Zusammenfassung
Umweltstoffe, gewerbliche Toxine, häusliche und pflanzliche Gifte und schließlich Medikamente bergen Risiken seit alters, und in neuerer Zeit gesellen sich Verunreinigungen von Luft, Wasser und Nahrung hinzu. Die meisten dieser Stoffe und Medikamente insbesondere, treffen vornehmlich und zuerst die Leber als das wesentliche Stoffwechselorgan. Um immer möglichen Schädigungen zu begegnen, hat man sich gewöhnt, jedenfalls die industriellen und pharmakologisch definierten Substanzen auf ihre Toxizität zu überprüfen, im Tierversuch zu testen und — nach ihrer Freigabe — auf unerwartete Wirkungen und Nebenwirkungen besonders zu achten. Trotz alledem sind wir häufig nicht in der Lage, selbst schwere Leberschäden innerhalb einzelner Subpopulationen vorauszusagen, sie, wo sie einmal auftreten, hinreichend rasch zu entdecken und — nach einem Zwischenfall — jeweils einvernehmlich zu klären, was genau sich ereignet, welche abnorme Reaktion stattgefunden hat. Zweifellos wird sich daran auch zukünftig nichts Entscheidendes ändern können; dies umso weniger angesichts einer offenbar zunehmenden Neigung zu Selbstbehandlung, womöglich mit undeklarierten pflanzlichen Zubereitungen (Georgii et al. 1988; Perharic Walton u. Murray 1992; Kane et al. 1995; Larrey u. Pageaux 1995), wodurch es im Ernstfall vollends ausgeschlossen ist, brauchbare Übersicht zu gewinnen.
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Literatur
Alpert LI (1976) Veno-occlusive disease of the liver associated with oral contraceptives. Hum Pathol 7:709–718
Altmann H-W (1976) Morphologie der alkoholbedingten Leberschaden. In: Kühn HA, Wernze H (Hrsg) Klinische Hepatologie. Thieme, Stuttgart, S 6.120–6.132
Altmann H-W (1980a) Drug-induced liver reactions: a morphological approach. Curr Top Pathol 69:69–142
Altmann H-W (1980b) Die granulomatosen Reaktionen der Leber. Verh Dtsch Ges Pathol 64:152–177
Altmann H-W (1990) Onkozytare Hepatozyten. Pathologe 11:137–142
Altmann H-W (1994) Hepatic neoformations. Pathol Res Pract 190:513–577
Arn PH, Hauser ER, Thomas GH, Herman G, Hess D, Brusilow SW (1990) Hyperammonemia in women with a mutation at the ornithine carbamoyltransferase locus. A cause of postpartum coma. N Engl J Med 322:1652–1655
Bagheri SA, Boyer JL (1974) Peliosis hepatis associated with androgenic-anabolic steroid therapy. A severe form of hepatic injury. Ann Intern Med 81:610–618
Le Bail B, Jouhanole H, Deugnier Y, Salame G, Pellegrin J-L, Saric J et al. (1992) Liver adenomatosis with granulomas in two patients on long-term oral contraceptives. Am J Surg Pathol 16:982–987
Balasz M (1988) Sinusoidal dilatation of the liver in patients on oral contraceptives. Electron microscopical study of 14 cases. Exp Pathol 35:231–237
Balistreri WF, Bove KE (1990) Hepatobiliary consequences of parenteral alimentation. In: Popper H, Schaffner F (eds) Progress in liver disease, vol IX. WB Saunders, Philadephia, pp 567–601
Ballardini G, Fallani M, Biagini G, Bianchi FB, Pisi E (1988) Desmin and actin in the identification of Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis. Virchows Arch B 56:45–49
Bannasch P (1990) Pathobiology of chemical hepatocarcinogenesis: recent progress and perspectives. 1. Cytomorphological changes and cell proliferation. J Gastroenterol Hepatol 5:149–159
Bannasch P, Bloch M, Zerban H (1981) Spongiosis hepatis: specific changes of the perisinusoidal liver cells induced in rats by N-Nitrosomorpholine. Lab Invest 44:252–264
Barcley KL, Yeong ML (1994) Actinomycin D-associated hepatic venoocclusive disease — a report of two cases. Pathology 26:257–260
Barone P, Inferrera C (1969) Pigments in the Dubin-Johnson syndrome. In: Wolman M (ed) Pigments in pathology. Academic Press, New York, pp 307–325
Barthel HR, Hiepe F (1995) Lupus erythematodes und Lebererkrankungen. Dtsch Med Wochenschr 120:1253–1257
Bénichou C (1990) Criteria of drug-induced liver disorders. Report of an International Consensus Meeting. J Hepatol 11:272–276
Berneau J, Mallet L, Benhamou JP (1981) Hepatotoxicite due a la acide tielique. Gastroenterol Clin Biol 5:692–693
Le Bihan G, Bourreille J, Sampson M, Leroy J, Szekely AM, Coquerel A (1980) Fatal hepatic failure and sodium valproate. Lancet 11:1298–1299
Binek J, Hany A, Egloff B, Heer M (1991) Akute todliche Leberinsuffizienz unter Valproinsäuretherapie. Schweiz Med Wochenschr 121:228–233
Bioulac-Sage P, Le Bail B, Bernard PH, Balabaud C (1995) Hepatoportal sclerosis. Semin Liver Dis 15:329–339
Black M, Mitchell JR, Zimmerman HJ, Ishak KG, Epler GR (1975) Isoniacid-associated hepatitis in 124 patients. Gastroenterology 69:289–302
Blake JC, Sawyerr AM, Dooley JS, Scheuer PJ, McIntyre N (1990) Severe hepatitis caused by cyproterone acetate. Gut 31:556–557
Böhles H (1986) Cholestase bei totaler parenteraler Ernahrung (TPE) — eine Übersicht. Klin Paediatr 198:435–441
Bolton JS, Bowen JC (1986) Biliary sclerosis associated with hepatic artery infusion of floxuridine. Surgery 99:119–122
Bourdi M, Larrey D, Nataf J, Berneau J, Pessayre D, Iwasaki M et al. (1990) Anti-liver endoplasmatic reticulum autoantibodies are directed against human cytochrome P450IA2. A specific marker of dihydralazine-induced hepatitis. J Clin Invest 85:1967–1973
Bower RH (1983) Hepatic complications of parenteral nutrition. Semin Liver Dis 3:216–224
Bras G (1973) Aspects of hepatic vascular diseases. In: Gall EA, Mostofi FK (eds) The liver. Williams & Wilkins, Baltimore, pp 406–430
Le Bricquir Y, Larrey D, Blanc P, Pageaux GP, Michel H (1994) Tianeptine — an instance of druginduced hepatotoxicity predicted by prospective experimental studies. J Hepatol 21:771–773
Brouwer A, Hendriks HFJ, Brekelmans P, Buitjenhek M, Knook DL (1986) Lipid analysis of different types of isolated liver cells and their lipid droplets. In: Kirn A, Knook DL, Wisse E (eds) Cells of the hepatic sinusoid, vol 1. Proceedings of the Third International Kupffer Cell Symposium held in Strasbourg, France, 23-27 September, 1985. The Kupffer Cell Foundation, Rijswijk, pp 175–180
Brown RE, Ishak KG (1976) Hepatic zonal degeneration and necrosis in Reye syndrome. Arch Pathol Lab Med 100:123–126
Bruppacher R (1995) Epidemiological identification and evaluation of hepatic adverse drug reactions. Semin Liver Dis 15:301–308
Callea F, Vos RB de, Togni R, Tardanico R, Vanstapel MJ, Desmet VJ (1986) Fibrinogen inclusions in liver cells: a new type of ground-glass hepatocyte. Immune light and electron microscopic characterization. Histopathology 10:65–73
Chang C-H, Uchwat F, Masalskis F, Arcinue EL (1985) Morphologic grading of hepatic mitochondrial alterations in Reye’s syndrome: potential prognostic implication. Pediatr Pathol 4:265–275
Chen KTK, Bocian JJ (1983) Multiple hepatic adenomas. Arch Pathol Lab Med 107:274–275
Clark DW (1985) Genetically determined variability in acetylation and oxidation. Therapeutic implications. Drug 29:342–375
Coates PM, Stanley CA (1992) Inherited disorders of mitochondrial fatty oxidation. In: Boyer JL, Ockner RK (eds) Progress in liver diseases, vol X. WB Saunders, Philadelphia, pp 123–138
Combes B, Whalley PJ, Adams RH (1972) Tetracycline and the liver. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol IV. Grune & Stratton, New York, pp 589–596
Correy L, Rubin RJ, Hattwick MAW, Nolle GR, Cassidy E (1976) A nationwide outbreak of Reye’s syndrome. Its epidemiologic relationship to influenca B. Am J Med 61:615–625
Cortez Pinto H, Baptista A, Camilo ME, de Cowsta EB, Valente A, de Moura MC (1995) Tamoxifenassociated steatohepatitis — report of three cases. J Hepatol 23:95–97
Craig JR, Peters RL, Edmondson HA, Omata M (1980) Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features. Cancer 46:372–379
Craig JR, Peters RL, Edmondson HA (1988) Tumors of the liver and intrahepatic bile ducts. Atlas of tumor pathology, 2nd series, vol 26. Armed Forces Institute of Pathology, Washington
Creagh TM, Rubin A, Evans DJ (1988) Hepatic tumours induced by anabolic steroids in an athlete. J Clin Pathol 41:441–443
Daly AK, Idle JR (1993) Genetics: animal and human cytochrome P450 polymorphism. In: Schenkmann JB, Grain H (eds) Handbook of experimental pharmacology, vol 105. Springer, Berlin Heidelberg New York Tokyo, pp 433–446
Dargel R (1992) Lipid peroxidation — a common pathogenetic mechanism? Exp Toxicol Pathol 44:169–181
Daugherty CC, Gartside PS, Heubi JE, Saalfeld K, Snyder J (1987) A morphometric study of Reye’s syndrome. Correlation of reduced mitochondrial numbers and increased mitochondrial size with clinical manifestations. Am J Pathol 129:313–326
Davis BH, Vucic A (1988) The effects of retinol on Ito cell proliferation in vitro. Hepatology 8:788–793
Degott C, Rueff B, Kreis H, Duboust A, Potet F, Benhamou JP (1978) Peliosis hepatis in recipients of renal transplants. Gut 19:748–753
Dejgaard A, Krogsgaard K, Jacobsen M (1984) Veno-occlusive disease and peliosis of the liver after thorotrast administration. Virchows Arch A 403:87–92
Deleve LD, Kaplowitz N (1990) Importance and regulation of hepatic glutathione. Semin Liver Dis 10:251–266
Del-Val A, Garrigues V, Ponce J, Benages R (1991) Glibenclamideinduced cholestasis. J Hepatol 13:375
Denkhas W, Siebald H (1991) Toxische Leberschadigungen. In: Konietzko J, Dupuis H (Hrsg) Handbuch der Arbeitsmedizin. Arbeitsphysiologie — Arbeitspathologie — Prevention (5. Erg. Lief.). Ecomed, Landsberg/Lech
Desmet VJ (1992) Vanishing bile duct disorders. In: Boyer JL, Ockner RK (eds) Progress in liver diseases, vol X. WB Saunders, Philadelphia, pp 89–121
Dias-Rivera RS, Collago PJ, Pous ER, Torregrosse MV (1950) Acute phosphoric poisoning in man: a study of 56 cases. Medicine 29:269–298
Disney TF, Sullivan SN, Haddard RC, Lowe D, Goldbach MM (1984) Budd-Chiari syndrome with inferior vena cava obstruction associated with systemic lupus erythematosus. J Clin Gastroenterol 6:253–256
Ditzhuijsen TJM van, Haelst UJGM van, Dooren-Grebe RJ van, Kerkhof PCM van de, Yap SH (1990) Severe hepatotoxicity reaction with progression to cirrhosis after use of a novel retinoid (acitretin). J Hepatol 11:185–188
Dölle W, Martini WA (1978) Leber. In: Heintz R (Hrsg) Erkrankungen durch Arzneimittel. Diagnostik, Klinik, Pathogenese, Therapie, 2. Aufl. Thieme, Stuttgart, S 288–329
Doppman JL, Girton ME (1984) Bile duct scarring following ethanol embolization of the hepatic artery: an experimental study in monkeys. Radiology 152:621–626
Dossing M, Arlien-Soborg P, Petersen LM, Ranek L (1983) Liver damage associated with occupational exposure to organic solvents in house painters. Eur J Clin Invest 13:151
Dourakis SP, Alexopoulou AA, Hadziyannis SJ (1994) Fulminant hepatitis after flutamide treatment. J Hepatol 20:350–353
Earnest DL, Brouwer A, Sim WW, Horan MA, Hendriks HFJ, Leeuw AM de, Knook DL (1986) Hypervitaminosis A activates Kupffer cells and lowers the threshold for endotoxin liver injury. In: Kirn A, Knook DL, Wisse E (eds) Cells of the hepatic sinusoid, vol 1. Proceedings of the Third International Kupffer Cell Symposium held in Strasbourg, France, 23-27 September, 1985. The Kupffer Cell Foundation, Rijswijk, pp 277–282
Edmondson HA, Peters RL (1967) Diagnostic problems in liver biopsies. In: Sommers SC (ed) Pathology annual. Butterworth, London, pp 213–242
Edmondson HA, Reynolds TB, Henderson B, Benton B (1977) Regression of liver cell adenomas associated with oral contraceptives. Ann Intern Med 86:180–186
Ehrenforth S, Scharrer I, Herrmann G (1995) Phenoprocoumon-induzierte nekrotisierende Hepatitis. Dtsch Med Wochenschr 120:1529–1530
Enzan H, Himeno H, Iwamura S, Saibara T, Onishi S, Yamamoto Y et al. (1995) Sequential changes in human Ito cells and their relation to postnecrotic liver fibrosis in massive and submassive hepatic necrosis. Virchows Arch 426:95–101
Evans DAP (1986) Acetylation. In: Kadow W, Goedde HW, Agarwal DP (eds) Ethnic differences in reactions of drugs and xenobiotics. Liss, New York, pp 209–242
Falk H, Popper H, Thomas LB, Ishak KG (1979) Hepatic angiosarcoma associated with androgenic-anabolic steroids. Lancet 2:1120–1123
Falk H, Caldwell G, Ishak KG, Thomas IB, Popper H (1981) Arsenic-related angiosarcoma. Am J Ind Med 2:43–50
Fleischner GM, Morecki R, Hanaichi T, Hayashi M, Quintana H, Sternlieb I (1991) Light-and electron-microscopical study of a case of gold salt-induced hepatotoxicity. Hepatology 14:422–425
Forbes GM, Jeffrey GP, Shilkin KB, Reed WD (1992) Carbamazepine hepatotoxicity: another cause of the vanishing bile duct syndrome. Gastroenterology 102:1385–1388
Forns X, Caballeria J, Bruguera M, Salmeron JM, Vilella A, MAs A et al. (1994) Disulfiram-induced hepatitis. Report of four cases and review of the literature. J Hepatol 21:853–857
Fox RA (1979) Immunological basis for toxic liver injury. In: Farber E, Fisher MM (eds) Toxic injury of the liver, part A. Marcel Dekker, New York Basel, pp 193–213
Friefi G, Wienbeck M (1995) Cholestatischer Ikterus nach Einnahme von Amoxicillin und Clavulansaure. Dtsch Med Wochenschr 120:1356–1360
Frimmer M (1976) Mechanismus der Leberschadigung durch Pilzgifte. In: Wannagat L (Hrsg) Toxische Leberschaden. Thieme, Stuttgart, S 137–153
Gaeta GB, Utili R, Tripodi MF (1986) The evaluation of drug hepatotoxicity should include the study of the Kupffer cell function. Comparative effects of Amphotericin B and Ketokonazole on the rat liver. In: Kirn A, Knook DL, Wisse E (eds) Cells of the hepatic sinusoid, vol 1. Proceedings of the Third International Kupffer Cell Symposium held in Strasbourg, France, 23-27 September, 1985. The Kupffer Cell Foundation, Rijswijk, pp 43–44
Gascon MP, Dayer P (1992) Hepatic metabolism of drugs and toxins. In: McIntyre N, Benhamou JP, Bircher J, Rizetto M, Rodes J (eds) Oxford textbook of clinical hepatology. Oxford University Press, Oxford, pp 247–289
Gedigk P, Muller R, Bechtelsheimer H (1974) Morphology of the liver damage among polyvinylchloride production workers. A report on 51 cases. Ann N Y Acad Sci 489:278–285
Gedigk P, Totovic V (1976) Lysosomen und Pigmente. Verh Dtsch Ges Pathol 60:64–94
Geerts A, Vrijsen R, Schellinck P, Wisse E (1989) Retinol affects the phenotype and protein synthesis of fat storing cell-derived myofibroblast in vitro. In: Wisse E, Knook DL, Decker K (eds) Cells of the hepatic sinusoid. Kupffer Cell Foundation, Rijswijk, pp 20–24
Georgiou M, Sianidou L, Hatzis T, Paradatos J, Koutselinis A (1988) Hepatotoxicity due to Atractylis gummifera-L. Clin Toxicol 26:487–493
Gerber MA (1989) Pathology of acute and chronic hepatitis D. In: Seef LB, Lewis JH (eds) Current perspectives in hepatology: Festschrift for Hyman J Zimmerman. Plenum Press, New York, pp 63–70
Gerber N, Dickinson RG, Harland RC, Lynn RK, Houghton D, Antonias JI, Schimschock JC (1979) Reye-like syndrome associated with valproic acid therapy. J Pediatr 95:142–144
Geubel AP, Galoscy C de, Alves N, Rahier J, Dive C (1991) Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases. Gastroenterology 100:1701–1709
Glassberg AB, Rosenbaum EH (1976) Oral contraceptives and malignant hepatoma. Lancet 2:479
Goldin R (1994) Rodent models of alcoholic liver disease. Int J Exp Pathol 75:1–7
Goldstein NS, Kodali VP, Gordon SC (1995) Histologic spectrum of cryptogenic chronic liver disease and comparison with chronic autoimmune and chronic type C hepatitis. Am J Clin Pathol 104:567–573
Goodman ZD (1987) Benign tumours of the liver. In: Okuda K, Ishak KG (eds) Neoplasms of the liver. Springer, Berlin Heidelberg New York Tokyo, pp 105–125
Goodman ZD, Mikel UV, Lubbers PR, Ros PR, Langloss JM, Ishak KG (1987) Kupffer cells in hepatocellular adenomas. Am J Surg Pathol 11:191–196
Guengerich FP (1989) Polymorphismus of cytochrome P450 in humans. TIPS 10:107–109
Haemmerli UP (1966) Jaundice during pregnancy. With special emphasis on recurrent jaundice during pregnancy and its differential diagnosis. Springer, Berlin Heidelberg New York
Haemmerli UP, Wyss HI (1967) Recurrent intrahepatic cholestasis of pregnancy: report of six cases and review of the literature. Medicine 46:299–321
Hirsch D, Bernheim J, Kovatz S, Shenkman L (1994) Fatal fulminant hepatitis from cyproterone acetate. Isr J Med Sci 30:238–240
Hohler T, Schnütgen M, Helmreich-Becker I, Mayet WJ, Meyer zum Büschenfelde K-H (1994) Drug-induced hepatitis: a rare complication of oral anticoagulants. J Hepatol 21:447–449
Hoof F van, Hageman-Bal M (1967) Progressive familial myoclonic epilepsy with Lafora bodies — electronmicroscopic and histochemical study of a cerebral biopsy. Acta Neuropathol 7:315–326
Horn T, Junge J, Christoffersen P (1986) Early alcoholic liver injury: activation of lipocytes in acinar zone 3 and correlation to the degrees of collagen formation in the Disse space. J Hepatol 3:333–340
Horst DA, Grace ND, LeComple PM (1980) Prolonged cholestasis and progressive hepatic fibrosis following imipramime therapy. Gastroenterology 79:550–554
Hruban Z, Slesers A, Hopkins E (1972) Drug-induced and naturally occuring myelin bodies. Lab Invest 27:62–70
Huchzermeyer H, Münzenmaier R (1995) Lovastatin-induzierte akute cholestatische Hepatitis. Dtsch Med Wochenschr 120:252–256
Iseri OA, Gottlieb LS (1971) Alcoholic hyalin and megamitochondria as separate and distinct entities in liver disease associated with alcoholism. Gastroenterology 60:1027–1035
Ishak KG (1979) Hepatic neoplasmas associated with contraceptive and anabolic steroids. In: Lingeman CH (ed) Carcinogenic hormones. Springer, Berlin Heidelberg New York, pp 73–128
Ishak KG (1981) Hepatic lesions caused by anabolic and contraceptive steroids. Semin Liver Dis 1:116–128
Ishak KG, Irey NS (1972) Hepatic injury associated withe the phenothiazines. Clinico-pathologic and follow-up study of 36 patients. Arch Pathol 93:283–304
Ishak KG, Zimmerman HJ (1988) Drug-induced and toxic granulomatous hepatitis. Baillieres Clin Gastroenterol 2:463–480
Jezequel AM (1976) Ultrastructural changes induced by drugs. In: Taylor W (ed) The hepatobiliary system. Fundamental and pathological mechanism. Plenum Press, New York London, pp 179–200
Jones JK, Carr SW van de, Zimmerman H, Leroy A (1983) Heptotoxicity associated with phenothiazines. Psychopharmacol Bull 19:24–27
Kalantzis N, Gabriel P, Mouzas J, Tiniakos D, Tsigas D, Tiniakos G (1991) Acute amiodaroneinduced hepatitis. Hepatogastrotenterology. 38:71–74
Kamm MA, Davies DJ, Breen KJ (1988) Acute hepatitis due to etretinate. J Gastroenterol Hepatol 3:633–666
Kane JA, Kane SP, Jain S (1995) Hepatitis induced by traditional Chinese herbs; possible toxic components. Gut 36:146–147
Kaneda K, Dan C, Wake K (1986) “Giant vacuoles” formed in Kupffer cells after the latex particle injection. Inn: Kirn A, Knook DL, Wisse E (eds) Cells of the hepatic sinusoid, vol 1. Proceedings of the Third International Kupffer Cell Symposium held in Strasbourg, France, 23-27 September, 1985. The Kupffer Cell Foundation, Rijswijk, pp 163–164
Keiding S (1995) Drug administration to liver patients: aspects of liver pathophysiology. Semin Liver Dis 15:268–282
Kenna JG, Neuberger J, Williams R (1988) Evidence for expression in human liver of halothaneinduced neoantigens recognized by antibodies in sera from patients with halothane hepatitis. Hepatology 8:1635–1641
Kenna JG, Pelt FNAM van (1994) The metabolism and toxicity of inhaled anaesthetic agents. Anaesth Pharmacol Rev 2:29–42
Khedun SM, Maharaj B, Leary WP (1992) The effects of supra-therapeutic doses of rifampicin on liver function in the perfused rat liver. Int J Exp Pathol 73:449–453
Kiessling K-H, Pilstr6m L (1971) Ethanol and the human liver. Structural and metabolic changes in liver mitochondria. Cytobiologie 4:339–348
King PD, Blitzer BL (1990) Drug-induced cholestasis: pathogenesis and clinical features. Semin Liver Dis 10:316–338
Klatskin G (1977) Hepatic tumours: possible relationship to use of oral contraceptives. Gastroenterology 73:386–394
Klauw MM van der, Houtman PM, Stricker BHC, Spoelstra P (1994) Hepatic injury caused by benzbromarone. J Hepatol 20:376–379
Klein S, Nealon WH (1988) Hepatobiliary abnormalities associated with total parenteral nutrition. Semin Liver Dis 8:237–246
Klinge O (1973a) Kernveränderungen und Kernteilungsstörungen in der Altersleber. Gerontologica 19:314–339
Klinge O (1973b) Cytologic and histologic aspects of toxically induced liver reactions. Curr Top Pathol 58:91–116
Klinge O (1974) Chronische toxische Hepatosen und ihre morphologischen Beziehungen zur chronischen Hepatitis. In: Wannagat L (Hrsg) Chronische Hepatitis — Zirrhosen. Thieme, Stuttgart, S 31–41
Klinge O (1976) Agranulares endoplasmatisches Retikulum — die strukturelle Grundlage der Biotransformation in der Leber. In: Wannagat L (Hrsg) Toxische Leberschäden. Thieme, Stuttgart, S 21–33
Klinge O (1995) Intrahepatische Cholangitis auf vermutlich immunologischer Grundlage. Verh Dtsch Ges Pathol 79:198–232
Klinge O, Altmann H-W (1971) Morphologie toxischer Hepatosen. Münch Med Wochenschr 113:1529–1539
Klinge O, Altmann H-W (1973) Punktathistologie drogenbedingter Leberreaktionen. In: Kühn HA, Markoff NG, Meier MS (Hrsg) Aktuelle Hepatologie. Thieme, Stuttgart, S 8–22
Klinge O, Pfeifer U (1979) Pigmentablagerungen in der Leber. In: Kühn HA, Wernze H (Hrsg) Klinische Hepatologie. Thieme, Stuttgart, S 1.43–1.52
Klinge O, Ross W, Struder E (1975) Das Karyogramm normaler und verfetteter Lebern des Menschen. Virchows Arch A 366:203–222
Knolle J, Förster E, Roessner A, Themann H, Hohn P, Meyer zum Büschenfelde K-H (1974) Die nicht-zirrhotische portale Fibrose (hepatoportale Sklerose) nach chronischer Arsenvergiftung. Dtsch Med Wochenschr 99:903–908
Knowles II BM, Wolff MW (1976) Focal nodular hyperplasia of the liver: a clinicopathologic study and review of the literature. Hum Pathol 7:533–545
Koelma IA, Nap M, Hitema S, Krom RAF, Houthoff HJ (1986) Hepatocellular carcinoma, adenoma, and focal nodular hyperplasia comparative histopathologic study with immunohistochemical parameters. Arch Pathol Lab Med 110:1035–1040
Kohn N, Myerson RM (1961) Xanthomatous biliary cirrhosis following chlorpromazine. Am J Med 31:665–670
Kowalski TE, Falestini M, Furth E, Malet PF (1994) Vitamin A hepatotoxicitiy: a cautionary note regarding 25,000 IU supplements. Am J Med 97:523–528
Küpfer A, Preisig R (1983) Inherited defects of hepatic drug metabolism. Semin Liver Dis 3:341–354
Kunelis CT, Peters JL, Edmondson HA (1965) Fatty liver of pregnancy and its relationship to Tetracycline therapy. Am J Med 38:359–377
Landas SK, Mitros FA, Furst DE, LaBreque DR (1992) Lipogranulomas and gold in the liver in rheumatoid arthritis. Am J Surg Pathol 16:171–174
Larrey D, Pageaux GP (1995) Hepatotoxicity of herbal remedies and mushrooms. Semin Liver Dis 15:183–188
Laskin DL (1990) Nonparenchymal cells and hepatotoxicity. Semin Liver Dis 10:293–304
Lepper MH, Wolfe CK, Zimmerman HJ, Caldwell ER, Spies HW, Dowling HF (1953) Effects of large doses of aureomycin on human liver. Arch Intern Med 88:271–283
Levy M, Goodman MW, van Dyke BJ, Summer HW (1981) Granulomatous hepatitis secondary to carbamazepine. Ann Intern Med 95:64–65
Lewin K, Millis RR (1973) Human radiation hepatitis. A morphologic study with emphasis on the late stages. Arch Pathol 96:21–26
Lewis JH, Zimmerman HJ, Benson GD, Ishak KG (1984) Hepatic injury associated with Katoconazol therapy. Analysis of 33 cases. Gastroenterology 86:503–513
Lewis JH, Mullick FG, Ishak KG, Ranard RC, Ragsdale B, Perse RM et al. (1990) Histopathologic analysis of suspected amiodarone hepatotoxicity. Hum Pathol 21:59–67
Lewis O, Wainwright HC, KEW HC; Zwi S, Isaacson C (1979) Liver damage associated with perhexiline maleate. Gut 20:186–189
Lindner H, Weber D, Kloppel G (1976) Prajmaliumbitartrat-induzierte Leberschaden. Dtsch Med Wochenschr 101:1876–1880
Linthoudt D van, Buss W, Beyner F, Ott H (1991) Nécrose hépatique fatale au cours d’un traitement aux sels d’or d’une polyarthrite rhumatoide. Schweiz Med Wochenschr 121:1099–1102
Loomus GN, Aneja P, Bota RA (1983) A case of peliosis hepatis in association with tamoxifentherapy. Am J Clin Pathol 80:881–883
Luca LM de, Creek KE (1986) Vitamin A and the liver. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol VIII. Grune & Stratton, Orlando, pp 81–98
Ludwig J, Axelsen R (1983) Drug effects on the liver. An updated compilation of drugs and drugrelated hepatic diseases. Dig Dis Sci 28:651–666
Ludwig J, Viggiano TR, McGill DB, Ott BJ (1980) Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hiterto unnamed disease. Mayo Clin Proc 55:434–438
Ludwig J, Kim CH, Wiesner RH, Krom RA (1989) Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy? Hepatology 9:215–218
Ludwig J, Hashimoto E, Obata H, Baldus WP (1993) Idiopathic portal hypertension: a histopathological study of 26 Japanese cases. Histopathology 22:227–234
Lüders CJ, Riske WEO, Henning H, Vogel H-M (1975) Die Histomorphologie der Leber bei Schadigung mit phenolisatinhaltigen Laxantien (rezidivierende chronische Cholangiohepatitis). Virchows Arch A 365:309–325
Lüllmann H, Lüllmann-Rauch R, Wasserman O (1975) Drug induced phospholipidosis. Crit Rev Toxicol 4:185–218
Lukomska B, Pienkowska B, Andrzejewski W, Olszewski WL (1991) Liver sinusoidal cytotoxic cells are recruited from blood and divide locally. J Hepatol 12:332–335
Maddrey WC, Boitnott JK (1975) Severe hepatitis from methyldopa. Gastroenterology 68:351–360
Maddrey WC, Boitnott JK (1979) Drug-induced chronic hepatitis and cirrhosis. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol VI. Grune & Stratton, New York, pp 595–603
Mallat A, Dhumeaux D (1991) Cocaine and the liver. J Hepatol 12:275–278
Marzabadi MR, Sohal RS, Brunk UT (1991) Mechanisms of lipofuscinogenesis: effect of the inhibition of lysosomal proteinases and lipases under varying concentrations of ambient oxygen in cultured rat neonatal myocardial cells. APMIS 99:416–426
Mason A, Sallie R (1995) What causes fulminant hepatic failure of unknown etiology? Am J Clin Pathol 104:491–494
Mathew J, Hines JE, James OFW, Burt AD (1994) Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. J Hepatol 20:537–541
Matsumoto T, Yoshimine T, Shimouchi K, Shiotu H, Kuwabara N, Fukuda Y, Hoshi T (1992) The liver in systemic lupus erythematosus: pathologic analysis of 52 cases and review of Japanese autopsy registry date. Hum Pathol 23:1151–1158
Mays ET, Christopherson W (1984) Hepatic tumors induced by sex steroids. Semin Liver Dis 4:147–157
McCaughan GW, Bilous MJ, Gallagher ND (1985) Long-term survival with tumor regression in androgen-induced liver tumors. Cancer 56:2622–2626
McDonald GB, Tirumali N (1984) Intestinal and liver toxicity of neoplastic drugs. West J Med 140:250–259
McMaster KR, Hennigar GR (1981) Drug-induced granulomatous hepatitis. Lab Invest 44: 61–73
Meijer DKF, Molema G (1995) Targeting of drugs to the liver. Semin Liver Dis 15:202–256
Meyer UA, Zanger UM, Skoda RC, Grant D, Blum M (1990) Genetic polymorphism of drug metabolism. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol IX. Grune & Stratton, New York, pp 307–323
Meyler’s side effects of drugs (1996/1997), vol 13. Elsevier, Amsterdam New York Oxford
Miller EC, Miller JA (1976) Hepatocarcinogenesis by chemicals. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol V. Grune & Stratton, New York, pp 699–711
Mölleken K (1979) Liver biopsy findings after intake of oral contraceptives. Zentralbl Allg Pathol 123:195–201
Morris JS, Schmid M, Newman S, Scheuer PJ, Sherlock S (1974) Arsenic and non cirrhotic portal hypertension. Gastroenterology 66:86–94
Moss RL, DAS JB, Raffensperger JG (1993) Total parenteral nutrition-associated cholestasis: clinical and histopathologic correlation. J Pediatr Surg 28:1270–1275
Myers MG (1982) Hepatic cellular injury during varicella. Arch Dis Child 57:317–319
Myers JL, Augur Jr NA (1984) Hydralazine-induced cholangitis. Gastroenterology 87:1185–1188
Nadell J, Kosek J (1977) Peliosis hepatis. Twelve cases associated with oral androgen therapy.Arch Pathol Lab Med 101:405–410
Nakamura H, Uehara H, Okada T, Kambe H, Kimura Y, Ito H et al. (1989) Occlusion of small hepatic veins associated with systemic lupus erythematosus with the lupus anticoagulant and anti-cardiolipin antibody. Hepatogastroenterology 36:393–397
Nakashima O, Sugihara S, Eguchi A, Taguchi J, Watanabe J, Kojiro M (1992) Pathomorphologic study of pale bodies in hepatocellular carcinoma. Acta Pathol Jpn 42:414–418
Nebert DW, McKinnon RA (1994) Cytochrome P450: evolution and functional diversity. In: Boyer JL, Ockner RK (eds) Progress in liver diseases, vol XII. WB Saunders, Philadelphia, pp 63–97
Nelson SD (1990) Molecular mechanism of the hepatotoxicity caused by acetaminophen. Semin Liver Dis 10:267–278
Neuberger J, Kenna JG, Aria KN, Williams R (1985) Antibody mediated hepatocyte injury in methyldopa-induced hepatotoxicity. Gut 26:1233–1239
Nohlgard C, Rubio CA, Kock Y, Hammar H (1993) Liver fibrosis quantified by image analysis in methotrexate-treated patients with psoriasis. J Am Acad Dermatol 28:40–45
Oldershausen H-F von (1968) Schwangerschaftsikterus und ovulationshemmende Steroide. Dtsch Med J 19:394–403
Olsson R, Wiholm B-E, Sand C, Zettergren L, Hultcrantz R, Myrhed M (1992) Liver damage from flucloxacillin, cloxacillin and dicloxacillin. J Hepatol 15:154–161
Ortega L, Landa Garcia JI, Torres Garcia A, Silecchia G, Arenas J, Suarez A et al. (1985) Acetaminophen-induced fulminant hepatic failure in dogs. Hepatology 5:673–676
Osterloh J, Cunningham W, Dixon A, Combest D (1989) Biochemical relationships between Reye’s and Reye’s-like metabolic and toxicological syndromes. Med Toxicol Adverse Drug Exp 4:272–294
Partin JC, Schubert WK, Partin JS (1971) Mitochondrial ultrastructure in Reye’s syndrome (encephalopathy and fatty degeneration of the viscera). N Engl J Med 285:1339–1349
Partin JS, Daugherty CC, McAdams AJ, Partin JC, Schubert WK (1984) A comparison of liver ultrastructure in salicylate intoxication and Reye’s syndrome. Hepatology 4:687–690
Passo B, Harrison DC (1975) A new look at an old problem: mushroom poisoning. Am J Med 58:505–509
Paulini K, Beneke G, Kulka R (1971) Der Mechanismus der Lebervergrofierung nach verschieden hoher Phenobarbitaldosis. Beitr Pathol 143:283–294
Pelt FNAM van, Straub P, Manns MP (1995) Molecular basis of drug-induced immunological liver injury. Semin Liver Dis 15:283–300
Perez V, Schaffner F, Popper H (1972) Hepatic drug reaction. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol 4. Grune & Stratton, New York, pp 597–625
Perharic-Walton L, Murray V (1992) Toxicity of Chinese herbal remedies. Lancet 340:674
Pessayre D (1992) Drug-induced liver disease. In: Prieto J, Rodes J, Shafritz DA (eds) Hepatobiliary diseases. Spinger, Berlin Heidelberg New York Tokyo, pp 697–727
Pessayre D (1995) Role of reactive metabolites in drug-induced hepatitis. J Hepatol 23 (Suppl 1):16–24
Pessayre D, Bichara M, Feldmann G, Degott C, Patet F, Benhamou JP (1979) Perhexiline maleateinduced cirrhosis. Gastroenterology 76:170–177
Pessayre D, Larrey D (1988) Acute and chronic drug-induced hepatitis. Baillieres Clin Gastroenterol 2:385–422
Peters RL (1977) Patterns of hepatic morphology in jejunoileal bypass patients. Am J Clin Nutr 30:53–57
Peters RL, Edmondson HA, Mikkelsen W, Tatter D (1967) Tetracycline induced fatty liver in non-pregnant patients. Am J Surg 113:622–632
Pfeifer U (1976) Lysosomen und Autophagic Verh Dtsch Ges Pathol 60:28–64
Phillips MJ, Oda M, Funatsu K (1978) Evidence of microfilament involvement in norethendrolone-induced intrahepatic cholestasis. Am J Pathol 93:729–744
Pimentel JC, Menezes AP (1977) Liver disease in vineyard sprayers. Gastroenterology 71:275–283
Pohl LR (1990) Drug-induced allergic hepatitis. Semin Liver Dis 10:305–315
Pohl LR, Kenna JG, Satoh H, Christ D, Martin JL (1989) Neoantigens associated with halothane hepatitis. Drug Metab Rev 20:203–217
Popper H, Rubin E, Gardiol D, Schaffner F, Paronetto F (1965) Drug-induced liver disease: penalty for progress. Arch Intern Med 115:125–136
Poucell S, Ireton J, Valencia-Mayoral P, Downar E, Larratt L, Patterson J et al. (1984) Amiodarone-associated phospholipidosis and fibrosis of the liver. Light, immunohistochemical, and electron microscopic studies. Gastroenterology 86:926–936
Poupon R, Rosensztajn L, Prudhomme de Saint-Maur P, Lageron A, Gombeau T, Darnis F (1980) Perhexiline maleate-associated hepatic injury prevalence and characteristics. Digestion 20:145–150
Powell CJ, Charles SJ, Mullervy J (1994) Cocaine hepatotoxicity: a study on the pathogenesis of periportal necrosis. Int J Exp Pathol 75:415–424
Price Evans DAP, Manley KA, McKusick VA (1960) Genetic control of isoniazid metabolism in man. Br Med J 2:485–491
Quigley EMM, Zetterman RK (1988) Hepatobiliary complications of malabsorption and malnutrition. Semin Liver Dis 8:218–228
Rao MS, Subbaro V, Yeldandi AV, Reddy JK (1992) Hepatocarcinogenicity of dehydroepiandrosterone in the rat. Cancer Res 52:2977–2979
Redlich CA, West AB, Fleming L, True LD, Cullen MR, Riely CA (1990) Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylformamide. Gastroenterology 99:748–757
Reed GB jr, Cox AJ jr (1966) The human liver after radiation injury. A form of veno-occlusive disease. Am J Pathol 48:597–611
Reichen J (1995) Assessment of hepatic function with xenobiotics. Semin Liver Dis 15:189–201
Reinl W, Urban HJ (1965) Erkrankungen durch Dimethylformamid. Int Arch Gewerbepathol Gewerbehyg 21:333–346
Remington PL, Rowley D, McGee H, Hall WN, Monto AS (1986) Decreasing trends in Reye syndrome and aspirin use in Michigan, 1979 to 1984. Pediatrics 77:93–98
Remmer H (1969) Die Entgiftungsfunktion der Leber. In: Kühn HA, Liehr H (Hrsg) Aktuelle Hepatologie. Thieme, Stuttgart, S 98–108
Remmer H, Merker H-J (1963) Enzyminduktion und Vermehrung von endoplasmatischem Retikulum in der Leberzelle wahrend der Behandlung mit Phenobarbital (Luminal). Klin Wochenschr 41:276–283
Reynolds TB (1975) Laxative liver disease. In: Gerok W, Sickinger K (eds) Drugs and the liver. Schattauer, Stuttgart New York, pp 319–325
Riely CA (1988) Case studies in jaundice of pregnancy. Semin Liver Dis 8:191–199
Rio B, Cahn JY, Attal M, Drouet L, Scrobohaci ML, Degos F et al. (1994) Hepatic venoocclusive disease following bone marrow transplantation. Proceedings of a symposium of FAG and GEGMO groups. Presse Med 23:1217–1222
Rössle R (1929) Hepatose und Hepatitis. Schweiz Med Wochenschr 59:4–9
Rolfes DB, Ishak KG (1985) Acute fatty liver of pregnancy: a clinicopathologic study of 35 cases. Hepatology 5:1149–1157
Rolfes DB, Ishak KG (1986) Liver disease in pregnancy. Histopathology 10:555–570
Roschlau G (1983) Hepatitis mit konfluierenden Nekrosen durch Dihydralazin (Depressan). Eine klinisch-pathologische Studie an Hand von 20 Fallen. Zentralbl Allg Pathol 127:385–393
Roth F (1956) Über die chronische Arsenvergiftung der Moselwinzer unter besonderer Berücksichtigung des Arsenkrebses. Z Krebsforsch 61:287–319
Roth F (1957) Arsen-Leber-Tumoren (Haemangioendotheliom) Z Krebsforsch 62:468–503
Ruben FL (1991) Reye syndrome. In: Belshe RB (ed) Textbook of human virology, 2nd edn. Mosby Year Book, St. Louis, pp 1033–1043
Rubin E, Beattie DS, Lieber CS (1970) Effect of ethanol on the biogenesis of mitochondrial membranes and associated mitochondrial functions. Lab Invest 23:620–627
Rubin E, Florman AL, Degnan T, Diaz J (1970) Hepatic injury in chronic hypervitaminosis A. Am J Dis Child 119:132–138
Ruebner BH, Montgomery CK, French SW (1991) Diagnostic pathology of the liver and biliary tract: Fatty liver. Hemisphere, New York, pp 141–154
Saez-Royuela F, Lopez-Vasquez A, Lopez-Moranta A (1995) Pentoxifylline-induced acute hepatitis. J Hepatol 23:482–483
Saibara T, Himeno H, Ueda H, Onishi S, Yamamoto Y, Enzan H et al. (1994) Acute hepatic failure with swollen mitochondria and microvesicular fatty degeneration of hepatocytes triggered by free radical initiator. Lab Invest 70:517–524
Salete Trigueiro de Araujo M, Gerard F, Chossegros P, Christovao Porto L, Barlet P, Grimaud J-A (1990) Vascular hepatotoxicity related to heroin addiction. Virchows Arch A 417:497–503
Salete Trigueiro de Araujo M, Gerard F, Chossegros P, Guerret S, Grimaud J-A (1992) Lack of hepatocyte involvement in the genesis of the sinusoidal dilatation related to heroin addiction: a morphometric study. Virchows Arch A 420:149–153
Samuels AM, Carey MC (1978) Effects of chlorpromazine hydrochloride and its metabolites on Mg2+-and Na+, K+-ATPase activities of canalicular-enriched rat liver plasma membranes. Gastroenterology 74:1183–1190
Sanchez-Lanier M, Davis LE, Blisard KS, Woodfin BM, Wallace JM, Caskey LS (1991) Influenza A virus in the mouse: hepatic and cerebral lesions in a ReyeVsyndrome-like illnes. Int J Exp Pathol 72:489–500
Sarachek NS, London RL, Matulewicz TC (1985) Diltiazem and granulomatous hepatitis. Gastroenterology 88:1260–1262
Schaffner F, Thaler H (1986) Nonalcoholic fatty liver disease. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol VIII. Grune & Stratton, New York, pp 283–298
Schapira D, Bassan L, Nahir AM, Scharf Y (1986) Diclofenac-induced hepatotoxicity. Postgrad Med J 62:63–65
Schenker B, Breen KJ, Heimberg M (1976) Pathogenesis of tetracycline-induced fatty liver. In: Gerok W, Sickinger K (eds) Drugs and the liver. Schattauer, Stuttgart New York, pp 269–280
Scheuer PJ (1980) Liver biopsy interpretation 3rd edn. Williams & Wilkins, Baltimore, pp 88–101
Scheuer PJ, Ashrafzadeh P, Sherlock S, Brown D, Dusheiko GM (1992) The pathology of hepatitis C. Hepatology 15:567–571
Schochel SS jr, McCormick WF, Zellweger H (1970) Type IV glycogenosis (amylopectinosis). Light and electron microscopic observations. Arch Pathol 90:354–363
Schulte-Hermann R (1973) Induction of liver growth by xenobiotic compounds and other stimuli. Crit Rev Toxicol 3:97–158
Schumacher K (1970) Immunpathologische Phanomene bei chronischer Hepatitis. Internist 11:11–17
Seeff LB (1981) Drug-induced chronic liver disease, with emphasis on chronic active hepatitis. Semin Liver Dis 1:104–115
Seidegard J, Vorachek WR, Pero RW, Pearson RW (1988) Hereditary differences in the expression of human glutathion transferase activity on transstilbene oxide are due to a gene deletion. Proc Natl Acad Sci USA 85:7293–7297
Seifert WF, Roholl PJM, Blauw B, Ham F van der, Thiel van, Ruiter CF de, Seifert-Bock I et al. (1994) Fat-storing cells and myofibroblasts are involved in the initial phase of carbon tetrachloride-induced hepatic fibrosis in BN/BiRij rats. Int J Exp Pathol 75:131–146
Sharp JR, Ishak KG, Zimmerman HJ (1980) Chronic active hepatitis and severe hepatic necrosis associated with nitrofurantoin. Ann Intern Med 92:14–19
Shaw GR, Anderson WR (1991) Multisystem failure and hepatic microvesicular fatty metamorphosis associated with Tolmetin ingestion. Arch Pathol Lab Med 115:818–821
Shear NH, Spielberg SP (1988) Anticonvulsant hypersensitivity syndrome: in vitro assessment of risk. J Clin Invest 82:1826–1832
Shibayama Y, Asaka S, Nakata K (1993) Augmentation of endotoxin hepatotoxicity by zinc. Exp Toxicol Pathol 45:351–354
Side effects of drugs annual (1977-1994) Dukes MNG (ed): vol 1-15, Aronson JK, Boxtel CJ van (eds) vol 16-18
Silva MO, Roth D, Reddy R, Fernandez JA, Albores-Saavedra J, Schiff ER (1991) Hepatic dysfunction accompanying acute cocaine intoxication. J Hepatol 12:312–315
Silverman JA, Thorgeirsson SS (1995) Regulation and function of the multidrug resistance genes in the liver. In: Boyer JL, Ockner RK (eds) Progress in liver diseases, vol XIII. Saunders, Philadelphia, pp 101–123
Simon JB, Manley PN, Brien JF, Armstrong PW (1984) Amiodarone hepatotoxicity simulating alcoholic liver disease. N Engl J Med 311:167–172
Smetana HF (1963) The histopathology of drug-induced liver disease. Ann NY Acad Sci 104:821–846
Sotaniemi EA, Sutinen S, Sutinen S, Arranto AJ, Pelkonen RO (1982) Liver injury in subjects occupationally exposed to chemicals. Acta Med Scand 212:207–215
Speck RF, Schranz C, Lauterburg BH (1993) Prednisolone stimulates glutathione synthesis in mice. Protection by prednisolone against acetaminophen hepatotoxicity in vivo. J Hepatol 18:62–67
Spreckelsen U, Kirchhoff R, Haacke H (1991) Cholestatischer Ikterus während Lovastatin-Einnahme. Dtsch Med Wochenschr 116:739–740
Stenger RJ (1970) Organelle pathology of the liver. The endoplasmic reticulum. Gastroenterology 58:554–574
Stenwig AE, Solgaard T (1975) Ruptured benign hepatoma associated with an oral contraceptive. A case report. Virchows Arch A 367:337–343
Stricker BHC (1992) Drug-induced hepatic injury, 2nd edn. Elsevier, Amsterdam
Stricker BHC, Spoelstra P (1985) Drug induced hepatic injury. Elsevier, Amsterdam
Stromeyer FW, Ishak KG, Gerber MA, Mathew T (1980) Ground-glass cells in hepatocellular carcinoma. Am J Clin Pathol 74:254–258
Swank LA, Chajfer G, Namchansky BA (1978) Allopurinol-induced granulomatous hepatitis with cholangitis and a sarcoid-like reaction. Arch Intern Med 138:997–998
Stuart KL, Bras G (1957) Veno-occlusive disease of the liver. Q J Med 26:291–315
Tabuenca JM (1981) Toxic-allergic syndrome caused by ingestion of rapeseed oil denatured with Anilin. Lancet II: 567–568
Tao LC (1991) Oral contraceptive-associated liver cell adenoma and hepatocellular carcinoma: cytomorphology and mechanism of malignant transformation. Cancer 68:341–347
Terada T, Nakanuma Y (1995) Arterial elements and perisinusoidal cells in borderline hepatocellular nodules and small hepatocellular carcinomas. Histopathology 27:333–339
Tesluk H, Lawrie J (1981) Hepatocellular adenoma. Its transformation to carcinoma in a user of oral contraceptives. Arch Pathol 105:296–299
Thompson O, Reinicke V (1981) Grund glass inclusions in liver cells in an alcoholic treated with cyanamide (Dipsan). Liver 1:67–73
Toft E, Vyberg M, Therkelsen K (1991) Diltiazem-induced granulomatous hepatitis. Histopathology 18:474–475
Touraine RL, Bertrand Y, Foray P, Gilly J, Philippe N (1993) Hepatic tumours during androgen therapy in Fanconi’s anaemia. Eur J Pediatr 152:691–693
Tran A, Housset C, Boboc B, Tourani J-M, Carnot F, Berthelot P (1991) Etoposide (VP 16-213) induced hepatitis. Report of three cases following standard-dose treatments. J Hepatol 12:36–39
Trigueiro de Araujo MS, Gerard F, Chossegros P, Guerret S, Barlet P, Adeleine P, Grimaud J-A (1993) Cellular and matrix changes in drug abuser liver sinusoids: a semiquantitative and morphometric ultrastructural study. Virchows Arch A 422:145–152
Valla D, Casadevall N, Lacombe C, Varet B, Goldwasser E, Franco D et al. (1985) Primary myeoloproliferative disorder and hepatic vein thrombosis. A prospective study of erythroid colony formation in vitro in 20 patients with Budd-Chiari syndrome. Ann Intern Med 103:329–334
Valla D, Le MG, Poynard T, Zucman N, Rueff B, Benhamou J-P (1986) Risk of hepatic vein thrombosis in relation to recent use of oral contraceptives. A case-control study. Gastroenterology 90:807–811
Varner M, Rinderknecht NK (1980) Acute fatty metamorphosis of the liver in pregnancy. A maternal mortality and literature review. J Reprod Med 24:177–180
Vazquez JJ, Pardo-Mindan J (1979) Liver cell injury (bodies similar to Lafora’s) in alcoholics treated with disulfiram (Antabuse). Histopathology 3:377–384
Vergani D, Mieli-Vergani G, Alberti A, Neuberger J, Eddleston ALWF, Davies M, Williams R (1980) Antibodies to the surface of halo thane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis. N Engl J Med 303:66–71
Vessey DA (1990) Metabolism of drugs and toxins by human liver. In: Zakim D, Boyer TD (eds) Hepatology. A textbook of liver disease, vol 1, 2nd edn. Saunders, Philadelphia, pp 196–234
Vierling JM (1990a) Hepatobiliary complications of ulcerative colitis and Crohn’s disease. In: Zakim D, Boyer TD (eds) Hepatology. A textbook of liver disease, 2nd edn. Saunders, Philadelphia, pp 1126–1158
Vierling JM (1990b) Primary biliary cirrhosis. In: Zakim D, Boyer TD (eds) Hepatology. A textbook of liver disease, 2nd edn. Saunders, Philadelphia, pp 1158–1205
Villari D, Rubino F, Corica F, Spinella S, Cesare E di, Longo G, Raimondo G (1995) Bile duct ductopenia following therapy with sulpiride. Virchows Arch 427:223–226
Wanless IR (1990) Micronodular transformation (nodular regenerative hyperplasia) of the liver: a report of 64 cases among 2500 autopsies and a new classification of benign hepatocellular nodules. Hepatology 11:787–797
Wanless IR, Geddie WR (1985) Mineral oil lipogranulomata in liver and spleen. A study of 465 autopsies. Arch Pathol Lab Med 109:283–286
Wanless IR, Dore S, Gopinath N, Tan J, Cameron R, Heathcote EJ et al. (1990) Histopathology of cocaine hepatotoxicity. Report of four patients. Gastroenterology 98:497–501
Watkins PB (1990) Role of cytochromes P450 in drug metabolism and hepatotoxicity. Semin Liver Dis 10:235–250
Weber TR, Gross KR, Grosfeld JL (1983) Intrahepatic cholestasis and endotoxemia: implications for liver disease related to total parenteral nutrition. In: Kasai M (ed) Biliary atresia and its related disorders. Proceedings of an Internation Symposium, Sendai, Japan. Excerpta Medica, Amsterdam, pp 31–37
Weber WW (1987) The acetylator genes and drug response. Oxford University Press, New York
Wepler W (1971) Morphologie chronischer Leberkrankheiten. Leber Magen Darm 1:45–50
Westphal SA (1994) Hepatotoxicity from propylthiouracil. South Med J 87:943–947
Westphal T (1972) Struktur und Wirkung der Amatoxine. Naturwissenschaften 59:225–231
Williams AT, Burk RF (1990) Carbon tetrachloride hepatotoxicity: an example of free radicalmediated injury. Semin Liver Dis 10:279–284
Williamson J, Chopin J (1980) Adverse reactions to prescribed drugs in the elderly: a multicenter investigation. Age Ageing 9:73–80
Woolley S, Burger HR, Zellweger U (1990) Phenprocoumon-induzierte cholestatische Hepatitis. Dtsch Med Wochenschr 120:1507–1510
Wout JW van’t, Herrmann WA, Vries RA de, Stricker BHC (1994) Terbinafine-associated hepatic injury. J Hepatol 21:115–117
Wright R (1981) Drug-induced chronic hepatitis. Springer Semin Immunopathol 3:331–338
Yanoff M, Rawson AJ (1964) Peliosis hepatis. An anatomical study with demonstration of two varieties. Arch Pathol 77:159–165
Zafrani ES, Berthelot P (1982) Sodium valporate in the induction of unusual hepatotoxicity. Hepatology 2:648–649
Zafrani ES, Ishak KG, Rudzki C (1979) Cholestatic hepatocellular injury associated with erythromycin esters. Report of nine cases. Dig Dis Sci 24:385–396
Zafrani ES, Pinaudeau Y, Dhumeaux D (1983) Drug induced vascular lesions of the liver. Arch Intern Med 143:495–502
Zafrani ES, Bernuau D, Feldmann G (1984) Peliosis-like ultrastructural changes of the hepatic sinusoids in human chronic hypervitaminosis A. Hum Pathol 15:1166–1170
Zala G, Schmid M, Bühler H (1993) Fulminante Hepatitis durch Disulfiram. Dtsch Med Wochenschr 118:1355–1360
Zimmerman HJ (1978) Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. Appleton Century Crofts, New York
Zimmerman HJ (1986) Hepatotoxic effects of oncotherapeutic agents. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol VIII. Grune & Stratton, Orlando, pp 621–642
Zimmermann H, Eck H (1975) Zur pathologischen Anatomie der Vinylchlorid-Krankheit. Virchows Arch A 368:51–59
Zimmerman HJ, Ishak KG (1982) Valproate-induced hepatic injury: analyses of 23 fatal cases. Hepatology 2:591–597
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Klinge, O. (2000). Toxische Hepatosen. In: Pathologie der Leber und Gallenwege. Spezielle pathologische Anatomie, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57036-0_9
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