Abstract
In this article, we examine the multiple connotations of the idea of ligand efficacy, from the macroscopic complexity of the signalling network in the living cell to the microscopic complexity of the single-protein macromolecule. Our analysis consists of two parts.
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Onaran, H.O., Scheer, A., Cotecchia, S., Costa, T. (2000). A Look at Receptor Efficacy. From the Signalling Network of the Cell to the Intramolecular Motion of the Receptor. In: Kenakin, T., Angus, J.A. (eds) The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems. Handbook of Experimental Pharmacology, vol 148. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57081-0_9
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