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Leishmaniasis

  • Chapter
Tropical Pathology

Part of the book series: Spezielle pathologische Anatomie ((SPEZIELLE,volume 8))

Abstract

Leishmaniases are caused by protozoa of the genus Leishmania, family Trypanosomatidae, order Kinetoplastida. With regard to the clinico-immuno-pathological aspects of leishmaniases, a wide spectrum of manifestations can be observed, with either tegumentary or visceral involvement. As in leprosy, tegumentary leishmaniasis presents with a spectrum of aspects varying from localized cutaneous and mucocutaneous leishmaniasis (CL and MCL), representing the responsive pole, to diffuse cutaneous leishmaniasis (DCL), representing the unresponsive pole. Between these polar forms a borderline or intermediate disease has been characterized (Bryceson 1969; Moriearty et al. 1978). Visceral presentations also range from subclinical to fatal disease.

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References

  • Akuffo H, Schurr E, Anderson G, Yamaneberhan T, Britton S (1987) Responsiveness in diffuse versus local cutaneous leishmaniasis is due to parasite differences. Scand J Immunol 26:717–721.

    Article  PubMed  CAS  Google Scholar 

  • Al-Gindan Y, Abdul-Aziz O, Kubba R (1984) Cutaneous leishmaniasis in Al-Hassa Saudi Arabia. Int J Dermatol 23:194–197.

    Article  PubMed  CAS  Google Scholar 

  • Al-Gindan Y, Kubba R, El Hassan AM, Orner AHS, Kutty MK, Saed MBM (1989) Dissemination in cutaneous leishmaniasis. III Lymph node involvement. Int J Dermatol 28:248–254.

    Article  PubMed  CAS  Google Scholar 

  • Andrade ZA (1991) Contribution to the study of septal fibrosis of the liver. Int J Exp Pathol 72:553–562.

    PubMed  CAS  Google Scholar 

  • Andrade ZA, Reed SG, Roters S, Sadigursky M (1984) Immunopathology of experimental cutaneous leishmaniasis. Am J Pathol 114:137–148.

    PubMed  CAS  Google Scholar 

  • Ardehali S, Sodeiphy M, Haghighi P (1980) Studies on chronic (lupoid) leishmaniasis. Ann Trop Med Parasitol 74:439–445.

    PubMed  CAS  Google Scholar 

  • Arnaud-Battandier F, Bigel P, Villain E, Lagardere B (1985) La biopsie d’intestin grêle peut elle être un moyen diagnostic des leishmanioses viscerales? Presse Med 14:792.

    PubMed  CAS  Google Scholar 

  • Ashford RW, Bettini S (1987) Ecology of epidemiology: Old World. In: Peters W, Killick-Kendrick R (eds) Biology and epidemiology. Academic, London, p 365 (The leishmaniasis in biology and medicine, vol 1).

    Google Scholar 

  • Azadeh B, Samad A, Ardehali S (1985) Histological spectrum of cutaneous leishmaniasis due to Leishmania tropica. Trans R Soc Trop Med Hyg 79:631–636.

    Article  PubMed  CAS  Google Scholar 

  • Azulay RD (1960) Histopatologia da leishmaniose tegumentar. Dermatol Ibero Lat Am 2:7–15.

    Google Scholar 

  • Badaró R, Jones TC, Lorenço R, Cerf BJ, Sampaio D, Carvalho EM, Rocha H, Teixeira R, Johnson WD Jr (1986a) A prospective study of visceral leishmaniasis in an endemic area of Brazil. J Infect Dis 154:639–649.

    Article  PubMed  Google Scholar 

  • Badaró R, Jones TC, Carvalho EM, Sampaio D, Barrai A, Teixeira R, Johnson WD Jr (1986b) New perspectives on a subclinical form of visceral leishmaniasis. J Infect Dis 154:1003–1011.

    Article  PubMed  Google Scholar 

  • Badaró R, Reed SG, Barrai A, Orge G, Jones TC (1986c) Evaluation of the micro enzyme-linked immunosorbent assay (ELISA) for antibodies in American visceral leishmaniasis: antigen selection for detection of infection specific responses. Am J Trop Med Hyg 35:72–78.

    PubMed  Google Scholar 

  • Badaró R, Falcoff E, Badaró FS, Carvalho EM, Pedral-Sampaio D, Barrai A, Carvalho JS, Barral-Netto M, Brandely M, Silva L, Bina JC, Teixeira R, Falcoff R, Rocha H, Ho JL, Johnson WD Jr (1990) Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. N Engl J Med 322:16–21.

    Article  PubMed  Google Scholar 

  • Banerjee M, Pal A, Ghosh S, Maitra TK (1990) Small intestinal involvement in visceral leishmaniasis. Am J Gastroenterol 85:1433–1434.

    PubMed  CAS  Google Scholar 

  • Barrai A, Carvalho EM, Badaró R, Barral-Netto M (1986) Suppression of lymphocyte proliferative responses by sera from patients with American visceral leishmaniasis. Am J Trop Med Hyg 35:735–742.

    Google Scholar 

  • Barrai A, Jesus AR, Almeida RP, Carvalho EM, Barral-Netto M, Costa JML, Badaró R, Rocha H, Johnson WD Jr (1987) Evaluation of T-cell subsets in the lesion infiltrates of human cutaneous and mucocutaneous leishmaniasis. Parasite Immunol 9:487–497.

    Article  Google Scholar 

  • Barrai A, Pedral-Sampaio D, Grimaldi G Jr, Momen H, McMahon-Pratt D, Jesus AR, Almeida R, Badaró R, Barral-Netto M, Carvalho EM, Johnson WD Jr (1991).

    Google Scholar 

  • Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease. Am J Trop Med Hyg 44:536–546.

    Google Scholar 

  • Barrai A, Barral-Netto M, Almeida R, Ribeiro de Jesus A, Grimaldi G Jr, Netto EM, Santos I, Bacellar O, Carvalho EM (1992) Lymphadenopathy associated with Leishmania braziliensis cutaneous infection. Am J Trop Med Hyg 47:587–592.

    Google Scholar 

  • Barrai A, Costa JML, Bittencourt AL, Barral-Netto M, Carvalho EM (1994) Polar and subpolar diffuse cutaneous leishmaniasis in Brazil: clinical and immunopathological aspects. Int J Dermatol 33.

    Google Scholar 

  • Barral-Netto M, Cardoso SA, Barrai A (1987a) Different patterns of disease in two inbred mouse strains infected with a clone of Leishmania mexicana amazonensis. Acta Trop 44:5–11.

    PubMed  CAS  Google Scholar 

  • Barral-Netto M, Freitas LAR, Andrade ZA (1987b) Histopathological changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice. Am J Pathol 127:271–278.

    PubMed  CAS  Google Scholar 

  • Barral-Netto M, Barrai A, Santos S, Carvalho EM, Badaró R, Rocha H, Reed SG, Johnson WD Jr (1991a) Soluble IL-2 receptor as an agent of serum mediated suppression in human visceral leishmaniasis. J Immunol 147:281–284.

    PubMed  CAS  Google Scholar 

  • Barral-Netto M, Badaró R, Barrai A, Almeida RP, Santos S, Badaró F, Pedral-Sampaio D, Carvalho EM, Falcoff E, Falcoff R (1991b) Tumor necrosis factor (cachectin) in human visceral leishmaniasis. J Infect Dis 163:853–857.

    Article  PubMed  CAS  Google Scholar 

  • Barral-Netto M, Barrai A, Brownell CE, Skeiky YAW, Ellingsworth LR, Twardzik DR, Reed SG (1992) Transforming growth factor beta in leishmanial infection: parasite escape mechanism. Science 257:545–548.

    Article  PubMed  CAS  Google Scholar 

  • Beaver PC, Jung BC, Cupp EW (1984) Craig and Faust’s clinical parasitology. Lea and Febiger, Philadelphia.

    Google Scholar 

  • Benhassine ML, Mokrani T, Benyahia B, Bendissari K, Keddari M, Khati B (1986) Apport de la biopsie duodénale dans le diagnostic du kala-azar. Arch Inst Pasteur Tunis 55:125–130.

    CAS  Google Scholar 

  • Berger TG, Meltzer MS, Oster CN (1985) Lymph node involvement in leishmaniasis. J Am Acad Dermatol 12:993–996.

    Article  PubMed  CAS  Google Scholar 

  • Bittencourt AL (in press) Leishmania cutânea difusa. In: Talhari S, Neves RG (eds) Dermatologia tropical. Imprensa Universitária, Manaus.

    Google Scholar 

  • Bittencourt AL, Andrade ZA (1967) Aspectos imunopatológicos na leishmaniose cutâneo-mucosa. O Hospital 71:975–984.

    PubMed  CAS  Google Scholar 

  • Bittencourt AL, Barrai A (1991) Evaluation of the histopathological classification of American cutaneous and mucocutaneous leishmaniasis. Mem Inst Oswaldo Cruz 86:51–56.

    Article  PubMed  CAS  Google Scholar 

  • Bittencourt AL, Guimarães N (1968) Imunopatologia da leishmaniose tegumentar difusa. Med Cutan Ibero Lat Am 2:395–402.

    Google Scholar 

  • Bittencourt AL, Freitas LAR (1983) Leishmaniose tegumentar difusa. Aspectos anátomopatológicos. Med Cutan Ibero Lat Am 11:265–270.

    PubMed  CAS  Google Scholar 

  • Bittencourt AL, Barrai A, Jesus AR, Almeida RP, Grimaldi G Jr (1989) In situ identification of Leishmania amazonensis associated with diffuse cutaneous leishmaniasis in Bahia, Brazil. Mem Inst Oswaldo Cruz 84:585–586.

    Article  PubMed  CAS  Google Scholar 

  • Bittencourt AL, Freitas LAR, Pompeu ML, Vieira ML, Barrai A (1990) Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis. Mem Inst Oswaldo Cruz 85:53–59.

    Article  PubMed  CAS  Google Scholar 

  • Bittencourt AL, Costa JML, Carvalho EM, Barrai A (1993) Leishmaniasis recidiva cutis in American cutaneous leishmaniasis. Int J Dermatol 32:802–805.

    Article  PubMed  CAS  Google Scholar 

  • Bonfante-Garrido R, Meléndez E, Barreto S, Mejía de Alejos MA, Momen H, Cupolillo E, McMahon-Pratt D, Grimaldi G Jr (1992) Cutaneous leishmaniasis in western Venezuela caused by infection with Leishmania venezuelensis and L. braziliensis variants. Trans R Soc Trop Med Hyg 86:141–148.

    Article  PubMed  CAS  Google Scholar 

  • Bryceson ADM (1969) Diffuse cutaneous leishmaniasis in Ethiopia. The clinical and histological features of disease. Trans R Soc Trop Med Hyg 63:708–737.

    Article  PubMed  CAS  Google Scholar 

  • Cardoso de Almeida MA, Leite da Silva SR, Falangola MF, Barral-Netto M (1989) Identification of leishmanial antigen in renal tissue in human visceral leishmaniasis. Mem Inst Oswaldo Cruz 84:95 Suppl 2.

    Google Scholar 

  • Carvalho EM, Teixeira RS, Johnson WD (1981) Cell mediated immunity in American visceral leishmaniasis. Reversible immunosuppression during acute infection. Infect Immun 22:649–654.

    Google Scholar 

  • Carvalho EM, Oliveira A Jr, Queiroz AC (1985a) Splenic immunopathology in visceral leishmaniasis (in Portuguese). Rev Soc Bras Med Trop 18:109–112.

    Article  Google Scholar 

  • Carvalho EM, Badaró R, Reed SG, Jones TC, Johnson WD Jr (1985b) Absence of gamma interferon and IL-2 production during active visceral leishmaniasis. J Clin Invest 76: 2066–2069.

    Article  PubMed  CAS  Google Scholar 

  • Carvalho EM, Johnson WD Jr, Barreto E, Marsden PD, Costa JLM, Reed SG, Rocha H (1985c) Cell mediated immunity in American cutaneous and mucosal leishmaniasis. J Immunol 135:4144–4148.

    PubMed  CAS  Google Scholar 

  • Carvalho EM, Bacellar O, Barrai A, Badaró R, Johnson WD (1989) Antigen-specific immunosuppression in visceral leishmaniasis is T cell mediated. J Clin Invest 83: 860–864.

    Article  PubMed  CAS  Google Scholar 

  • Carvalho EM, Barrai A, Pedral-Sampaio D, Barral-Netto M, Badaró R, Rocha H, Johnson WD Jr (1992) Immunologic markers of clinical evolution in children recently infected with L. donovani chagasi. J Infect Dis 165:535–540.

    Article  PubMed  CAS  Google Scholar 

  • Carvalho EM, Barrai A, Costa JML, Bittencourt AL, Marsden P (1994) Clinical and immunological aspects of disseminated cutaneous leishmaniasis. Acta Trop (Basel) 56:315–325.

    Article  CAS  Google Scholar 

  • Castanet J, Taillan B, Gamier G, Vinti H, Fuzibet JG, Dujardin P (1990) Syndrome d’hémophagocytose an cours d’une leishmaniose viscerale. Presse Med 19: 1906.

    PubMed  CAS  Google Scholar 

  • Castes M, Agnelli A, Verde O, Rondon AJ (1983) Characterization of the cellular immune response in American cutaneous leishmaniasis. Clin Immunol Immunopathol 27: 176–186.

    Article  PubMed  CAS  Google Scholar 

  • Cawson RA, McCracken AW, Marcus PB (1982) Inflammation and repair. Pathologic mechanisms and human disease. Mosby, London, p 56.

    Google Scholar 

  • CDC (1992) Viscerotropic leishmaniasis in person returning from Operation Desert Storm-1990–1991. MMWR41:131–134.

    Google Scholar 

  • Chang KP (1981) Leishmanicidal mechanisms of human polymorphonuclear phagocytes. Am J Trop Med Hyg 30:322–333.

    PubMed  CAS  Google Scholar 

  • Chulay JD, Manson-Bahr PEC (1984) Cutaneous leishmaniasis of the Old World. In: Strickland GT (ed) Hunter’s tropical medicine. Saunders, Philadelphia, p 585.

    Google Scholar 

  • Cillari E, Liew FY, Lo Campo P, Milano S, Mansueto S, Salerno A (1988) Suppression of IL-2 production by cryopreserved peripheral blood mononuclear cells from patients with active visceral leishmaniasis in Sicily. J Immunol 140:2721–2726.

    PubMed  CAS  Google Scholar 

  • Convit J, Catellanos PL, Ulrich M, Castes M, Rondon A, Pinardi ME, Rodrigues N, Bloom BR, Formica S, Valecillos L, Bretanå A (1989) Immunotherapy of localized, intermediate and diffuse forms of American cutaneous leishmaniasis. J Infect Dis 160:104–115.

    Article  PubMed  CAS  Google Scholar 

  • Corradin SB, Maul J (1991) Phagocytosis of leishmania enhances macrophage activation by IFN gamma and lipopolysaccharide. J Immunol 146:279–285.

    PubMed  CAS  Google Scholar 

  • Costa JML, Marsden PD, Llanos-Cuentas EA, Netto EM, Carvalho EM, Barrai A, Rosa AC, Cuba CC, Magalhães AV, Barretto AC (1986) Disseminated cutaneous leishmaniasis in a field clinic in Bahia, Brazil: a report of eight cases. J Trop Med Hyg 89:319–323.

    PubMed  CAS  Google Scholar 

  • Costa JML, Netto EM, Vale KC, Osaki NK, Tada MS, Marsden PD (1987) Spontaneous healing of cotaneous L. braziliensis braziliensis ulcers. Trans R Soc Trop Med Hyg 81:606.

    Article  PubMed  CAS  Google Scholar 

  • Del Prete GF, de Carli M, Mastromauro C, Biagiotti R, Macchia D, Falagiani P, Ricci M, Romagnani S (1991) Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 88:346–350.

    Article  PubMed  Google Scholar 

  • Develoux M, Blanc L, Garba S, Mamoudou HD, Warter A, Ravisse P (1990) Cutaneous leishmaniasis in Niger, Am J Trop Med Hyg 43:29–30.

    PubMed  CAS  Google Scholar 

  • Diaz HB, Martinez D, Quinones M, Estevez FN (1985) Leishmaniose anèrgica na República Dominicana. Estudo de 20 casos. An Bras Dermatol 60 Suppl:229–236.

    Google Scholar 

  • Duarte MIS (1987) Qualitative and morphometric subcellular analysis of hepatocytes and perisinusoidal area in the human visceral leishmaniasis (in Portuguese). Thesis, University of São Paulo, p 235.

    Google Scholar 

  • Duarte MIS, Corbett CEP (1984) Histopathological and ultrastructural aspects of interstitial pneumonitis of experimental visceral leishmaniasis. Trans R Soc Trop Med Hyg 78:683–688.

    Article  PubMed  CAS  Google Scholar 

  • Duarte MIS, Corbett CEP (1987) Histopathological patterns of the liver involvement in visceral leishmaniasis. Rev Inst Med Trop Med São Paulo 29:131–136.

    Article  CAS  Google Scholar 

  • Duarte MIS, Silva MRR, Goto H, Nicodemo EL, Amato Neto (1983) Interstitial nephritis in human kala-azar. Trans R Soc Trop Med Hyg 77:531–537.

    Article  PubMed  CAS  Google Scholar 

  • Duarte MIS, Matta VLR, Corbett CEP, Laurenti MD, Chebabo R, Goto H (1989) Interstitial pneumonitis in human visceral leishmaniasis. Trans R Soc Trop Med Hyg 83: 73–76.

    Article  PubMed  CAS  Google Scholar 

  • Dutra M, Martinelli R, Carvalho EM, Rodrigues LE, Brito E, Rocha H (1985) Renal involvement in visceral leishmaniasis. Am J Kidney Dis 6:22–27.

    PubMed  CAS  Google Scholar 

  • El-Hassan AM, El-Sheikh EA, Eltoum IA, Ghalib HW, Ali MS, Zijlstra E, Satti MM (1991) Post-kala-azar anterior uveitis: demonstration of Leishmania parasites in the lesion. Trans R Soc Trop Med Hyg 85:471–473.

    Article  PubMed  CAS  Google Scholar 

  • El-Safi SH, Peters W, El-Toam B, El-Kadarow A, Evans DA (1991) Studies on the leishmaniasis in the Sudan. II. Clinical and parasitological studies on cutaneous leishmaniasis. Trans R Soc Trop Med Hyg 85:457–464.

    Article  PubMed  CAS  Google Scholar 

  • Eltoum IA, Zijlstra EE, Ali MS, Ghalib HW, Satti MM, Eltoum B, El-Hassan AM (1992) Congenital kala-azar and leishmaniasis in the placenta. Am J Trop Med Hyg 46: 57–62.

    PubMed  CAS  Google Scholar 

  • Farrel JP, Muller I, Louis JA (1989) A role for Lyt-2+ T cells in resistance to cutaneous leishmaniasis in immunized mice. J Immunol 142:2052–2056.

    Google Scholar 

  • Freitas LAR, Silva LR, Oliveira P, Badaró R, Badaró F, Andrade N (1991) Small bowel involvement in visceral leishmaniasis. Mem Inst Oswaldo Cruz 86Suppl: 146.

    Google Scholar 

  • Ghalib HW, Eltoum EA, Kroon CCM, El Hassan AM (1992) Identification of Leishmania from mucosal leishmaniasis by recombinant DNA probes. Trans R Soc Trop Med Hyg 86:158–160.

    Article  PubMed  CAS  Google Scholar 

  • Girgla HS, Marsden RA, Singh GM, Ryan TJ (1977) Post-kala-azar dermal leishmaniasis. Br J Dermatol 97:307–311.

    Article  PubMed  CAS  Google Scholar 

  • Green SJ, Crawford RM, Hockmeyer JT, Meltzer MS, Nacy CA (1990) L. major amastigotes initiate the L.-arginine-dependent killing mechanism in IFN gamma stimulated macrophages by induction of tumor necrosis factor-A. J Immunol 145:4290–4297.

    PubMed  CAS  Google Scholar 

  • Griffiths WAD (1987) Old World cutaneous leishmaniasis. In: Peters W, Killick-Kendrick R (eds) Clinical aspects and control. Academic, London, p 617 (The leishmaniasis in biology and medicine, vol 2).

    Google Scholar 

  • Grimaldi G, Soares MJ, Morierty PL (1984) Tissue eosinophilia and L. mexicana mexicana eosinophil interactions in murine cutaneous leishmaniasis. Parasite Immunol 6:397–408.

    Article  PubMed  Google Scholar 

  • Grimaldi G, Tesh RB, McMahon-Pratt (1989) A review of the geographic distribution and epidemiology of leishmaniasis in the New World. Am J Trop Med Hyg 41:88–400.

    Google Scholar 

  • Guenoun FZ, Doukan S, Bouree P, Vieillefond A (1990) Un eruption cutanee diffuse et persitante chez une immuno-deprimée. Ann Pathol 10:365–366.

    PubMed  CAS  Google Scholar 

  • Gutierrez Y, Salinas GH, Palma G, Valderrama LB, Santrich CV, Saravia NG (1991) Correlation between histopathology, immune response, clinical presentation, and evolution in Leishmania braziliensis infection. Am J Trop Med Hyg 45:281–289.

    PubMed  CAS  Google Scholar 

  • Heinzel FP, Sadick MD, Mutha SS, Locksley RM (1991) Production of IFN-gamma, IL-2, IL-4 and IL-10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci USA 88:7011–7015.

    Article  PubMed  CAS  Google Scholar 

  • Hill JO, Awwad M, North RJ (1989) Elimination of CD4 suppressor T cells from susceptible BALB/c mice releases CD8 T lymphocytes to mediate protective immunity against leishmania. J Exp Med 169:1819–1827.

    Article  PubMed  CAS  Google Scholar 

  • Ho JL, Reed SG, Wick EA, Giordano M (1990) Granulocyte-macrophage and macrophage colony-stimulating factors activate intramacrophage killing of L. m. amazonensis. J Infect Dis 162:224–230.

    Article  PubMed  CAS  Google Scholar 

  • Jones TC, Johnson WD, Barreto AC, Lago E, Badaró R, Cerf B, Reed SG, Netto EM, Tada MS, França F, Wiese K, Golightly L, Fikrig E, Costa JML, Cuba CC, Marsden PD (1987) Epidemiology of American cutaneous leishmaniasis due to Leishmania braziliensis braziliensis: J Infect Dis 156:73–83.

    Article  PubMed  CAS  Google Scholar 

  • Jopling WH, Harman RRM (1986) Leprosy. In: Rook A, Wilkinson DS, Ebling FJG, Champion RH, Burton JL (eds) Text book of dermatology. Blackwell, Oxford, p 823.

    Google Scholar 

  • Kaplan G, Witmer MD, Nath I, Steinman RM, Laal S, Prasad HK, Sarno EN, Elvers V, Cohn ZA (1986) Influence of delayed immune reactions on human epidermal keratinocytes. Proc Natl Acad Sci USA 83:3469–3473.

    Article  PubMed  CAS  Google Scholar 

  • Kubba R, El Hassan AM, Al Gindan Y, Orner AHS, Kutty MK, Saed MBBS (1987a) Dissemination in cutaneous leishmaniasis. I. Subcutaneous nodules. Int J Dermatol 26:300–304.

    Article  PubMed  CAS  Google Scholar 

  • Kubba R, El-Hassan AM, Al-Gindan Y, Orner AHS, Bushra M, Kutty MK (1987b) Peripheral nerve involvement in cutaneous leishmaniasis (Old World). Int J Dermatol 26:527–531.

    Article  PubMed  CAS  Google Scholar 

  • Lainson R, Shaw JJ (1987) Evolution, classification and geographical distribution. In: Peters W, Killick-Kendric R (eds) Biology and epidemiology. Academic, London, p 1 (The leishmaniasis in biology and medicine, vol 1).

    Google Scholar 

  • Laurenti MD, Sotto MN, Corbett CEP, Matta VLR, Duarte MIS (1990) Experimental visceral leishmaniasis: sequential events of granuloma formation at subcutaneous inoculation site. Int J Exp Pathol 71:791–797.

    PubMed  CAS  Google Scholar 

  • Llãnos Cuentas EA, Cuba CC, Barreto AC, Marsden PD (1984) Clinical characteristics of human L. braziliensis braziliensis infection. Trans R Soc Trop Med Hyg 78:845–846.

    Article  Google Scholar 

  • Magalhães AV, Moraes MAP, Raick AN, Llãnos Cuentas A, Costa JML, Cuba CC, Marsden PD (1986a) Histopatologia da leishmaniose tegumentar por L. braziliensis braziliensis. 3. Reação celular nos tecidos. Rev Inst Med Trop São Paulo 28:300–311.

    Article  PubMed  Google Scholar 

  • Magalhães AV, Morais MAP, Raick A, Llãnos-Cuentas A, Costa JML, Cuba CC, Marsden PD (1986b) Histopatologia da leishmaniose tegumentar por Leishmania braziliensis braziliensis. Classificação histopatológica. Rev Inst Med Trop São Paulo 28: 421–430.

    Article  PubMed  Google Scholar 

  • Marsden PD (1986) Mucosal leishmaniasis (“espundia” Escomel, 1911). Trans R Soc Trop Med Hyg 80:859–876.

    Article  PubMed  CAS  Google Scholar 

  • Martinez-Arends A, Tapia FJ, Cáceres-Dittmar G, Mosca W, Valecillos L, Convit J (1991) Immunocytochemical characterization of immune cells in lesions of American cutaneous leishmaniasis using novel T cell markers. Acta Trop (Basel) 49:271–280.

    Article  CAS  Google Scholar 

  • Mascort-Vaca G, Bernai LP, Ruiz JBM, Morgado D, Porto-Carrero RC, Diez IG, Rivas JP (1991) Síndrome histiocito-hemofagocitaria asociada a una infeccíon por leishmania. An Esp Pediatr 35:273–275.

    PubMed  CAS  Google Scholar 

  • Mauel J (1982) Recent advances in the immunology of leishmanial infections (with particular reference to problem of vacination). Pontice Acad Sci Scripta Varia 47:91–112.

    Google Scholar 

  • Mengistu G, Laskay T, Gemetchu T, Humber D, Ersamo M, Evans D, Teferedegn H, Phelouzat MA, Frommel D (1992a) Cutaneous leishmaniasis in south-western Ethiopia: Ocholo revisited. Trans R Soc Trop Med Hyg 86:149–153.

    Article  PubMed  CAS  Google Scholar 

  • Mengistu G, Akuffo H, Fehniger TE, Negese Y, Nilsen R (1992b) Comparison of parasitological and immunological methods in the diagnosis of leishmaniasis in Ethiopia. Trans R Soc Trop Med Hyg 86:154–157.

    Article  PubMed  CAS  Google Scholar 

  • Metcalf D (1991) Control of granulocytes and macrophages: molecular, cellular and clinical aspects. Science 254:529–533.

    Article  PubMed  CAS  Google Scholar 

  • Montalban C, Martinez-Fernandez R, Callya JL, Garcia-Diaz J, Rubio R, Dronda F, Moreno S, Yebia M, Barros C, Cobo J, Martinez MC, Ruiz F, Costa JR (1989) Visceral leishmaniasis (kala-azar) as an opportunistic infection in patients infected with the human immunodeficiency virus in Spain. Rev Infect Dis 11:655–660.

    Article  PubMed  CAS  Google Scholar 

  • Moriearty P, Bittencourt AL, Pereira C, Teixeira R, Barreto E, Guimarães N (1978) Borderline cutaneous leishmaniasis. Clinical immunological and histological differences from mucocutaneous leishmaniasis. Rev Inst Med Trop São Paulo 20:15–21.

    PubMed  CAS  Google Scholar 

  • Mossmann TR, Coffman RL (1989) Heterogeneity of cytokine secretion pattern and functions of helper T cells. Adv Immunol 46:111–147.

    Article  Google Scholar 

  • Muigai R, Gatei DG, Shaunak S, Wozniak A, Bryceson ADM (1983) Jejunal function and pathology in visceral leishmaniasis. Lancet 2:476–479.

    Article  PubMed  CAS  Google Scholar 

  • Murray HW, Rubin BY, Rothermel CD (1983) Killing of intracellular L. donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that IFN-γ is the activating lymphokine. J Clin Invest 72:1506–1510.

    Article  PubMed  CAS  Google Scholar 

  • Nassiri AG, Alavi A, Sameni A (1964) Aspectos anatomo-patologiques des leishmanioses cutanées en Iran. Arch Anat Pathol 12:294–299.

    Google Scholar 

  • Nathan CF, Murray HW, Wiebe ME, Rubin BY (1983) Identification of interferon-gamma as the lymphokine that activates human macrophages oxidative metabolism and antimicrobial activity. J Exp Med 158:670–689.

    Article  PubMed  CAS  Google Scholar 

  • Navin TR, Arana FE, Mérida AM, Arana BA, Castillo AL, Silvers DN (1990) Cutaneous leishmaniasis in Guatemala: comparison of diagnostic methods. Am J Trop Med Hyg 42:36–42.

    PubMed  CAS  Google Scholar 

  • Nilsen S, Mshana RN (1987) In situ characterization of the cutaneous immune response in Ethiopian cutaneous leishmaniasis. Scand J Immunol 26:503–512.

    Article  PubMed  CAS  Google Scholar 

  • Pampiglioni S, Manson-Bahr PEC, Giungi F, Giungi G, Parenti A, Trotti GC (1974) Studies on Mediterranean leishmaniasis. 2. Asymptomatic cases of visceral leishmaniasis. Trans R Soc Trop Med Hyg 68:447–453.

    Article  Google Scholar 

  • Pearson RD, Sousa AQ (1990) Leishmania species: visceral (Kala-azar), cutaneous, and mucosal leishmaniasis. In: Mandell GL, Douglas RG, Bennet JE (eds) Principles and practice of infections diseases, 3rd edn. Churchill Livingstone, New York, p 2066.

    Google Scholar 

  • Pessoa SB, Martins AV (1981) Pessoa. Medical parasitology (in Portuguese), Guanabara Koogan, Rio de Janeiro, pp 128–129.

    Google Scholar 

  • Peters BS, Fish D, Golden R, Evans DA, Bryceson AD, Pinching AJ (1990) Visceral leishmaniasis in HIV infection and AIDS: clinical features and response to therapy. Q J Med 77:1101–1111.

    Article  PubMed  CAS  Google Scholar 

  • Pirmez C, Oliveira-Neto MP, Grimaldi G Jr, Savino W (1990a) Immunopathology of American cutaneous leishmaniasis. Modulation of MHC class II gene products by keratinocytes before and after glucantime therapy. Mem Inst Oswaldo Cruz 85: 203–209.

    Article  PubMed  CAS  Google Scholar 

  • Pirmez C, Cooper C, Paes-Oliveira M, Schubach A, Torigian VK, Modlin RL (1990b) Immunologic responsiveness in American cutaneous leishmaniasis lesions. J Immunol 145:3100–3104.

    PubMed  CAS  Google Scholar 

  • Pompeu ML, Freitas LA, Santos MLV, Khouri M, Barral-Netto M (1991) Granulocytes in the inflammatory process of BALB/c mice infected by L. amazonensis. A qualitative approach. Acta Trop (Basel) 48:185–193.

    Article  CAS  Google Scholar 

  • Pompeu ML, Freitas AL, Reis GA, Barral-Netto M (1992) T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice. Parasitol Res 78:16–22.

    Article  PubMed  CAS  Google Scholar 

  • Pontes de Carvalho LC, Badaró R, Carvalho EM, Larmes-Vieira J, Vinhaes L, Orge G, Marsochi MCA, Galvão-Castro B (1986) Nature and incidence of erythrocyte-bound IgG and some aspects of the physiopathogenesis of anaemia in American visceral leishmaniasis. Clin Exp Immunol 64:495–502.

    PubMed  CAS  Google Scholar 

  • Reed SG, Badarã R, Masur H, Carvalho EM, Lorenco R, Lisboa A, Teixeira R, Johnson WD, Jones TC (1986) Selection of a skin test antigen for American cutaneous leishmaniasis. Am J Trop Med Hyg 35:79–85.

    PubMed  CAS  Google Scholar 

  • Rees PH, Kager PA (1987) Visceral leishmaniasis and post-Kala-azar dermal leishmaniasis. In: Peters W, Killick-Kendrick R (eds) The leishmaniases: clinical aspects and control. Academic, London, p 583 (The leishmaniasis in biology and medicine vol 2).

    Google Scholar 

  • Ridley DS (1980) A histological classification of cutaneous leishmaniasis and its geographical expression. Trans R Soc Trop Med Hyg 74:515–521.

    Article  PubMed  CAS  Google Scholar 

  • Ridley DS (1987) Pathology. In: Peters W, Killick-Kendrick R (eds) Clinical aspects and control. Academic, London, p 665 (The leishmaniasis in biology and medicine vol 2).

    Google Scholar 

  • Ridley DS, Ridley MJ (1983) The evolution of the lesion in cutaneous leishmaniasis. JPathol 141:83–96.

    Article  CAS  Google Scholar 

  • Robbins SL, Coran RS (1991) Pathologic basis of disease. Saunders, Philadelphia, p 71.

    Google Scholar 

  • Sadeghi-Hasanabadi A, Nader K, Abdollahi B, Tahei Z, Varedi M, Imani M (1987) An outbreak of leishmaniasis with unusual presentation in Shiraz, Iran. Trans R Soc Trop Med Hyg 81:359.

    Article  PubMed  CAS  Google Scholar 

  • Satti MB, El Hassan AM, Al-Ginda Y, Osman MA, Al-Sohaibani MO (1989) Peripheral neural involvement in cutaneous leishmaniasis. A pathological study of human and experimental animal lesions. Int J Dermatol 28:243–247.

    Article  PubMed  CAS  Google Scholar 

  • Scott P, Natovitz P, Cofrman RL, Pearce E, Sher A (1988) Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med 168:1675–1684.

    Article  PubMed  CAS  Google Scholar 

  • Scuderi P, Lam KS, Ryan KJ, Petersen EA, Sterling KE, Finley PR, Ray CG, Slymen DJ, Salmon SE (1986) Raised serum levels of tumor necrosis factor in parasitic infections. Lancet 2:1364–1365.

    Article  PubMed  CAS  Google Scholar 

  • Sendino A, Barbado FJ, Mostaza JM, Fernandez-Martin J, Larrauri J, Vasquez-Rodrigues JJ (1990) Visceral leishmaniasis with malabsorption syndrome in a patient with acquired immunodeficiency syndrome. Am J Med 89:673–675.

    Article  PubMed  CAS  Google Scholar 

  • Silveira FT, Lainson R, Shaw JJ, De Souza AA, Ishikawa EA, Braga RR (1991) Cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis in Amazonian Brazil, and the significance of a negative Montenegro skin test in human infections. Trans R Soc Trop Med Hyg 85:735–738.

    Article  PubMed  CAS  Google Scholar 

  • Smith LE, Rodrigues M, Russell DG (1991) The interaction between CD8+ cytotoxicity T cells and leishmania infected macrophages. J Exp Med 174:499–505.

    Article  PubMed  CAS  Google Scholar 

  • Solbach W, Lohoff M, Streck H, Rohwer P, Rollinghoff M (1987) Kinetics of cell mediated immunity developing during the course of Leishmania major infection in “healer” and non “healer” mice: progressive impairment of response to and generation of interleukin-2. Immunology 62:485–492.

    PubMed  CAS  Google Scholar 

  • Sotto MN, Yamashiro-Kanashiro EH, Matta VL, Brito T (1989) Cutaneous leishmaniasis of the New World: diagnostic immunopathology and antigen pathways in skin and mucosa. Acta Trop (Basel) 46:121–130.

    Article  CAS  Google Scholar 

  • Streilein JW (1989) Skin associated lymphoid tissue. In: Noms DA (ed) Immune mechanisms in cutaneous disease. Dekker, New York, p 73.

    Google Scholar 

  • Titus RG, Ribeiro JMC (1988) Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance leishmania infectivity. Science 239:1306.

    Article  PubMed  CAS  Google Scholar 

  • Velasco OV, Savarino SJ, Walton BC, Gam AA, Neva FA (1989) Diffuse cutaneous leishmaniasis in Mexico. Am J Trop Med Hyg 41:280–288.

    PubMed  CAS  Google Scholar 

  • Veress B, El Hassan AM (1986) Vascular changes in human leishmaniasis: a light microscope and immunohistological study. Ann Trop Med Parasitol 80:183–188.

    PubMed  CAS  Google Scholar 

  • Veress B, Omer A, Satir AA, El Hassan AM (1977) Morphology of spleen and lymph nodes in fatal visceral leishmaniasis. Immunology 33:605–610.

    PubMed  CAS  Google Scholar 

  • Walton BC (1987) American cutaneous and mucocutaneous leishmaniasis. In: Peters W, Killick-Kendrick R (eds) Clinical aspects and control. Academic, London, p 637 (The leishmaniasis in biology and medicine vol 2).

    Google Scholar 

  • Weiser WY, Van Neil A, Clark SC, David JR, Remold HG (1987) Recombinant human granulocyte/macrophage colony-stimulating factor activates intracellular killing of L. donovani by human monocyte-derived macrophages. J Exp Med 166:1436.

    Article  PubMed  CAS  Google Scholar 

  • Wilson ME, Innes DJ, Sousa AQ, Pearson RD (1987) Early histopathology of experimental infection with Leishmania donovani in hamsters. J Parasit 73:55–63.

    Article  PubMed  CAS  Google Scholar 

  • Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, Modlin RL (1991) Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254:277–279.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. A. L. Bittencourt
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  2. M. Barral-Netto
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© 1995 Springer-Verlag Berlin Heidelberg

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Bittencourt, A.L., Barral-Netto, M. (1995). Leishmaniasis. In: Tropical Pathology. Spezielle pathologische Anatomie, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57863-2_14

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  • DOI: https://doi.org/10.1007/978-3-642-57863-2_14

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