Abstract
The pharmacokinetic and pharmacodynamic aspects of antimicrobials can be integrated using the AUIC, which is the AUC24/MIC. Based on a study in patients with nosocomial pneumonia, a ciprofloxacin AUIC < 125 did not eradicate the pathogen in 2/3 of patients. An AUIC > 250 produced the most rapid and complete eradication. Experience has shown that the pathogens with MIC values below the AUIC value of 100 are responsible for the emergence of resistance. Therefore, resistance can be avoided by adequately exceeding the AUIC of 100 with those pathogens. Most rapid killing of organisms can be achieved with AUIC target values of 250.
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© 2000 Springer-Verlag Berlin Heidelberg
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Schentag, J.J. (2000). Mini-Reviews — Pharmacokinetics/Pharmacodynamics (PK/PD). In: Mandell, L. (eds) First International Moxifloxacin Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59681-0_17
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DOI: https://doi.org/10.1007/978-3-642-59681-0_17
Publisher Name: Springer, Berlin, Heidelberg
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