevalence of antibody to hepatitis E virus among rodents in the United States. J Infect Dis 181:449–455

    Article  PubMed  CAS  Google Scholar 

  • Favorov MO, Nazarova O, Margolis HS (1998) Is hepatitis E an emerging zoonotic disease? Am J Trop Med Hyg 59:242

    Google Scholar 

  • Fix AD, Abdel-Hamid M, Purcell RH, Shehata MH, Abdel-Aziz F, Mikhail N, El Sebai H, Nafeh M, Habib M, Arthur RR, Emerson SU, Strickland GT (2000) Prevalence of antibodies to hepatitis E in two rural Egyptian communities. Am J Trop Med Hyg 62:519–523

    PubMed  CAS  Google Scholar 

  • Fry KE, Tam AW, Smith MM, Kim JP, Luk KC, Young LM, Piatak M, Feldman RA, Yun KY, Purdy MA, et al. (1992) Hepatitis E virus (HEV): strain variation in the nonstructural gene region encoding consensus motifs for an RNA-dependent RNA polymerase and an ATP/GTP binding site. Virus Genes 6:173–185

    Article  PubMed  CAS  Google Scholar 

  • Garkavenko O, Obriadina A, Meng J, Anderson DA, Benard HJ, Schroeder BA, Khudyakov YE, Fields HA, Croxson MC (2001) Detection and characterization of swine hepatitis E virus in New Zealand. J Med Virol 65:525–529

    Article  PubMed  CAS  Google Scholar 

  • Halbur PG, Kasorndorkbua C, Gilbert C, Guenette D, Potters MB, Purcell RH, Emerson SU, Toth TE, Meng XJ (2001) Comparative pathogenesis of infection of pigs with hepatitis E viruses recovered from a pig and a human. J Clin Microbiol 39 918–923

    Article  PubMed  CAS  Google Scholar 

  • Haqshenas G, Shivaprasad HL, Woolcock P, Read DH, Meng XJ (2001) Genetic dentification and characterization of a novel virus related to the human hepatitis E virus from chickens with Hepatitis-Splenomegaly Syndrome in the United States. J Gen Virol 82:2449–2462

    PubMed  CAS  Google Scholar 

  • Haqshenas G, Meng XJ (2001) Determination of the nucleotide sequences at the extreme 5_ and 3_ ends of swine hepatitis E virus genome. Arch Virol 146:2461–2467

    Article  PubMed  CAS  Google Scholar 

  • Haqshenas G, Huang FF, Fenaux M, Guenette DK, Pierson FW, Larsen CT, Shivaprasad HL, Toth TE, Meng XJ (2002) The putative capsid protein of the newly identified avian hepatitis E virus shares antigenic epitopes with that of swine and human hepatitis E viruses and the chicken big liver and spleen disease virus. J Gen Virol 83: 2201–2209

    PubMed  CAS  Google Scholar 

  • Hsieh SY, Yang PY, Ho YP, Chu CM, Liaw YF (1998) Identification of a novel strain of hepatitis E virus responsible for sporadic acute hepatitis in Taiwan. J Med Virol 55:300–304

    Article  PubMed  CAS  Google Scholar 

  • Hsieh SY, Meng XJ, Wu YH, Liu ST, Tam AW, Lin DY, Liaw YF (1999) Identity of a novel swine hepatitis E virus in Taiwan forming a monophyletic group with Taiwan isolates of human hepatitis E virus. J Clin Microbiol 37:3828–3834

    PubMed  CAS  Google Scholar 

  • Huang CC, Nguyen D, Fernandez J, Yun KY, Fry KE, Bradley DW, Tam AW, Reyes GR (1992) Molecular cloning and sequencing of the Mexico isolate of hepatitis E virus (HEV). Virology 191:550–558

    Article  PubMed  CAS  Google Scholar 

  • Huang FF, Haqshenas G, Guenette DK, Halbur PG, Schommer S, Pierson FW, Toth TE, Meng XJ (2002a) Detection by RT-PCR and genetic characterization of field isolates of swine hepatitis E virus from pigs in different geographic regions of the U.S. J Clin Microbiol 40: 1326–1332

    Article  CAS  Google Scholar 

  • Huang FF, Haqshenas G, Shivaprasad HL, Guenette DK, Woolcock PR, Larsen CT, Pierson FW, Elvinger F, Toth TE, Meng XJ (2002b) Heterogeneity and seroprevalence of a newly identified avian hepatitis E virus from chickens in the United States. J Clin Microbiol 40: 4197–4202

    Article  CAS  Google Scholar 

  • Huang R, Nakazono N, Ishii K, Kawamata O, Kawaguchi R, Tsukada Y (1995) Existing variations on the gene structure of hepatitis E virus strains from some regions of China. J Med Virol 47:303–308

    Article  PubMed  CAS  Google Scholar 

  • Jaiswal SP, Jain AK, Naik G, Soni N, Chitnis DS (2001) Viral hepatitis during pregnancy. Intl J Gynaecol Obstet 72:103–108

    CAS  Google Scholar 

  • Jameel S, Zafrullah M, Ozdener MH, Panda SK (1996) Expression in animal cells and characterization of the hepatitis E virus structural proteins. J Virol 70:207–216.

    PubMed  CAS  Google Scholar 

  • Kabrane-Lazizi Y, Meng XJ, Purcell RH, Emerson SU (1999a) Evidence that the genomic RNA of hepatitis E virus is capped. J Virol 73:8848–8850

    CAS  Google Scholar 

  • Kabrane-Lazizi Y, Fine JB, Elm J, Glass GE, Higa H, Diwan A, Gibbs CJ Jr., Meng XJ, merson SU, Purcell RH (1999b) Evidence for wide-spread infection of wild rats with hepatitis E virus in the United States. Am J Trop Med Hyg 61:331–335

    CAS  Google Scholar 

  • Kabrane-Lazizi Y, Zhang M, Purcell RH, Miller KD, Davey RT, Emerson SU (2001) Acute hepatitis caused by a novel strain of hepatitis E virus most closely related to United States strains. J Gen Virol 82:1687–1693

    PubMed  CAS  Google Scholar 

  • Karetnyi YV, Gilchrist MJ, Naides SJ (1999) Hepatitis E virus infection prevalence among selected populations in Iowa. J Clin Virol 14:51–55

    Article  PubMed  CAS  Google Scholar 

  • Kasorndorkbua C, Halbur PG, Guenette DK, Toth TE, Meng XJ (2002) Use of a swine bioassay and a RT-PCR assay to assess the risk of transmission of swine hepatitis E virus in pigs. J Virol Methods 101:71–78

    Article  PubMed  CAS  Google Scholar 

  • Khuroo MS (1980) Study of an epidemic of non-A, non-B hepatitis: possibility of another human hepatitis virus distinct from post-transfusion non-A, non-B type. Am J Med 68:818–824

    Article  PubMed  CAS  Google Scholar 

  • Koonin EV, Gorbalenya AE, Purdy MA, Rozanov MN, Reyes GR, Bradley DW (1992) Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positivestrand RNA plant and animal viruses. Proc Natl Acad Sci USA 89:8259–8263

    Article  PubMed  CAS  Google Scholar 

  • Krawczynski K, Aggarwal R, Kamili S (2000) Hepatitis E. Infect Dis Clin North Am 14:669–687

    Article  PubMed  CAS  Google Scholar 

  • Li TC, Yamakava Y, Suzuki K, Tatsumi M, Azeez Razak MA, Uchida T, Takeda N, Miyamura T (1997). Expression and self-assembly of empty virus-like particles of hepatitis E virus. J Virol 71:7207–7213

    PubMed  CAS  Google Scholar 

  • Li TC, Zhang J, Shinzawa H, Ishibashi M, Sata M, Mast EE, Kim K, Miyamura T, Takeda N (2000) Empty virus-like particle-based enzyme-linked immunosorbent assay for antibodies to hepatitis e virus. J Med Virol 62:327–333

    Article  PubMed  CAS  Google Scholar 

  • Maneerat Y, Clayson ET, Myint KSA, Young GD, Innis BL (1996) Experimental infection of the laboratory rat with the hepatitis E virus. J Med Virol 48:121–128

    Article  PubMed  CAS  Google Scholar 

  • Mast EE, Kuramoto IK, Favorov MO, Schoening VR, Burkholder BT, Shapiro CN, Holland PV (1997) Prevalence of and risk factors for antibody to hepatitis E virus seroreactivity among blood donors in Northern California. J Infect Dis 176:34–40

    Article  PubMed  CAS  Google Scholar 

  • Meng XJ, Purcell RH, Halbur PG, Lehman JR, Webb DM, Tsareva TS, Haynes JS, Thacker BJ, Emerson SU (1997) A novel virus in swine is closely related to the human hepatitis E virus. Proc Natl Acad Sci USA 94:9860–9865

    Article  PubMed  CAS  Google Scholar 

  • Meng XJ, Halbur PG, Haynes JS, Tsareva TS, Bruna JD, Royer RL, Purcell RH, Emerson SU (1998a) Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV. Arch Virol 143:1405–1415

    Article  CAS  Google Scholar 

  • Meng XJ, Halbur PG, Shapiro MS, Govindarajan S, Bruna JD, Mushahwar IK, Purcell RH, Emerson SU (1998b) Genetic and experimental evidence for cross-species infection by the swine hepatitis E virus. J Virol 72:9714–9721

    CAS  Google Scholar 

  • Meng XJ, Dea S, Engle RE, Friendship R, Lyoo YS, Sirinarumitr T, Urairong TK, Wang D, Wong D, Yoo D, Zhang Y, Purcell RH, Emerson SU (1999) Prevalence of antibodies to the hepatitis E virus in pigs from countries where hepatitis E is common or is rare in the human population. J Med Virol 58:297–302

    Article  Google Scholar 

  • Meng XJ (2000a) Zoonotic and xenozoonotic risks of hepatitis E virus. Infect Dis Rev 2:35–41

    Google Scholar 

  • Meng XJ (2000b) Novel strains of hepatitis E virus identified from humans and other animal species: Is hepatitis E a zoonosis? J Hepatol 33:842–845

    Article  CAS  Google Scholar 

  • Meng XJ, Wiseman B, Elvinger F, Guenette DK, Toth TE, Engel R, Emerson SU, Purcell RH (2002) Prevalence of antibodies to the hepatitis E virus in veterinarians working with swine and normal blood donors in the United States and other countries. J Clin Microbiol 40:117–122

    Article  PubMed  CAS  Google Scholar 

  • Naik SR, Aggarwal R, Salunke PN, Mehrotra NN (1992) A large waterborne viral hepatitis E epidemic in Kanpur, India. Bull WHO 70:597–604.

    PubMed  CAS  Google Scholar 

  • Okamoto H, Takahashi M, Nishizawa T, Fukai K, Muramatsu U, Yoshikawa A (2001). Analysis of the complete genome of indigenous swine hepatitis E virus isolated in Japan. Biochem Biophys Res Commun 289:929–936

    Article  PubMed  CAS  Google Scholar 

  • Payne CJ, Ellis TM, Plant SL, Gregory AR, Wilcox GE (1999) Sequence data suggests big liver and spleen disease virus (BLSV) is genetically related to hepatitis E virus. Vet Microbiol 68:119–125

    Article  PubMed  CAS  Google Scholar 

  • Pina S, Buti M, Cotrina M, Piella J, Girones R (2000) HEV identified in serum from humans with acute hepatitis and in sewage of animal origin in Spain. J Hepatol 33:826–833

    Article  PubMed  CAS  Google Scholar 

  • Platt KB, Yoon KJ, Zimmerman JJ (1998) Susceptibility of swine to hepatitis E virus and its significance to human health. Swine Research Report, Iowa State University, Ames, IA, 125–126

    Google Scholar 

  • Pringle C (1998) Minutes of the 27th International Committee on Taxonomy of Viruses Meeting. Arch Virol 143:1449–1459

    Article  PubMed  CAS  Google Scholar 

  • Purcell RH (1996) Hepatitis E virus. In: Fields BN, Knipe DM, Howley PM et al. (eds) Fields Virology. 3rd ed. Vol 2. Lippincott-Raven Publishers, Philadelphia p.2831–2843

    Google Scholar 

  • Reyes GR, Purdy MA, Kim JP, Luk KC, Young LM, Fry KE, Bradley DW (1990) Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis. Science 247:1335–1339

    Article  PubMed  CAS  Google Scholar 

  • Reyes GR (1997) Overview of the epidemiology and biology of the hepatitis E virus. In: Willson RA (eds) Viral Hepatitis. Marcel Dekker, Inc., NY, pp.239–258

    Google Scholar 

  • Schlauder GG, Dawson GJ, Erker JC, Kwo PY, Knigge MF, Smalley DL, Rosenblatt JE, Desai SM, Mushahwar IK (1998) The sequence and phylogenetic analysis of a novel hepatitis E virus isolated from a patient with acute hepatitis reported in the United States. J Gen Virol 79:447–456

    PubMed  CAS  Google Scholar 

  • Schlauder GG, Desai SM, Zanetti AR, Tassopoulos NC, Mushahwar IK (1999) Novel hepatitis E virus (HEV) isolates from Europe: evidence for additional genotypes of HEV. J Med Virol 57:243–251

    Article  PubMed  CAS  Google Scholar 

  • Schlauder GG, Frider B, Sookoian S, Castano GC, Mushahwar IK (2000) Identification of 2 novel isolates of hepatitis E virus in Argentina. J Infect Dis 182:294–297

    Article  PubMed  CAS  Google Scholar 

  • Takahashi K, Iwata K, Watanabe N, Hatahara T, Ohta Y, Baba K, Mishiro S (2001) Full-genome nucleotide sequence of a hepatitis E virus strain that may be indigenous to Japan. Virology 287:9–12

    Article  PubMed  CAS  Google Scholar 

  • Takahashi K, Kang JH, Ohnishi S, Hino K, Mishiro S (2002) Genetic heterogeneity of hepatitis E virus recovered from Japanese patients with acute sporadic hepatitis. J Infect Dis 185: 1342–1345

    Article  PubMed  CAS  Google Scholar 

  • Tam AW, Smith MM, Guerra ME, Huang CC, Bradley DW, Fry KE, Reyes GR (1991) Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Virology 185:120–131

    Article  PubMed  CAS  Google Scholar 

  • Thomas DL, Yarbough PO, Vlahov D, Tsarev SA, Nelson KE, Saah AJ, Purcell RH (1997) Seroreactivity to hepatitis E virus in areas where the disease is not endemic. J Clin Microbiol 35:1244–1247

    PubMed  CAS  Google Scholar 

  • Ticehurst J, Popkin TJ, Bryan JP, Innis BL, Duncan JF, Ahmed A, Iqbal M, Malik I, Kapikian AZ, Legters LJ, et al. (1992) Association of hepatitis E virus with an outbreak of hepatitis in Pakistan: serologic responses and pattern of virus excretion. J Med Virol. 36:84–92

    Article  PubMed  CAS  Google Scholar 

  • Tien NT, Clayson HT, Khiem HB, Sac PK, Corwin AL, Myint KS, Vaughn DW (1997) Detection of immunoglobulin G to the hepatitis E virus among several animal species in Vietnam. Am J Trop Med Hyg 57:211 (abstract)

    Google Scholar 

  • Tsarev SA, Tsareva TS, Emerson SU, Rippy MK, Zack P, Shapiro M, Purcell RH (1995) Experimental hepatitis E in pregnant rhesus monkeys: failure to transmit hepatitis E virus (HEV) to offspring and evidence of naturally acquired antibodies to HEV. J Infect Dis 172:31–37

    Article  PubMed  CAS  Google Scholar 

  • Tsarev SA, Shrestha MP, He J, Scott RM, Vaughn DW, Clayson ET, Gigliotti S, Longer CF, Innis BL (1998) Naturally acquired hepatitis E virus (HEV) infection in Nepalese rodents. Am J Trop Med Hyg 59:242 (abstract)

    Google Scholar 

  • Usmanov RK, Balayan MS, Dvoinikova OV, Alymbaeva DB, Zamiatina NA, Kazachkov LuA, Belov VI (1994) An experimental infection in lambs by the hepatitis E virus. Voprosy Virusologii 39:165–168

    PubMed  CAS  Google Scholar 

  • Van der Poel W, Verschoor F, van der Heide R, Herrera, MI, Vivo A, Kooreman M, de Roda Husman A (2001) Hepatitis E virus sequences in swine related to sequences in humans, the Netherlands. Emerg Infect Dis 7:970–976

    Article  PubMed  Google Scholar 

  • Vishwanathan R (1957) Infectious hepatitis in Delhi (1955–1956): A critical study: epidemiology. Indian J Med Res 45 (suppl 1):1955–1956

    Google Scholar 

  • Wang Y, Ling R, Erker JC, Zhang H, Li H, Desai S, Mushahwar IK, Harrison TJ (1999) A divergent genotype of hepatitis E virus in Chinese patients with acute hepatitis. J Gen Virol 80:169–177

    PubMed  CAS  Google Scholar 

  • Wang Y, Zhang H, Ling R, Li H, Harrison TJ (2000) The complete sequence of hepatitis E virus genotype 4 reveals an alternative strategy for translation of open reading frames 2 and 3. J Gen Virol 81:1675–1686

    PubMed  CAS  Google Scholar 

  • Williams TPE, Kasorndorkbua C, Halbur PG, Haqshenas G, Guenette DK, Toth TE, Meng XJ (2001) Evidence of extrahepatic sites of replication of the hepatitis E virus in a swine model. J Clin Microbiol 39:3040–3046

    Article  PubMed  CAS  Google Scholar 

  • Weiss RA (1998) Transgenic pigs and virus adaptation. Nature 391:327–328

    Article  Google Scholar 

  • Wong DC, Purcell RH, Sreenivasan MA, Prasad SR, Pavri KM (1980) Epidemic and endemic hepatitis in India: evidence for a non-A, non-B hepatitis virus etiology. Lancet 2:876–879

    Article  PubMed  CAS  Google Scholar 

  • Wu JC, Sheen IJ, Chiang TY, Sheng WY, Wang YJ, Chan CY, Lee SD (1998) The impact of traveling to endemic areas on the spread of hepatitis E virus infection: epidemiological and molecular analyses. J Med Virol 27:1415–1420

    CAS  Google Scholar 

  • Wu JC, Chen CM, Chiang TY, Sheen IJ, Chen JY, Tsai WH, Huang YH, Lee SD (2000) Clinical and epidemiological implications of swine hepatitis E virus infection. J Med Virol 60:166–171

    Article  PubMed  CAS  Google Scholar 

  • Wu JC, Chen CM, Chiang TY, Tsai WH, Jeng WJ, Sheen IJ, Lin CC, Meng XJ (2002) Spreead of hepatitis E virus among different-aged pigs: two year survery in Taiwan. J Med Virol 66: 488–492

    Article  PubMed  Google Scholar 

  • Yoo D, Willson P, Pei Y, Haynes MA, Deckert A, Dewey CE, Friendship RM, Yoon Y, Gottschalk M, Yason C, Giulivi A (2001) Prevalence of hepatitis E virus antibodies in Canadian swine herds and identification of a novel variant of swine hepatitis E virus. Clin Diagn Lab Immunol 8:1213–1219

    PubMed  CAS  Google Scholar 

  • Zafrullah M, Ozdener MH, Panda SK, Jameel S (1997) The ORF3 protein of hepatitis E virus is a phosphoprotein that associated with the cytoskeleton. J Virol 71:9045–9053

    PubMed  CAS  Google Scholar 

  • Zafrullah M., Ozdener MH, Kumar R, Panda SK, Jameel S (1999) Mutational analysis of glycosylation, membrane translocation, and cell surface expression of the hepatitis E virus ORF2 protein. J Virol 73:4074–4082

    PubMed  CAS  Google Scholar 

  • Zanetti AR, Schlauder GG, Romano L, Tanzi E, Fabris P, Dawson GJ, Mushahwar IK (1999) Identification of a novel variant of hepatitis E virus in Italy. J Med Virol 57:356–360

    Article  PubMed  CAS  Google Scholar 

  • Zhang Y, McAtee P, Yarbough PO, Tam AW, Fuerst T (1997) Expression, characterization, and immunoreactivities of a soluble hepatitis E virus putative capsid protein species expressed in insect cells. Clin Diagn Lab Immunol 4:423–428

    PubMed  CAS  Google Scholar 

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  1. Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, 1410 Price’s Fork Road, Blacksburg, VA, 24061-0342, USA

    X. J. Meng

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  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 55, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Daniel R. Salomon M.D.

  2. Division of Cellular and Gene Therapies Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, FDA Building 29B, Room 2NN11 8800 Rockville Pike, HFM-530, Bethesda, MD, 20892, USA

    Carolyn Wilson M.D.

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Meng, X.J. (2003). Swine Hepatitis E Virus: Cross-Species Infection and Risk in Xenotransplantation. In: Salomon, D.R., Wilson, C. (eds) Xeno-transplantation. Current Topics in Microbiology and Immunology, vol 278. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55541-1_7

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