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Primary and Secondary Pulmonary Hypertension in Childhood: A Clinicopathological Reappraisal

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Pulmonary Diseases

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 73))

Abstract

In adults and older children with pulmonary hypertension the sequence of structural changes occurring in the pulmonary circulation and the relation between structural and haemodynamic change is well recognised, following the classical studies of Heath and Edwards (1958). However, in infants and young children this is not so, and the relation between structural and functional change in the immature lung is different from that seen in adult life. Recently, improved understanding of pulmonary hypertension in childhood has resulted from (a) studies on the normal development of the pulmonary circulation; (b) the application of quantitative morphometric techniques to the study of pulmonary vascular structure, an approach which is essential in a growing organ in health or disease; (c) improved clinical care in the perinatal period, bringing to light the problem of failure of the pulmonary circulation to adapt normally to extra-uterine life when the heart is normal; and (d) improved techniques of angiographic and haemo-dynamic evaluation, which permit a more accurate correlation between pulmonary vascular structural and haemodynamic change in children with congenital heart disease.

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References

  • Anderson EG, Simon G, Reid L (1973) Primary and thrombo-embolic pulmonary hypertension. A quantitative pathological study. J Pathol 110:273–293

    Article  Google Scholar 

  • Arias-Stella J, Recavarren S (1962) Right ventricular hypertrophy in native children living at high altitude. Am J Pathol 41:55–64

    PubMed  CAS  Google Scholar 

  • Arias-Stella J, Saldana M (1962) The muscular pulmonary arteries in people native to high altitude. Med Thorac 19:484–493

    PubMed  CAS  Google Scholar 

  • Aziz KA, Paul MH, Rowe RD (1977) Bronchopulmonary circulation in d-transposition of the great arteries: possible role in genesis of accelerated pulmonary disease. Am J Cardiol 39:432–438

    Article  PubMed  CAS  Google Scholar 

  • Bergofsky EH, Turino GM, Fishman AP (1959) Cardiorespiratory failure in kyphoscoliosis. Medicine (Baltimore) 38:263–317

    CAS  Google Scholar 

  • Berry CL, Greenwald SE (1976) Effects of hypertension on the static mechanical properties and chemical composition of the rat aorta. Cardiovasc Res 10:437–451

    Article  PubMed  CAS  Google Scholar 

  • Berry CL, Greenwald SE, Haworth SG (1981) Mechanical properties of the pulmonary vessels in the normal and in congenital heart disease. In: Godman MJ (ed) Paediatric cardiology 4. Churchill Livingstone, Edinburgh, pp 64–70

    Google Scholar 

  • Berthrong M, Cochran TH (1955) Pathological findings in nine children with “primary” pulmonary hypertension. Bull Johns Hopkins Hosp 97:69–11

    PubMed  CAS  Google Scholar 

  • Boyden EA (1970a) The time lag in the development of bronchial arteries. Anat Rec 166:611–614

    Article  PubMed  CAS  Google Scholar 

  • Boyden EA (1970b) The developing bronchial arteries in a fetus of the twelfth week. Am J Anat 129:357–368

    Article  PubMed  CAS  Google Scholar 

  • Brann L, Halpern W, Mongeon S (1981) Spontaneous contractions and intrinsic tone in small cerebral arteries of the hypertensive rat (Abstr no 613). Fed Proc 40:340

    Google Scholar 

  • Brenner O (1935) Pathology of the vessels of the pulmonary circulation. Part I. Arch Intern Med 56:211–237

    Google Scholar 

  • Brown R, Pickering D (1974) Persistent transitional circulation. Arch Dis Child 49: 883–885

    Article  PubMed  CAS  Google Scholar 

  • Buck RC (1961) Intimai thickening after ligature of arteries. Circ Res 9:418–426

    Google Scholar 

  • Chamberlain D, Hislop A, Hey E, Reid L (1977) Pulmonary hypoplasia in babies with severe rhesus isoimmunisation: a quantitative study. J Pathol 122:43–52

    Article  PubMed  CAS  Google Scholar 

  • Csaba IP, Sulyok E, Ertle T (1978) Relationship of maternal treatment with indo-methacin to persistent fetal circulation syndrome. J Pediatr 92:484

    Article  PubMed  CAS  Google Scholar 

  • Dammann JF Jr, Ferencz C (1956) The significance of the pulmonary vascular bed in congenital heart disease. I. Normal lungs. II. Malformations of the heart in which there is pulmonary stenosis. Am Heart J 52:7–17

    Article  PubMed  Google Scholar 

  • Dammann JF Jr, Baker JP, Muller WH Jr (1959) Pulmonary vascular changes induced by experimentally produced pulmonary arterial hypertension. Surg Gynecol Obstet 105:16–26

    Google Scholar 

  • Dammann JF Jr, McEachen JA, Thompson WM Jr, Smith R, Muller WH (1961) The regression of pulmonary vascular disease after the creation of pulmonary stenosis. J Thorac Cardiovasc Surg 42:722–734

    PubMed  Google Scholar 

  • Davies G, Reid L (1970) Growth of the alveoli and pulmonary arteries in childhood. Thorax 25:669–681

    Article  PubMed  CAS  Google Scholar 

  • Davies G, Reid L (1971) Effect of scoliosis on growth of alveoli and pulmonary arteries and on right ventricle. Arch Dis Child 46:623–632

    Article  PubMed  CAS  Google Scholar 

  • Dawes GS (1968) Foetal and neonatal physiology. Year Book Medical Publishers, Chicago, p 167

    Google Scholar 

  • Delesse MA (1847) Procédé mécanique pour déterminer la composition des roches. C R Acad Sci (Paris) 25:544

    Google Scholar 

  • Dunnill MS (1962) Quantitative methods in the study of pulmonary pathology. Thorax 17:320–328

    Article  Google Scholar 

  • DuShane JW, Weidman WH, Ritter DG (1972) Influence of the natural history of ventricular septal defects on management of patients. Birth Defects 8:63–68

    Google Scholar 

  • Edwards JE (1957) Functional pathology of the pulmonary vascular tree in congenital cardiac disease. Circulation 15:164–196

    PubMed  CAS  Google Scholar 

  • Elliott FM, Reid L (1965) Some new facts about the pulmonary artery and its branching pattern. Clin Radiol 16:193–198

    Article  PubMed  CAS  Google Scholar 

  • Emery JL (1962) Pulmonary embolism in children. Arch Dis Child 37:591–595

    Article  PubMed  CAS  Google Scholar 

  • Emery JL, Hilton HB (1961) Lung and heart complications of the treatment of hydrocephalus by ventriculo-auriculostomy. Surgery 50:309–314

    PubMed  CAS  Google Scholar 

  • Ferencz C (1960) The pulmonary vascular bed in tetralogy of Fallot. II. Changes following a systemic-pulmonary arterial anastomosis. Bull Johns Hopkins Hosp 106: 100–118

    PubMed  CAS  Google Scholar 

  • Ferguson DJ, Varco RL (1955) The relation of blood pressure and flow to the development and regression of experimentally induced pulmonary arteriosclerosis. Circ Res 3:152–158

    PubMed  CAS  Google Scholar 

  • Firor HV (1972) Pulmonary embolization complicating total intravenous alimentation. J Pediatr Surg 7:81

    Article  PubMed  CAS  Google Scholar 

  • Friedli B, Kidd BSL, Mustard WT, Keith JD (1974) Ventricular septal defect within-creased pulmonary vascular resistance. Late results of surgical closure. Am J Cardiol 33:403–409

    Article  PubMed  CAS  Google Scholar 

  • Fulton RM, Hutchinson EC, Jones AM (1952) Ventricular weight in cardiac hypertrophy. Br Heart J 14:413–420

    Article  PubMed  CAS  Google Scholar 

  • Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373–376

    Article  PubMed  CAS  Google Scholar 

  • Gersony WM (1973) Persistence of the fetal circulation. A commentary. J Pediatr 82:1103–1106

    Article  PubMed  CAS  Google Scholar 

  • Gersony WM, Duc GV, Sinclair JC (1969) “PFC” syndrome (persistence of the fetal circulation) (Abstr). Circulation (Suppl III) 40:87

    Google Scholar 

  • Gil J, Weibel ER (1969) Improvements in demonstration of lining layer of lung alveoli by electron microscopy. Respir Physiol 8:13–36

    Article  PubMed  CAS  Google Scholar 

  • Grant MM, Roth N, Brody JS (1981) Basement membrane in fetal rat lungs (Abstr). Fed Proc 40:468

    Google Scholar 

  • Grover RF, Vogel JHK, Averill KH, Blunt SG (1963) Pulmonary hypertension. Individual and species variation relative to vascular reactivity. Am Heart J 66:1–3

    Article  PubMed  CAS  Google Scholar 

  • Guyton JR, Rosenberg RD, Clowes AW, Karovsky MJ (1980) Inhibition of rat arterial smooth muscle cell proliferation by heparin. In vivo studies with anticoagulant and nonanticoagulant heparin. Circ Res 46:625–634

    PubMed  CAS  Google Scholar 

  • Hallidie-Smith KA (1968) The long-term results of closure of ventricular septal defect with pulmonary vascular disease. Am Heart J 76:591–595

    Article  PubMed  CAS  Google Scholar 

  • Harker LC, Kirkpatrick SE, Friedman WF, Bloor CM (1981) Effects of indomethacin on fetal rat lungs; a possible cause of persistent fetal circulation (PFC). Pediatr Res 15:147–151

    Article  PubMed  CAS  Google Scholar 

  • Harrison CV (1958) The pathology of the pulmonary vessels in pulmonary hypertension. Br J Radiol 31:217–226

    Article  PubMed  CAS  Google Scholar 

  • Hawe A, Tsakiris AG, Rastelli GC, Titus JL, McGoon DC (1972) Experimental studies on the pathogenesis of pulmonary vascular obstructive disease. J Thorac Cardiovasc Surg 63:652–669

    PubMed  CAS  Google Scholar 

  • Haworth SG (1979) Pulmonary vascular structure in persistent fetal circulation. In: Godman MJ, Marquis RM (eds) Heart disease in the newborn. Churchill Livingstone, Edinburgh (Paediatric cardiology, vol 2, pp 67–78)

    Google Scholar 

  • Haworth SG, Hislop A (1981) Adaptation of the pulmonary circulation to extrauterine life in the pig and its relevance to the human infant. Cardiovasc Res 15: 108–119

    Article  PubMed  CAS  Google Scholar 

  • Haworth SG, Macartney FJ (1980) Growth and development of the pulmonary circulation in pulmonary atresia with ventricular septal defect and major aorto-pulmonary collateral arteries. Br Heart J 44:14–24

    Article  PubMed  CAS  Google Scholar 

  • Haworth SG, Reid L (1976) Persistent fetal circulation: newly recognised structural features. J Pediatr 88:614–620

    Article  PubMed  CAS  Google Scholar 

  • Haworth SG, Reid L (1977a) A quantitative structural study of the pulmonary circulation in the newborn with aortic atresia, stenosis or coarctation. Thorax 32:121–128

    Article  PubMed  CAS  Google Scholar 

  • Haworth SG, Reid L (1977b) Structural study of pulmonary circulation and of heart in total anomalous pulmonary venous return in early infancy. Br Heart J 39:80–92

    Article  PubMed  CAS  Google Scholar 

  • Haworth SG, Reid L (1977c) Quantitative structural study of the pulmonary circulation in the newborn with pulmonary atresia. Thorax 32:129–133

    Article  PubMed  CAS  Google Scholar 

  • Haworth SG, Reid L (1978) A morphometric study of regional variation in lung structure in infants with pulmonary hypertension and congenital cardiac defect: a justification of lung biopsy. Br Heart J 40:825–831

    Article  PubMed  CAS  Google Scholar 

  • Haworth SG, Sauer U, Bühlmeyer K, Reid L (1977) Development of the pulmonary circulation in ventricular septal defect: a quantitative structural study. Am J Cardiol 40:781–788

    Article  PubMed  CAS  Google Scholar 

  • Haworth SG, de Levai M, Macartney FJ (1981) Hypo- and hyperperfusion in the immature lung: pulmonary arterial development following ligation of left pulmonary artery in the newborn pig. J Thorac Cardiovasc Surg 82:281–292

    PubMed  CAS  Google Scholar 

  • Hayward J, Reid L (1952) Observations on the anatomy of the intrasegmental bronchial tree. Thorax 7:89–97

    Article  PubMed  CAS  Google Scholar 

  • Heath D, Best PV (1958) The tunica media of the arteries in pulmonary hypertension. J Pathol Bacteriol 76:165–174

    Article  PubMed  CAS  Google Scholar 

  • Heath D, Edwards JE (1958) The pathology of hypertensive pulmonary vascular disease. A description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects. Circulation 18:533–547

    PubMed  CAS  Google Scholar 

  • Heath D, Smith P (1978) The electron microscopy of “fibrinoid necrosis” in pulmonary arteries. Thorax 33:579–595

    Article  PubMed  CAS  Google Scholar 

  • Heath D, Helmholtz HF, Burchell HB, DuShane JW, Kirklin JW, Edwards JE (1958) Relation between structural changes in the small pulmonary arteries and the immediate reversibility of pulmonary hypertension following closure of ventricular and atrial septal defects. Circulation 18:1167–1174

    PubMed  CAS  Google Scholar 

  • Heath D, DuShane JW, Wood EH, Edwards JE (1959) The structure of the pulmonary trunk at different ages and in cases of pulmonary hypertension and pulmonary stenosis. J Pathol Bacteriol 77:443–456

    Article  PubMed  CAS  Google Scholar 

  • Hislop A, Reid L (1972) Intra-pulmonary arterial development during fetal life -branching pattern and structure. J Anat 113:35–48

    PubMed  CAS  Google Scholar 

  • Hislop A, Reid L (1973) Pulmonary arterial development during childhood — branching pattern and structure. Thorax 28:129–135

    Article  PubMed  CAS  Google Scholar 

  • Hislop A, Reid L (1976a) New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. Br J Exp Pathol 57:542–554

    PubMed  CAS  Google Scholar 

  • Hislop A, Reid L (1976b) Persistent hypoplasia of the lung after repair of congenital diaphragmatic hernia. Thorax 31:450–455

    Article  PubMed  CAS  Google Scholar 

  • Hislop A, Reid L (1977a) Formation of the pulmonary vasculature. In: Hodson WA (ed) Development of the lung. Dekker, New York, p 52

    Google Scholar 

  • Hislop A, Reid L (1977b) Changes in the pulmonary arteries of the rat during recovery from hypoxia-induced pulmonary hypertension. Br J Exp Pathol 58:653–662

    PubMed  CAS  Google Scholar 

  • Hislop A, Hey E, Reid L (1979) The lungs in congenital bilateral renal agenesis and dysplasia. Arch Dis Child 54:32–38

    Article  PubMed  CAS  Google Scholar 

  • Khoury GH, Hawes CR (1963) Primary pulmonary hypertension in children living at. high altitude. J Pediatr 62:177–185

    Article  PubMed  CAS  Google Scholar 

  • Könn G, Storb R (1960) Über den Formwandel der kleinen Lungenarterian des Menschen nach der Geburt. Beitr Pathol Anat 123:212

    Google Scholar 

  • Lauweryns JM, Rosan RC (1970) The unit lobule: A revised concept of the neonatal lung. Proc 2nd European Congress on Perinatal Medicine, London. Perinatal Med 1970:259–263

    Google Scholar 

  • Levin DL, Heymann MA, Kitterman JA, Gregory GA, Phibbs RH, Rudolph AM (1976) Persistent pulmonary hypertension. J Pediatr 89:626–630

    Article  PubMed  CAS  Google Scholar 

  • Levin DL, Fixier DE, Morriss FC, Tyson J (1978) Morphologic analysis of the pulmonary vascular bed in infants exposed in utero to prostaglandin synthetase inhibitors. J Pediatr 92:478–483.

    Article  PubMed  CAS  Google Scholar 

  • Levin DL, Mills LJ, Weinberg AG (1979) Haemodynamic, pulmonary, vascular and myocardial abnormalities secondary to pharmacologic constriction of the fetal ductus arteriosus. Circulation 60:360–364

    PubMed  CAS  Google Scholar 

  • Libi-Sylora M, Greco J, Ferencz C (1968) Postnatal growth of the pulmonary arterial tree. Morphological characteristics. Am J Dis Child 115:191–201

    Google Scholar 

  • Liebow AA, Hales MR, Lindskog GE, Bloomer WE (1947) Plastic demonstrations of pulmonary pathology. J Tech Methods 27:116–129

    Google Scholar 

  • Liebow AA, Hales MR, Bloomer WE, Harrison W, Lindskog GE (1950) Studies on the lung after ligation of the pulmonary artery. II. Anatomical changes. Am J Pathol 26:177–185

    PubMed  CAS  Google Scholar 

  • Ljungquist A (1963) The intrarenal arterial pattern in the normal and diseased human kidney. Acta Med Scand (Suppl) 174:401

    Google Scholar 

  • Manchester D, Margolis HS, Sheldon RE (1975) Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn. Am J Obstet Gynecol 126:467–469

    Google Scholar 

  • Massion WH, Schilling JA (1964) Physiological effects of lung resection in adult and puppy dogs. J Thorac Cardiovasc Surg 48:239–249

    PubMed  CAS  Google Scholar 

  • Meyrick B, Reid L (1978) The effect of continued hypoxia on rat pulmonary arterial ciruclation. Lab Invest 38:188–200

    PubMed  CAS  Google Scholar 

  • Meyrick B, Reid L (1979) Ultrastructural features of the distended pulmonary arteries of the normal rat. Anat Rec 193:71–98

    Article  PubMed  CAS  Google Scholar 

  • Meyrick B, Reid L (1980a) Endothelial and subintimal changes in rat hilar pulmonary artery during recovery from hypoxia. A quantitative structural study. Lab Invest 42:603–615

    PubMed  CAS  Google Scholar 

  • Meyrick B, Reid L (1980b) Hypoxia-induced structural changes in the media and adventitia of the rat hilar pulmonary artery and their regression. Am J Pathol 100:151–169

    PubMed  CAS  Google Scholar 

  • Meyrick B, Reid L (1980c) Ultrastructural findings in lung biopsy material from children with congenital heart defects. Am J Pathol 101:527–542

    PubMed  CAS  Google Scholar 

  • Naeye RL (1961a) Arterial changes during the perinatal period. Arch Pathol 71:121–128

    PubMed  CAS  Google Scholar 

  • Naeye RL (1961b) Hypoxemia and pulmonary hypertension. Arch Pathol 71:447–452

    PubMed  CAS  Google Scholar 

  • Naeye RL (1961c) Kyphoscoliosis and cor pulmonale: a study of the pulmonary vascular bed. Am J Pathol 38:561–574

    PubMed  CAS  Google Scholar 

  • Naeye RL (1961d) Perinatal changes in the pulmonary vascular bed with stenosis and atresia of the pulmonic valve. Am Heart J 61:586–592

    Article  PubMed  CAS  Google Scholar 

  • Naeye RL (1962) Perinatal vascular changes associated with underdevelopment of the left heart. Am J Pathol 41:287–293

    PubMed  CAS  Google Scholar 

  • Naeye RL (1965) Children at high altitude: pulmonary and renal abnormalities. Circ Res 16:33–38

    PubMed  CAS  Google Scholar 

  • Naeye RL, Harcke HT, Blanc WA (1971) Adrenal gland structure and the development of hyaline membrane disease. Pediatrics 47:650–657

    PubMed  CAS  Google Scholar 

  • Newfeld EA, Paul MH, Muster AJ, Idriss FS (1974) Pulmonary vascular disease in complete transposition of the great arteries: a study of 200 patients. Am J Cardiol 34:75–82

    Article  PubMed  CAS  Google Scholar 

  • Noonan JA, Ehmke DA (1963) Complications of ventriculovenous shunts for control of hydrocephalus. N Engl J Med 269:70–77

    Article  PubMed  CAS  Google Scholar 

  • O’Rahilly R, Debson H, King TS (1950) Subclavian origin of bronchial arteries. Anat Rec 108:227–238

    Article  PubMed  Google Scholar 

  • Parker DJ, Karp RB, Kirklin JW, Bedard P (1972) Lung water and alveolar and capillary volumes after intracardiac surgery. Circulation (Suppl I) 45:139–146

    Google Scholar 

  • Rabinovitch M, Haworth SG, Castaneda AR, Nadas AS, Reid LM (1978) Lung biopsy in congenital heart disease: a morphometric approach to pulmonary vascular disease. Circulation 58:1107–1122

    PubMed  CAS  Google Scholar 

  • Rabinovitch M, Castaneda AR, Reid L (1981) Lung biopsy with frozen section as a diagnostic aid in patients with congenital heart defects. Am J Cardiol 47:77–84

    Article  PubMed  CAS  Google Scholar 

  • Recavarren S, Arias-Stella J (1964) Growth and development of the ventricular myocardium from birth to adult life. Br Heart J 26:187–192

    Article  PubMed  CAS  Google Scholar 

  • Reid L (1967) The pathology of emphysema, Appendix B. Lloyd-Luke, London

    Google Scholar 

  • Reid L (1975) Objectivity and quantification in lung disease. Postgrad Med J 51:711–715

    Article  PubMed  CAS  Google Scholar 

  • Rendas A, Lennox S, Reid L (1979) Aorta-pulmonary shunts in growing pigs. J Thorac Cardiovasc Surg 77:109–118

    PubMed  CAS  Google Scholar 

  • Richardson JW, Phillips CE, DeWeese JA, Manning JA, Mahoney EB (1961) Influence of pulmonary vascular maturity on response to subclavian pulmonary arterial anastomosis (Abstr). Circulation 24:1020

    Google Scholar 

  • Robertson B (1968) The intrapulmonary arterial pattern in normal infancy and in transposition of the great arteries. Acta Pediatr Scand (Suppl) 184

    Google Scholar 

  • Rubatelli FF, Chiazza ML, Zanardon V, Cantarott F (1979) Effect on neonate of maternal treatment with indomethacin (Letter). J Pediatr 94:161

    Article  Google Scholar 

  • Rudolph AM, Neuhauser EBD, Golinko RJ, Auld PAM (1961) Effects of penumonectomy on pulmonary circulation in adult and young animals. Circ Res 9:856–861

    PubMed  CAS  Google Scholar 

  • Rudolph AM, Heymann MA, Lewis AB (1977) Physiology and pharmacology of the pulmonary circulation in the fetus and newborn. In: Hodson WA (ed) Development of the lung. Dekker, New York, pp 503–505 (Lung biology in health and disease, vol 6)

    Google Scholar 

  • Ryland D, Reid L (1975) The pulmonary circulation in cystic fibrosis. Thorax 30:285–292

    Article  PubMed  CAS  Google Scholar 

  • Shaw AFB, Ghareeb AA (1938) The pathogenesis of pulmonary schistosomiasis in Egypt with special reference to Ayerza’s disease. J Pathol Bacteriol 46:401–424

    Article  Google Scholar 

  • Siassi B, Goldberg S J, Emmanouilides GC, Higoshino SM, Lewis E (1971) Persistent pulmonary vascular obstruction in newborn infants. J Pediatr 78:610–615

    Article  PubMed  CAS  Google Scholar 

  • Stein AA, Mauro J, Thibodeau L, Alley R (1969) The histogenesis of cardiac myxomas: relation to other proliferative diseases of subendothelial vasoformative reserve cells. In: Sommers SC (ed) Pathology annual, vol 4. Butterworths, London, p 293

    Google Scholar 

  • Subramanian N, Bakthaviziam A, Sukamar IP, Krishnaswami S, Cherian G (1974) Primary pulmonary hypertension. A clinicopathological study of 11 cases. Indian Heart J 26:171–178

    PubMed  Google Scholar 

  • Tandon HD, Kasturi J (1975) Pulmonary vascular changes associated with isolated mitral stenosis in India. Br Heart J 37:26–36

    Article  PubMed  CAS  Google Scholar 

  • Thompson P, McRae C (1970) Familial pulmonary hypertension. Evidence of autosomal dominant inheritance. Br Heart J 32:758–760

    Article  PubMed  CAS  Google Scholar 

  • Utosonomiya T, Yamamoto N, Maeno M, Morioka T, Akagi M (1977) Detection of lung basement membrane degrading substance in plasma during cardiopulmonary bypass. Am J Surg 134:599–603

    Article  Google Scholar 

  • Vogel JHK, McNamara DG, Hallman G, Rosenberg H (1967) Effects of mild chronic hypoxia on the pulmonary circulation in calves with reactive pulmonary hypertension. Circ Res 21:661–669

    PubMed  CAS  Google Scholar 

  • Wagenvoort CA (1960) Vasoconstriction and medial hypertrophy in pulmonary hypertension. Circulation 22:535–546

    PubMed  CAS  Google Scholar 

  • Wagenvoort CA (1970) Morphologic changes in intrapulmonary veins. Hum Pathol 1:205–213

    Article  PubMed  CAS  Google Scholar 

  • Wagenvoort CA (1973) Hypertensive pulmonary vascular disease complicating congenital heart disease: a review. Cardiovasc Clin 5:43–60

    PubMed  CAS  Google Scholar 

  • Wagenvoort CA, Wagenvoort N (1967) Arterial anastomoses, bronchopulmonary arteries and pulmobronchial arteries in perinatal lungs. Lab Invest 16:13–24

    PubMed  CAS  Google Scholar 

  • Wagenvoort CA, Wagenvoort N (1970) Primary pulmonary hypertension: a pathologic study of the lung vessels in 156 clinically diagnosed cases. Circulation 42:1163–1184

    Google Scholar 

  • Wagenvoort CA, Wagenvoort N (1974) Pathology of the Eisenmenger syndrome and primary pulmonary hypertension. Adv Cardiol 11:123–130

    PubMed  CAS  Google Scholar 

  • Wagenvoort CA, Wagenvoort N (1977) Pathology of pulmonary hypertension. Wiley, New York, pp 69

    Google Scholar 

  • Wagenvoort CA, Wagenvoort N (1977) Pathology of pulmonary hypertension. Wiley, New York, 87

    Google Scholar 

  • Wagenvoort CA, Wagenvoort N (1977) Pathology of pulmonary hypertension. Wiley, New York, 121–125

    Google Scholar 

  • Wagenvoort CA, Wagenvoort N (1977) Pathology of pulmonary hypertension. Wiley, New York, 166–171

    Google Scholar 

  • Weibel ER (1959) Die Blutgefäßanastomosen in der menschlichen Lunge. Z Zellforsch 50:653–692

    Article  PubMed  CAS  Google Scholar 

  • Weibel ER (1962) A quantitative approach to the morphologic study of the peripheral pulmonary vasculature. Med Thorac 19:208–214

    PubMed  CAS  Google Scholar 

  • Weibel ER (1970) Morphometric estimation of pulmonary diffusion capacity. Respir Physiol 11:54–75

    Article  PubMed  Google Scholar 

  • World Health Organisation (1961) Chronic cor pulmonale. WHO Tech Rep Ser 213:6

    Google Scholar 

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  1. S. G. Haworth
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  1. Universitätsklinik Bochum, Hunscheidtstraße 1, D-4630, Bochum 1, Germany

    K.-M Müller (Professor Dr., Leiter des Instituts für Pathologie der Berufsgenossenschaftlichen Krankenanstalten “Bergmannsheil”) (Professor Dr., Leiter des Instituts für Pathologie der Berufsgenossenschaftlichen Krankenanstalten “Bergmannsheil”)

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Haworth, S.G. (1983). Primary and Secondary Pulmonary Hypertension in Childhood: A Clinicopathological Reappraisal. In: Müller, KM. (eds) Pulmonary Diseases. Current Topics in Pathology, vol 73. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69134-8_3

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  • DOI: https://doi.org/10.1007/978-3-642-69134-8_3

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