Abstract
Nisoldipine is a calcium channel blocking agent with dihydropyridinic structure, chemically derived from the first calcium antagonist dihydropyridine nifedipine. Its pharmacological properties differ from those of the parent drug in that nisoldipine appears to be a more potent and selective vasodilator of vascular smooth muscle, thus showing at equihypothensive doses less depressant effects upon myocardial contractility [1]. The possibility to achieve effective vasodilation in the coronary circulation [2] without the risk of a negative inotropic action would be extremely useful in the treatment of patients with coronary artery disease (CAD) and reduced myocardial contractile function. The present study was undertaken to further elucidate the acute hemodynamic effects of nisoldipine in patients with CAD and impaired left ventricular function.
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© 1991 Springer-Verlag Berlin Heidelberg
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Ghio, S. et al. (1991). Acute Hemodynamic Effects of Nisoldipine in Patients with Coronary Artery Disease and Reduced Left Ventricular Function. In: Lewis, B.S., Kimchi, A. (eds) Heart Failure Mechanisms and Management. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58231-8_34
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DOI: https://doi.org/10.1007/978-3-642-58231-8_34
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-63509-0
Online ISBN: 978-3-642-58231-8
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