Skip to main content
SpringerLink
Log in

Befunde zur Pathogenese sekundärer Hyperlipoproteinämien

  • Chapter
Fortschritte in der Inneren Medizin

Zusammenfassung

Die klinische Bedeutung sekundärer Hyperlipoproteinämien beruht auf der diagnostischen und prognostischen Wertigkeit von Abweichungen der Plasmalipidkonzentrationen bei einer Reihe heterogener Erkrankungen. Dazu gehören die Hypercholesterinämie bei Hypothyreose, Hypertriglyzeridämie bei abdominellen Krisen und Pankreatitis und die Lipidstoffwechselstörungen bei Lebererkrankungen. Daneben wird der Verlauf anderer Erkrankungen, wie Diabetes mellitus und chronischer Niereninsuffizienz, die mit lange persistierenden Fettstoffwechselstörungen einhergehen können, häufig durch kardiovaskuläre Komplikationen bestimmt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Lewis B: Secondary hyperlipidaemias and rare forms of Hyperlipoproteinaemia. In: The Hyperlipidaemias (Lewis B, ed). Blackwell, Oxford-London 1976.

    Google Scholar 

  2. Robinson DS: The clearing factor lipase and its action in the transport of fatty acids between the blood and the tissues. Adv Lipid Res 1: 133–182 (1963).

    PubMed  CAS  Google Scholar 

  3. Fielding CJ, Havel RJ: Lipoprotein lipase. Arch Pathol Lab Med 101: 229–255 (1977).

    Google Scholar 

  4. Flint A, Jr: Experimental researches into a new excretory function of the liver, consisting in the removal of Cholesterine from the blood, and its discharge from the body in the form of stercorine. Am J Med Sci 44:305–365 (1862).

    Article  Google Scholar 

  5. Rothschild MA, Felsen J: The cholesterol content of the blood in various hepatic conditions. Arch Intern Med 24:520 (1919).

    Article  CAS  Google Scholar 

  6. Gofman JW, Delalla O, Glazier F: The plasma lipoprotein transport system in health, metabolic disorders, atherosclerosis and coronary heart disease. Plasma 2: 413–484 (1954).

    Google Scholar 

  7. Eder HA, Russ EM, Rees Pritchet RA: Proteinlipid relationships in human plasma in biliary cirrhosis, obstructive jaundice and acute hepatits. J Clin Invest 35:133–144 (1956).

    Article  Google Scholar 

  8. Seidel D, Alaupovic P, Furman RH: A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects. J Clin Invest 48: 1211–1223 (1969).

    Article  PubMed  CAS  Google Scholar 

  9. Seidel D, Alaupovic P, Furman RH, McConathy WJ: A lipoprotein characterizing obstructive jaundice. II. Isolation and partial characterization of the protein moiety of low density lipoproteins. J Clin Invest 49:2396–2407 (1970).

    Article  PubMed  CAS  Google Scholar 

  10. Wengeler H, Greten H, Seidel D: Serum Cholesterin esterification in lever disease. Combined determinations of lecithin: cholesterol acyltransferase and lipoprotein-X. Eur J Clin Invest 2: 372–378 (1970).

    Article  Google Scholar 

  11. Sabesin SM, Hawkins HL, Kuiken L, Ragland JB: Abnormal plasma lipoproteins and lecithincholesterol acyltransferase deficiency in alcoholic liver disease. Gastroenterology 72: 510–518 (1977).

    PubMed  CAS  Google Scholar 

  12. Phillips GB: The lipid composition of serum in patients with liver disease. J Clin Invest 39: 1639–1649 (1960).

    Article  PubMed  CAS  Google Scholar 

  13. Müller P, Fellin R, Lambrecht J, Agostini B, Wieland H, Rost W, Seidel D: Hypertriglyceridemia secondary to liver disease. Eur J Clin Invest 4: 419–428 (1974).

    PubMed  Google Scholar 

  14. Seidel D, Greten H, Geisen HP, Wengeler H, Wieland H: Further aspects on the characterization of high and very low density lipoproteins in patients with liver disease. Eur J Clin Invest 2: 359–364 (1972).

    Article  PubMed  CAS  Google Scholar 

  15. Mordasini RC, Berthold S, Schlumpf E, Riva G: Veränderungen der Serumlipide und-lipoproteine bei akuter Hepatitis. Schweiz Med Wschr 106: 1173–1182 (1976).

    PubMed  CAS  Google Scholar 

  16. Middelhoff G, Mordasini R, Stiehl A, Greten H: A bile-acid-rich high density lipoprotein (HDL) in acute hepatitis. Scand J Gastroent 14: 267–272 (1979).

    Article  PubMed  CAS  Google Scholar 

  17. Marble A: The natural history of diabetes. In: International Symp. on Lipid Metabolism, Obesity and Diabetes mellitus: Impact upon Atherosclerosis, pp 153–158. Thieme, Stuttgart (1974).

    Google Scholar 

  18. Albrink MJ, Lavietes PH, Man EB: Vascular diseases and serum lipids in diabetes mellitus. Ann Int Med 58:305 (1963).

    PubMed  CAS  Google Scholar 

  19. Nikkilä EA, Kekki M: Plasma triglyceride transport kinetics in diabetes mellitus. Metabolism 22: 1–22 (1973).

    Article  PubMed  Google Scholar 

  20. Bierman EL, Porte D Jr, Bagdade JD: Hypertriglyceridemia and glucose intolerance in man. In: Jeanrenaud B, Hepp D (eds) Adipose tissue, pp 209–212. Academic Press, New York (1970).

    Google Scholar 

  21. Nikkilä EA, Huttunen JK, Ehnholm C: Postheparin plasma lipoprotein lipase and hepatic lipase in diabetes mellitus. Diabetes 26:11 (1977).

    Article  PubMed  Google Scholar 

  22. Brunzell JD, Porte D Jr, Bierman EL: Reversible abnormalities in postheparin lipolytic activity during the late phase of release in diabetes mellitus (postheparin lipolytic activity in diabetes). Metabolism 24:1123–1137 (1975).

    Article  PubMed  CAS  Google Scholar 

  23. Pykalistö OJ, Smith PJ, Brunzell JD: Determinants of human adipose tissue lipoprotein lipase — effect of diabetes and obesity on basal-and dietinduced activity. J Clin Invest 56:1108 (1975).

    Article  PubMed  Google Scholar 

  24. Brunzell JD, Porte D Jr, Bierman EL: Abnormal lipoprotein lipase — mediated plasma triglyceride removal in untreated diabetes mellitus associated with hypertriglyceridemia. Metabolism 28 (9): 901 (1979).

    Article  PubMed  CAS  Google Scholar 

  25. Heuck CC, Ritz E: Hyperlipoproteinemia in renal insufficiency. Nephron 25: 1–7 (1980).

    Article  PubMed  CAS  Google Scholar 

  26. Mordasini R, Frey F, Flury W, Klose G, Greten H: Selective deficiency of jepatic triglyceride lipase in uremic patients. N Engl J Med 297:1362 (1977).

    Article  PubMed  CAS  Google Scholar 

  27. Applebaum-Bowden D, Goldberg AP, Hazzard W et al: Postheparin plasma triglyceride lipases in chronic hemodialysis: evidence for a role for hepatic lipase in lipoprotein metabolism. Metabolism 28:917–924 (1979).

    Article  PubMed  CAS  Google Scholar 

  28. Bagdade JD: Atherosclerosis in patients undergoing maintance hemodialysis. Kidney Int 7 (Suppl 3): 370–372 (1975).

    Google Scholar 

  29. Kekki M, Nikkilä EA: Plasma triglyceride metabolism in adult nephrotic syndrome. Eur J Clin Invest 1:345 (1971).

    Article  PubMed  CAS  Google Scholar 

  30. Feigl J: Neue Untersuchungen zur Chemie des Blutes bei akuter Alkoholintoxikation und bei chronischem Alkoholismus mit besonderer Berücksichtigung der Fette und Lipoide. Biochem Z 92:282–317 (1918).

    CAS  Google Scholar 

  31. Castelli WP, Gordon T, Hjortland MC, Kagan A, Harnes CG, Hulley SB, Zukel WJ: Alcohol and blood lipids: the cooperative lipoprotein phenotyping study. LancetII: 153–158 (1977).

    Article  Google Scholar 

  32. Baraona E, Lieber C: Effects of ethanol on lipid metabolism. J Lipid Res 20:289–315 (1979).

    PubMed  CAS  Google Scholar 

  33. Nikkilä EA, Taskinen MR, Huttunen JK: Effect of acute ethanol load on postheparin plasma lipoprotein lipase and hepatic lipase activities and intravenous fat tolerance. Horm Metab Res 10: 220–223 (1978).

    Article  PubMed  Google Scholar 

  34. Belfrage P, Berg B, Högerstrand J, Nilsson-Ehle P, Tornquist H, Wiebe T: Alterations of lipid metabolism in healthy volunteers during long-term ethanol intake-Eur J Clin Invest 7:127–131 (1977).

    Article  CAS  Google Scholar 

  35. Speck L: Fall von Lipämie. Arch des Vereins für wissenschaftliche Heilkunde 1:232 (1865).

    Google Scholar 

  36. Klatskin G, Gordon M: Relationship between relapsing pancreatitis and essential hyperlipemia. Am J Med 12:3–14 (1952).

    Article  PubMed  CAS  Google Scholar 

  37. Wang C, Adlersberg D, Feldman EB: Serum lipids in acute pancreatitis. Gastroenterology 36: 832–840 (1959).

    PubMed  CAS  Google Scholar 

  38. Cameron JL, Capuzzi DM, Zuidema GD, Margolis S: Acute pancreatitis with hyperlipemia: the incidence of lipid abnormalities in acute pancreatitis. Ann Surg 177:483–489 (1973).

    Article  PubMed  CAS  Google Scholar 

  39. Kessler JI, Kniffen JC, Janowitz HD: Lipoprotein lipase inhibition in the hyperlipemia of acute alcoholic pancreatitis. N Engl J Med 269: 943–948 (1963).

    Article  PubMed  CAS  Google Scholar 

  40. Bagdade JD: Diabetic lipaemia complicating acute pancreatitis. LancetII: 1042–1043 (1969).

    Google Scholar 

  41. Klose G, Greten H: Zur Pathogenese der Hyperlipämien bei Patienten mit Pankreatitis. In: Tittor W, Schwalbachn G (Hrsg) Leberdurchblutung und Kreislauf, Thieme, Stuttgart (1981).

    Google Scholar 

  42. Murase T, Uchimura H: A selective decline of postheparin plasma hepatic triglyceride lipase in hypothyroid rats. Metabolisum 29. (8): 797 (1980).

    Article  CAS  Google Scholar 

  43. Hülsmann WC, Oerlemans MC, Geelhoed-Mieras: Effect of hypothyroidism, diabetes and polyunsaturated fatty acids of heparin-releasable rat liver lipase. Biochem Biophys Res Comm 19 (3): 784–788 (1977).

    Article  Google Scholar 

  44. Pykälistö O, Goldberg AP, Brunzell JD: Reversal of decreased human-adipose tissue lipoprotein lipase and hypertriglyceridemia after treatment of hypothyroidism. J Clin Endocrin Metab 43: 591–600 (1976).

    Article  Google Scholar 

  45. Kirkeby K: Post-heparin plasma lipoproteinlipase acitivity in thyroid disease. Acta Endocrin (Kbh) 59:55–563 (1968).

    Google Scholar 

  46. Lithell H, Boberg J, Hellsing K: Serum lipoprotein and apoprotein concentration and tissue lipoprotein-lipase activity in overt and subclinical hypothyroidism: the effect of substitution therapy. Eur J Clin Invest 11(3): 10(1981).

    Google Scholar 

  47. Ehnholm C, Huttunen JK, Kinnunen PJ, Miettinen TA, Nikkilä EA: Effect of oxandrolone treatment on the activity of lipoprotein lipase, hepatic lipase and phospholipase A1 of human postheparinplasma. N Engl J Med 292:1314 (1975).

    Article  PubMed  CAS  Google Scholar 

  48. Kinnunen KP, Unnerus HE, Ranta T, Ehnholm, C. Nikkila, E. A., Seppällä, M.: Activities of postheparin plasma lipoprotein lipase and hepatic lipase during pregnancy and lactation. Eur J Clin Invest 10:469–474.

    Google Scholar 

  49. Hamosh M, Hamosh P: The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue. J Clin Invest 55:1132–1135 (1975).

    Article  PubMed  CAS  Google Scholar 

  50. Klose G, Windelband J, Weizel A, Greten H: Secondary hypertriglyceridemia in patients with parenchymal liver disease. Europ J Clin Invest 7:557–562 (1977).

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. G. Klose
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Windler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Greten
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik (Ludolf-Krehl-Klinik), Klinikum der Universität Heidelberg, Bergheimer Straße 58, 6900, Heidelberg, Germany

    Burkhard Kommerell , Peter Hahn , Wolfgang Kübler , Hubert Mörl  & Ellen Weber , , ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Klose, G., Windler, E., Greten, H. (1982). Befunde zur Pathogenese sekundärer Hyperlipoproteinämien. In: Kommerell, B., Hahn, P., Kübler, W., Mörl, H., Weber, E. (eds) Fortschritte in der Inneren Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68339-8_30

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68339-8_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68340-4

  • Online ISBN: 978-3-642-68339-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation