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Toll-Like Receptors and Their Ligands

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Toll-Like Receptor Family Members and Their Ligands

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 270))

Abstract

The Toll-like receptors (TLRs) are key molecules involved in the recognition of pathogens by the innate immune system. This family of germ line-encoded receptors has evolved to recognize conserved features of microbes. Currently, 10 TLR family members have been identified in mammals. The number of ligands for these receptors continues to grow, and it seems clear that multiple ligands exist for each receptor. Whether engagement of different TLRs leads to differences in gene expression and thereby differences in the immune response remains to be seen. However, recent work has demonstrated that activation of TLRs is required for initiation of only certain adaptive immune responses.

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Authors and Affiliations

  1. Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar St., BML 458, New Haven, CT, 06520, USA

    G. M. Barton & R. Medzhitov

Authors
  1. G. M. Barton
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  2. R. Medzhitov
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Editor information

Editors and Affiliations

  1. Department of Immunology, The Scripps Research Institute, 10550 N. Torreye Pines Road, 92037, La Jolla, California, USA

    Bruce Beutler M.D.

  2. Institut für Medizinische Mikrobiologie, Immunologie and Hygiene Technische Universität München, Trogerstr. 9, 81675, München, Germany

    Hermann Wagner

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© 2002 Springer-Verlag Berlin Heidelberg

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Barton, G.M., Medzhitov, R. (2002). Toll-Like Receptors and Their Ligands. In: Beutler, B., Wagner, H. (eds) Toll-Like Receptor Family Members and Their Ligands. Current Topics in Microbiology and Immunology, vol 270. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59430-4_5

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  • DOI: https://doi.org/10.1007/978-3-642-59430-4_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63975-3

  • Online ISBN: 978-3-642-59430-4

  • eBook Packages: Springer Book Archive

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