Abstract
Differentiation is generally conceived to be a program of gene expression, primarily determined by regulation of transeriptional processes. In some cell types, however, including those constituting the erythron, one can distinguish a subprogram which involves practically exclusively posttranscriptional e vents. This phase of differentiation may be designated as maturation. During the differentiation of the erythron the activity of the nucleus ceases after the stage of the basophilic erythroblast. There ensues pyknosis of the nucleus with cessation of new formation and export of ribonucleic acids. The pyknotic nucleus of the late erythroblast (normoblast) is expelled in the mammalia, but is retained in an inactive form in all other vertebrates. The transition from the basophilic erythroblast to the normoblast defines clearly the end of the transscriptional phase of differentiation and the beginning of its maturational phase.
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Rapoport, S.M. (1985). Mechanisms of the Maturation of the Reticulocyte. In: Gilles, R. (eds) Circulation, Respiration, and Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70610-3_26
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DOI: https://doi.org/10.1007/978-3-642-70610-3_26
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