Abstract
Terminal deoxynucleotidyl transferase (TdT), a unique DNA polymerase that does not require a template, is found in thymocytes and marrow T-lymphocytes normally [1,2]. Shortly after these discoveries, McCaffrey et al. [3] described the presence of this enzyme in the leukemic cells of patients with acute lymphoblastic leukemia (ALL) and Sarin et al. [4] discovered that some patients with chronic myelocytic leukemia in blast crisis have TdT activity in leukemic cells. Currently, the data from a number of laboratories indicates that most patients with ALL have TdT-positive blasts and most patients with acute nonlymphocytic leukemia (ANLL) have TdT-negative blasts [5,6].
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References
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Wiernik, P.H., Edwards, L.S., Sarin, P.S. (1979). Marrow Terminal Deoxynucleotidyl Transferase Activity in Adult Acute Leukemia. In: Neth, R., Gallo, R.C., Hofschneider, PH., Mannweiler, K. (eds) Modern Trends in Human Leukemia III. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67057-2_15
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DOI: https://doi.org/10.1007/978-3-642-67057-2_15
Publisher Name: Springer, Berlin, Heidelberg
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