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Calcium and Calmodulin Control of Neurotransmitter Synthesis and Release

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Calcium and Cell Physiology

Abstract

Calcium ions play a major role in the activity and function of nervous tissue (Rubin 1972; Rasmussen and Goodman 1977). One of the most widely recognized roles of Ca2+ in synaptic function is its action in synaptic modulation and neurotransmission. Earlier studies demonstrated that the relase of neurotransmitter substances by vertebrate neuromuscular junctions was dependent on the Ca2+ ion concentration in the media (Rubin 1972; DelCastillo and Stark 1952). Studies at the synaptic level showed that the effects of Ca2+ on neurotransmission were not secondary to effects of Ca2+ on the presynaptic action potential, but were directly dependent on the entry of Ca2+ into the nerve terminal (Katz and Miledi 1969, 1970; Miledi and Slater 1966; Miledi 1973). The role of Ca2+ in stimulus-secretion coupling has also been demonstrated in a variety of tissues (Douglas 1968).

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Authors and Affiliations

  1. Department of Neurology, Yale University School of Medicine, New Haven, CT, 06510, USA

    R. J. DeLorenzo

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  1. R. J. DeLorenzo
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Editors and Affiliations

  1. Gödecke Research Institute, Gödecke AG, Mooswaldallee 1–9, 7800, Freiburg, Germany

    Dieter Marmé

  2. Institute of Biology III, University of Freiburg, Schänzlestr. 1, 7800, Freiburg, Germany

    Dieter Marmé

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© 1985 Springer-Verlag, Berlin Heidelberg

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DeLorenzo, R.J. (1985). Calcium and Calmodulin Control of Neurotransmitter Synthesis and Release. In: Marmé, D. (eds) Calcium and Cell Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70070-5_13

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  • DOI: https://doi.org/10.1007/978-3-642-70070-5_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70072-9

  • Online ISBN: 978-3-642-70070-5

  • eBook Packages: Springer Book Archive

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