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Cell-Cell Interactions in Osteoblastic Metastasis Caused by Advanced Prostate Cancer

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Tumor Biology

Part of the book series: NATO ASI Series ((ASIH,volume 99))

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Abstract

Among solid tumors metastasizing to the skeleton prostate adenocarcinoma and breast cancer are those producing an osteoblastic reaction. The incidence of pure osteoblastic metastases is 95% for metastatic prostate cancer and 8% for metastatic breast cancer (Sharpe and McDonald, 1942). Pure lytic lesions in metastatic prostate cancer is not a common finding. Consequently, metastatic prostate adenocarcinoma is a unique cancer with regard to its ability to promote new bone formation. Among other important events in the process of bone metastasis, cell-cell interaction between metastatic cancer cells and host tissue regulate not only the establishment of the metastatic tumor but also the development of the local osteoblastic reaction (Galasko, 1982). Skeletal metastases in prostate cancer patients are frequently the only sites of disease progression after long-lasting remission achieved by androgen depletion therapies and practically determine the outcome of prostate cancer patients (Koutsilieris and Tolis, 1985).

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Author information

Authors and Affiliations

  1. Molecular Endocrinology Laboratory, CHUL Research Center, Centre Hospitalier de L’ Universite Laval (CHUL), Ste-Foy, Quebec, G1V 4G2, Canada

    Michael Koutsilieris

  2. Clinic of Hormones, CHUL Research Center, Centre Hospitalier de L’ Universite Laval (CHUL), Ste-Foy, Quebec, G1V 4G2, Canada

    Michael Koutsilieris

  3. Cancer Therapies, CHUL Research Center, Centre Hospitalier de L’ Universite Laval (CHUL), Ste-Foy, Quebec, G1V 4G2, Canada

    Michael Koutsilieris

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  1. Michael Koutsilieris
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Editor information

Editors and Affiliations

  1. Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54006, Thessaloniki, Greece

    Asterios S. Tsiftsoglou

  2. Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA

    Alan C. Sartorelli

  3. Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E17-536, 02139, Cambridge, MA, USA

    David E. Housman

  4. Department of Experimental Hematology, Christie Hospital, NHS Trust Paterson Institute for Cancer Research, Wilmslow Road, M20 9BX, Manchester, UK

    T. Michael Dexter

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© 1996 Springer-Verlag Berlin Heidelberg

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Koutsilieris, M. (1996). Cell-Cell Interactions in Osteoblastic Metastasis Caused by Advanced Prostate Cancer. In: Tsiftsoglou, A.S., Sartorelli, A.C., Housman, D.E., Dexter, T.M. (eds) Tumor Biology. NATO ASI Series, vol 99. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61180-3_14

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  • DOI: https://doi.org/10.1007/978-3-642-61180-3_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64735-2

  • Online ISBN: 978-3-642-61180-3

  • eBook Packages: Springer Book Archive

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