Abstract
Somatostatin is one of the most widespread neuropeptides in the brain. Receptors are found not only on neurons, but also on astroglia and meningeal cells in vitro and in situ and on microglia cells at least in vitro. Moreover, somatostatin receptors are overexpressed in malignant derivatives of these cells, human gliomas and meningiomas. In human gliomas and glial cell lines the receptors are located mainly on the processes of the cells and only rarely on the somata. Interestingly, the pattern of somatostatin receptor subtypes (sst) differs between normal astrocytes and gliomas or glioma cell lines. Whereas astrocytes express multiple subtypes (sst1, sst2, sst4) the subtype sst2 is predominant in gliomas (often with low levels of other subtypes). Somatostatin inhibits the basal or agonist-stimulated proliferation of microglia cells, but not of astrocytes or gliomas. The reason for this lack of inhibitory action in astrocytes or gliomas might be (in part) a desensitization of the receptor, e.g. by phosphorylation. An increased phosphorylation of the receptor sst2, after stimulation with its agonist, was observed in U343 glioma cells metabolically labeled with radioactive phosphate. These results show that not only neurons but also non-neuronal cells have to be considered as target cells for neuropeptides in the brain.
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References
Brazeau P, Vale W, Burgus R, Ling N, Rivier J, Guillemin R (1972) Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 129: 77–79
Bruno JF, Xu Y, Song J, Berelowitz M (1993) Tissue distribution of somatostatin receptor subtype messenger ribonucleic acid in the rat. Endocrinology 133: 2561–2567
Feindt J, Becker I, Blomer U, Hugo H-H, Mehdorn HM, Krisch B, Mentlein R (1995) Expression of somatostatin receptor subtypes in cultured astrocytes and gliomas. J Neurochem 65: 1997–2005
Feindt J, Hugo H-H, Mentlein R, Krisch B (1996) Somatostatin receptor subtypes in human astrocytes and gliomas: influence of cultivation process. In: Krisch B, Mentlein R (eds) The peptidergic neuron. Birkhauser Verlag, Basel, pp 141–150
Feindt J, Krisch B, Lucius R, Mentlein R (1997) Meningeal cells are targets and inactivation sites for the neuropeptide somatostatin. Mol Brain Res 44: 293–300
Feindt J, Krisch B, Mentlein R (1997b) Time-dependent influence of the somatostatin analog octreotide on the proliferation of rat astrocytes and glioma cells. Brain Res 746: 309–313
Florio T, Schettini G (1996) Multiple intracellular effectors modulate physiological functions of the cloned somatostatin receptors. J Mol Endocrinol 17: 89–100
Hildebrandt G, Scheidhauer K, Luyken C, Schicha H, Klug N, Dahms P, Krisch B (1994) High sensitivity of the in vivo detection of somatostatin receptors by inindium-[DTPA-ocreotide]-scintigraphy in meningioma patients. Acta Neurochir (Wien) 126: 63–71
Krisch, B. (1980) Differing immunoreactivities of somatostatin in the cortex and hypothalamus of the rat. Cell Tissue Res 212: 457–464
Krisch B (1994) Somatostatin binding sites in functional systems of the brain. Progr Histochem Cytochem 28: 1–40
Krisch B, Mentlein R (1994) Neuropeptide receptors and astrocytes. Int Rev Cytol 148: 119–169
Krisch B, Buchholz C, Mentlein R (1991) Somatostatin binding sites on rat diencephalic astrocytes. Light-microscopic study in vitro and in vivo. Cell Tissue Res 263: 253–263
Krisch B, Buchholz C, Mentlein R, Turzynski A (1993) Visualization of neuropeptide-binding sites on individual telencephalic neurons of the rat. Cell Tissue Res 272: 523–531
Lecca L, Criado JR, Prospero-Garcia O, Gautvik KM, Schweitzer P, Danielson PE, Dunlop CL, Siggins GR, Henriksen SJ, Sutcliff JG (1996) A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature 381: 242–245
Luyken C, Hildebrandt G, Scheidhauer K, Krisch B, Schicha H, Klug N (1994) luIndium (DTPA-octreotide) scintigraphy in patients with cerebral gliomas. Acta Neurochir (Wien) 127: 60–64
Mentlein R, Buchholz C, Krisch B (1990) Somatostatin-binding sites on rat telencephalic astrocytes. Light- and electron-microscopic studies in vitro and in vivo. Cell Tissue Res 262: 431–443
Mentlein R, Feindt J, Schmidt A (1997) Somatostatin receptor subtypes and their effects in microglia cells. J Neurochem (submitted)
Patel YC, Srikant CB (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1–5). Endocrinology 135: 2814–2817
Porter JT, McCarthy KD (1997) Astrocytic neurotransmitter receptors in situ and in vivo. Progr Neurobiol 51: 439–455
Reubi JC, Laissue J, Krenning E, Lamberts SWJ (1992) Somatostatin receptors in human cancer: incidence, characteristics, functional correlates and clinical implications. J Steroid Biochem Mol Biol 43: 27–35
Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter, Schüle R (1993) Cloning and characterization of a fourth human somatostatin receptor. Proc Natl Acad Sci USA 90: 4196–4200
Schindler M, Humphrey PPA, Emson PC (1996) Somatostatin receptors in the central nervous system. Progr Neurobiol 50: 9–47
Schneider M (1997) Somatostatinrezeptoren an humanen Gliatumoren in vitro. Dissertation
Medizinische Fakultät der Christian-Albrechts-Universität zu Kiel Weckbecker G, Raulf F, Stolz B, Bruns C (1993) Somatostatin analogs for the diagnosis and treatment of cancer. Pharmacol Therapeut 60: 245–264
Wilkin GP, Marriott DR, Pearce B (1995) Peptide receptors on astrocytes. In: Kettenmann H, Ransom RB (eds) Neuroglia. Oxford University Press, Oxford, pp 367–376
Yamada Y, Post SR, Wang K, Tager HS, Bell GI, Seino S (1992a) Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci USA 89: 251–255
Yamada Y, Reisine T, Law SF, Ihara Y, Kubota A, Kagimoto S, Seino M, Seino Y, Bell GI, Seino S (1992b) Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. Mol Pharmacol 6: 2136–2142
Yamada Y, Kagimoto S, Kubota A, Yasuda K, Masuda K, Someya Y, Ihara Y, Li Q, Imura H, Seino S, Seino Y (1993) Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and fifth (hSSTR5) human somatostatin receptor subtype. Biochem Biophys Res Commun 195: 844–852
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Feindt, J., Krisch, B., Mentlein, R. (1997). Receptors and Effects of the Inhibitory Neuropeptide Somatostatin in Glial Derivatives. In: Korf, HW., Usadel, KH. (eds) Neuroendocrinology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60915-2_20
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DOI: https://doi.org/10.1007/978-3-642-60915-2_20
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