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Does the Gene Encoding Apolipoprotein A-IMilano Protect the Heart?

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Genes and Resistance to Disease

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Abstract

Cardiac protection is generally believed to be exerted by high density lipoproteins (HDL). These lipoproteins can, in fact, remove cholesterol from the arterial wall, thus preventing plaque formation. Plasma levels of HDL are elevated in conditions where the atherosclerosis risk is reduced: women in fertile age, physically fit people, nonsmokers, etc. Conversely, HDL levels are reduced in smokers, diabetics and generally in all conditions leading to an enhanced risk of atherosclerotic vascular disease (Gordon and Rifkind 1989).

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Authors
  1. C. R. Sirtori
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  2. L. Calabresi
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Editors and Affiliations

  1. Human Genetics Department of Noncommunicable Disease Prevention, World Health Organization, 1211 Geneva 27, Switzerland

    V. Boulyjenkov

  2. Institute of Medical Genetics, University of Oslo, Oslo, Norway

    K. Berg

  3. Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    K. Berg

  4. Fondation IPSEN, Pour la Recherche Thérapeutique, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Y. Christen Ph. D.

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Sirtori, C.R., Calabresi, L. (2000). Does the Gene Encoding Apolipoprotein A-IMilano Protect the Heart?. In: Boulyjenkov, V., Berg, K., Christen, Y. (eds) Genes and Resistance to Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56947-0_7

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  • DOI: https://doi.org/10.1007/978-3-642-56947-0_7

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  • Online ISBN: 978-3-642-56947-0

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