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Pharmacokinetics of Vasodilating Agents

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Acute and Chronic Heart Failure

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Abstract

Studies on the metabolism of nitroglycerin in various animal species have shown distinct differences making it problematic to extrapolate from experimental animal data to humans. Needleman et al. (1972) found complete inactivation of nitrates following oral administration in rats as a result of the first-pass effect in the liver.

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Authors and Affiliations

  1. Zentrum der Inneren Medizin, Abteilung für Kardiologie, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, D-6000, Frankfurt 70, Germany

    Professor Dr. med. Wulf-Dirk Bussmann

Authors
  1. Professor Dr. med. Wulf-Dirk Bussmann
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© 1986 Springer-Verlag Berlin Heidelberg

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Bussmann, WD. (1986). Pharmacokinetics of Vasodilating Agents. In: Acute and Chronic Heart Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61627-3_12

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  • DOI: https://doi.org/10.1007/978-3-642-61627-3_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64890-8

  • Online ISBN: 978-3-642-61627-3

  • eBook Packages: Springer Book Archive

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